Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Davidson MH et al. | Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. | 2007 | Clin Ther | pmid:17825687 |
Yang DY et al. | Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. | 2007 | Neurotoxicology | pmid:17854901 |
Wittwer J and Hersberger M | The two faces of the 15-lipoxygenase in atherosclerosis. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17869078 |
Block RC et al. | EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. | 2008 | Atherosclerosis | pmid:17875307 |
Wright SA et al. | A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. | 2008 | Ann. Rheum. Dis. | pmid:17875549 |
Shah AP et al. | Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. | 2007 | J. Cardiovasc. Pharmacol. Ther. | pmid:17875948 |
Aires V et al. | Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. | 2007 | Mol. Pharmacol. | pmid:17878267 |
Huang LS et al. | Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives. | 2007 | Lipids | pmid:17879105 |
Andersson C et al. | Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. | 2008 | J. Cyst. Fibros. | pmid:17889625 |
Pignier C et al. | Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity. | 2007 | Basic Res. Cardiol. | pmid:17891522 |
Takenaka A et al. | Unsaturated phosphatidylethanolamine as effective synergist in combination with alpha-tocopherol. | 2007 | J Oleo Sci | pmid:17898457 |
Barre DE | The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. | 2007 | J Oleo Sci | pmid:17898498 |
Ando Y and Nozaki M | Lipid profile of mysid Neomysis intermedia and its changes by feeding DHA-rich marine lipids. | 2007 | J Oleo Sci | pmid:17898515 |
Buydens-Branchey L and Branchey M | Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers. | 2008 | Psychiatry Res | pmid:17900705 |
Huang WL et al. | A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. | 2007 | Brain | pmid:17901087 |
Polozova A and Salem N | Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers. | 2007 | J. Mol. Neurosci. | pmid:17901547 |
Watkins PA and Hamilton JA | Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids. | 2007 | J. Mol. Neurosci. | pmid:17901549 |
Watkins PA and Hamilton JA | Roundtable discussion of session 4: fatty acids and lipids in brain disorders. | 2007 | J. Mol. Neurosci. | pmid:17901556 |
Colombo C | Liver disease in cystic fibrosis. | 2007 | Curr Opin Pulm Med | pmid:17901760 |
Li CC et al. | DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904175 |
Mollard RC and Weiler HA | Bone resorption varies as a function of time of day and quantity of dietary long chain polyunsaturated fatty acids. | 2008 | J. Nutr. Biochem. | pmid:17904343 |
Chen S and Subbaiah PV | Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues. | 2007 | Biochim. Biophys. Acta | pmid:17905648 |
Yagil C and Yagil Y | Peroxisome proliferator-activated receptor alpha: friend or foe? | 2007 | Hypertension | pmid:17909117 |
Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
Hoffman D et al. | Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. | 2008 | Lipids | pmid:17912568 |
Song WL et al. | Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. | 2008 | J. Biol. Chem. | pmid:17921521 |
Cerchietti LC et al. | Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. | 2007 | Nutr Cancer | pmid:17927497 |
Little SJ et al. | Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17928211 |
Rahman MM et al. | Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. | 2008 | J. Cell. Physiol. | pmid:17929247 |
Blum R et al. | Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17933446 |
Salvati S et al. | Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. | 2008 | J. Neurosci. Res. | pmid:17941053 |
Pazirandeh S et al. | Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. | 2007 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:17947609 |
Chen S and Li KW | Mass spectrometric identification of molecular species of phosphatidylcholine and lysophosphatidylcholine extracted from shark liver. | 2007 | J. Agric. Food Chem. | pmid:17949052 |
Schaefer MB et al. | Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: impact on adhesion and apoptosis. | 2008 | Atherosclerosis | pmid:17950294 |
Sakamoto T et al. | Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. | 2007 | Brain Res. | pmid:17950710 |
Schiavone A et al. | Breast meat traits of Muscovy ducks fed on a microalga (Crypthecodinium cohnii) meal supplemented diet. | 2007 | Br. Poult. Sci. | pmid:17952729 |
Xia Y et al. | [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. | 2007 | Wei Sheng Yan Jiu | pmid:17953212 |
Serhan CN et al. | Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins. | 2007 | Meth. Enzymol. | pmid:17954222 |
Arneson KO and Roberts LJ | Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. | 2007 | Meth. Enzymol. | pmid:17954232 |
von Schacky C | [Omega-3 fatty acids in cardiology. Latest developments]. | 2007 | MMW Fortschr Med | pmid:17955786 |
Rogers PJ et al. | No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. | 2008 | Br. J. Nutr. | pmid:17956647 |
Dunstan JA et al. | The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. | 2007 | Pediatr. Res. | pmid:17957152 |
Muthayya S et al. | The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. | 2009 | Eur J Clin Nutr | pmid:17957193 |
Bazan NG | Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17962433 |
Chucair AJ et al. | Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17962470 |
Serhan CN and Chiang N | Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. | 2008 | Br. J. Pharmacol. | pmid:17965751 |
Sugihara S et al. | An EntD-like phosphopantetheinyl transferase gene from Photobacterium profundum SS9 complements pfa genes of Moritella marina strain MP-1 involved in biosynthesis of docosahexaenoic acid. | 2008 | Biotechnol. Lett. | pmid:17973084 |
Blum R et al. | One-generation reproductive toxicity study of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17976878 |
Milte CM et al. | Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. | 2008 | Br. J. Nutr. | pmid:17977469 |
Delarue J et al. | Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients. | 2008 | Br. J. Nutr. | pmid:17977474 |
Haworth O and Levy BD | Endogenous lipid mediators in the resolution of airway inflammation. | 2007 | Eur. Respir. J. | pmid:17978156 |
Gajewski BJ et al. | Predicting accrual in clinical trials with Bayesian posterior predictive distributions. | 2008 | Stat Med | pmid:17979152 |
Krauss-Etschmann S et al. | Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. | 2008 | J. Allergy Clin. Immunol. | pmid:17980419 |
Wu KT et al. | Vasodilator action of docosahexaenoic acid (DHA) in human coronary arteries in vitro. | 2007 | Chin J Physiol | pmid:17982914 |
Stark KD | The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. | 2008 | Lipids | pmid:17985169 |
Sublette ME et al. | Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. | 2007 | Bipolar Disord | pmid:17988367 |
Carnielli VP et al. | Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids. | 2007 | Am. J. Clin. Nutr. | pmid:17991642 |
Conklin SM et al. | High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | 2007 | Psychosom Med | pmid:17991818 |
Siahanidou T et al. | Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA). | 2007 | Am J Perinatol | pmid:17992715 |
Zanoni G et al. | Asymmetric synthesis of 14-A4t-neuroprostane: hunting for a suitable biomarker for neurodegenerative diseases. | 2007 | J. Org. Chem. | pmid:17994761 |
Moriya H et al. | Combination effect of herring roe lipids and proteins on plasma lipids and abdominal fat weight of mouse. | 2007 | J. Food Sci. | pmid:17995707 |
Borneo R et al. | Stability and consumer acceptance of long-chain omega-3 fatty acids (eicosapentaenoic acid, 20:5, n-3 and docosahexaenoic acid, 22:6, n-3) in cream-filled sandwich cookies. | 2007 | J. Food Sci. | pmid:17995897 |
Kale A et al. | Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. | 2008 | Schizophr. Res. | pmid:17997280 |
Rühl R et al. | Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. | 2008 | Br. J. Nutr. | pmid:18005485 |
Kuriki K et al. | Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. | 2007 | Cancer Epidemiol. Biomarkers Prev. | pmid:18006930 |
Poulsen RC et al. | Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. | 2007 | Calcif. Tissue Int. | pmid:18008020 |
De Smedt-Peyrusse V et al. | Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. | 2008 | J. Neurochem. | pmid:18021297 |
Brenna JT and Diau GY | The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18023566 |
Mitchell TW et al. | Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics. | 2007 | Exp. Gerontol. | pmid:18029129 |
Walkowiak J et al. | Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:18030219 |
Calder PC | Immunomodulation by omega-3 fatty acids. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18032006 |
Bhale SD et al. | Oregano and rosemary extracts inhibit oxidation of long-chain n-3 fatty acids in menhaden oil. | 2007 | J. Food Sci. | pmid:18034711 |
Taha AY et al. | Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. | 2008 | J. Neurochem. | pmid:18036191 |
Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
Calderon F and Kim HY | Role of RXR in neurite outgrowth induced by docosahexaenoic acid. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036800 |
Michael-Titus AT | Omega-3 fatty acids and neurological injury. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036801 |
Plourde M et al. | Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036804 |
Calon F and Cole G | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18037281 |
Pomponi M and Pomponi M | DHA deficiency and Alzheimer's disease. | 2008 | Clin Nutr | pmid:18037538 |
Pifferi F et al. | n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18042368 |
Palmblad J et al. | [Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited]. | 2007 Oct 31-Nov 6 | Lakartidningen | pmid:18050989 |
Armah CK et al. | Fish oil fatty acids improve postprandial vascular reactivity in healthy men. | 2008 | Clin. Sci. | pmid:18052925 |
Das UN | Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18054217 |
Tamai T et al. | Effects of supplemented diacylglycerol rich in docosahexaenoic acid on serum triacylglycerol in a diet-induced hyperlipidemic model of rats are essentially equivalent to those of triacylglycerol rich in docosahexaenoic acid. | 2007 | Biol. Pharm. Bull. | pmid:18057730 |
Zhang W et al. | Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells. | 2007 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:18060632 |
Buydens-Branchey L et al. | Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. | 2008 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:18060675 |
Rapoport SI et al. | Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060754 |
Mukherjee PK et al. | Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060755 |
Maes M et al. | Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. | 2007 | Neuro Endocrinol. Lett. | pmid:18063921 |
Harris WS et al. | Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. | 2007 | Am. J. Clin. Nutr. | pmid:18065578 |
Muskiet FA et al. | The basis of recommendations for docosahexaenoic and arachidonic acids in infant formula: absolute or relative standards? | 2007 | Am. J. Clin. Nutr. | pmid:18065601 |
Okuyama H et al. | Significance of antioxidative functions of eicosapentaenoic and docosahexaenoic acids in marine microorganisms. | 2008 | Appl. Environ. Microbiol. | pmid:18065628 |
Lyberg AM and Adlercreutz P | Lipase specificity towards eicosapentaenoic acid and docosahexaenoic acid depends on substrate structure. | 2008 | Biochim. Biophys. Acta | pmid:18067872 |
Chapkin RS et al. | Docosahexaenoic acid alters the size and distribution of cell surface microdomains. | 2008 | Biochim. Biophys. Acta | pmid:18068112 |
Yuen AW et al. | Erythrocyte and plasma fatty acid profiles in patients with epilepsy: does carbamazepine affect omega-3 fatty acid concentrations? | 2008 | Epilepsy Behav | pmid:18068523 |
Kidd PM | Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. | 2007 | Altern Med Rev | pmid:18072818 |
Yi L et al. | [Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]. | 2007 | Ai Zheng | pmid:18076787 |
Nah SY et al. | Ginsenosides: are any of them candidates for drugs acting on the central nervous system? | 2007 | CNS Drug Rev | pmid:18078425 |
Hirunpanich V et al. | Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats. | 2008 | Int J Pharm | pmid:18082981 |
Peltier S et al. | Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083359 |