DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mairesse G et al. | Effects of geographic source, rearing system, and season on the nutritional quality of wild and farmed Perca fluviatilis. | 2006 | Lipids | pmid:16711596 |
| Ishihara K et al. | Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. | 1998 | Lipids | pmid:9870906 |
| Hansen JB et al. | Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. | 1998 | Lipids | pmid:9870908 |
| Vaagenes H et al. | Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. | 1998 | Lipids | pmid:9870909 |
| Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
| Garrido A et al. | Ingestion of high doses of fish oil increases the susceptibility of cellular membranes to the induction of oxidative stress. | 1989 | Lipids | pmid:2555651 |
| Hamazaki T et al. | Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. | 1999 | Lipids | pmid:10419086 |
| Crawford MA et al. | Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. | 1999 | Lipids | pmid:10419087 |
| Conquer JA et al. | Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. | 2000 | Lipids | pmid:10757545 |
| Gaposchkin DP et al. | Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. | 2000 | Lipids | pmid:10757549 |
| Kim HY and Hamilton J | Accumulation of docosahexaenoic acid in phosphatidylserine is selectively inhibited by chronic ethanol exposure in C-6 glioma cells. | 2000 | Lipids | pmid:10757550 |
| Weete JD et al. | Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. | 1997 | Lipids | pmid:9270975 |
| Klingler M et al. | Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. | 2011 | Lipids | pmid:21681560 |
| Ando Y and Oomi Y | Positional distribution of highly unsaturated fatty acids in triacyl-sn-glycerols of Artemia nauplii enriched with docosahexaenoic acid ethyl ester. | 2001 | Lipids | pmid:11521972 |
| Crawford MA et al. | The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants. | 2003 | Lipids | pmid:12848275 |
| Tanaka T et al. | Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. | 2012 | Lipids | pmid:22411689 |
| Ryan AS et al. | The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet. | 2009 | Lipids | pmid:19655188 |
| McLaren JE et al. | Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. | 2011 | Lipids | pmid:21822944 |
| Kimura F et al. | Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. | 2011 | Lipids | pmid:21901511 |
| Ikemoto A et al. | Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. | 2000 | Lipids | pmid:11104017 |
| Trofimiuk E and Braszko JJ | Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. | 2011 | Lipids | pmid:21442272 |
| Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
| Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
| Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
| Green P and Yavin E | Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. | 1996 | Lipids | pmid:8729125 |
| Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
| Sankaran D et al. | Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat. | 2004 | Lipids | pmid:15233398 |
| Meyer BJ et al. | Improvement of major depression is associated with increased erythrocyte DHA. | 2013 | Lipids | pmid:23733443 |
| Hansen JB et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. | 1998 | Lipids | pmid:9507234 |
| Howe PR et al. | Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. | 2002 | Lipids | pmid:12558057 |
| Peterson LD et al. | Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. | 1998 | Lipids | pmid:9507239 |
| Besson N et al. | Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages. | 2006 | Lipids | pmid:17707985 |
| Stillwell W et al. | Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. | 1997 | Lipids | pmid:9168456 |
| Bell JG et al. | The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. | 1997 | Lipids | pmid:9168458 |
| Kelley DS et al. | Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. | 1999 | Lipids | pmid:10443964 |
| Hoffman DR et al. | Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. | 1999 | Lipids | pmid:10443966 |
| Liu M et al. | Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. | 2014 | Lipids | pmid:24254970 |
| Lyberg AM and Adlercreutz P | Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. | 2006 | Lipids | pmid:16555474 |
| Li D et al. | A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. | 2006 | Lipids | pmid:16555476 |
| Ackman RG | Docosahexaenoic acid in the infant and its mother. | 1999 | Lipids | pmid:10102238 |
| Innis SM et al. | Neonatal polyunsaturated fatty acid metabolism. | 1999 | Lipids | pmid:10102240 |
| Carlson SE and Neuringer M | Polyunsaturated fatty acid status and neurodevelopment: a summary and critical analysis of the literature. | 1999 | Lipids | pmid:10102243 |
| Otsuka R et al. | Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. | 2013 | Lipids | pmid:23389403 |
| Bouziane M et al. | Dietary protein deficiency affects n-3 and n-6 polyunsaturated fatty acids hepatic storage and very low density lipoprotein transport in rats on different diets. | 1994 | Lipids | pmid:8177019 |
| Harel M et al. | Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. | 2000 | Lipids | pmid:11132186 |
| Uhl O et al. | Changes of molecular glycerophospholipid species in plasma and red blood cells during docosahexaenoic acid supplementation. | 2013 | Lipids | pmid:24043586 |
| Shomonov-Wagner L et al. | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. | 2015 | Lipids Health Dis | pmid:25889505 |
| Corsetto PA et al. | Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. | 2011 | Lipids Health Dis | pmid:21569413 |
| Berger A et al. | How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome. | 2006 | Lipids Health Dis | pmid:16623957 |
| Wood PL et al. | Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease. | 2011 | Lipids Health Dis | pmid:22142382 |
| Casey JM et al. | Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. | 2013 | Lipids Health Dis | pmid:24139088 |
| Bravo E et al. | Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis. | 2010 | Lipids Health Dis | pmid:21059219 |
| Yang ZH et al. | Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. | 2012 | Lipids Health Dis | pmid:22846384 |
| Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
| Metherel AH et al. | Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. | 2013 | Lipids Health Dis | pmid:23425563 |
| Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Terre'Blanche G et al. | Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid--a case report. | 2011 | Lipids Health Dis | pmid:21871076 |
| Ercan S et al. | Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. | 2015 | Lipids Health Dis | pmid:25889219 |
| Faragó N et al. | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. | 2011 | Lipids Health Dis | pmid:21961478 |
| Huang HL et al. | Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. | 2013 | Lipids Health Dis | pmid:23496882 |
| Fahrmann JF and Hardman WE | Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. | 2013 | Lipids Health Dis | pmid:23497075 |
| Schuchardt JP et al. | Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. | 2011 | Lipids Health Dis | pmid:21854650 |
| Stark KD et al. | Docosahexaenoic acid and n-6 docosapentaenoic acid supplementation alter rat skeletal muscle fatty acid composition. | 2007 | Lipids Health Dis | pmid:17459159 |
| Yoshida S et al. | Metabolism of fatty acids and lipid hydroperoxides in human body monitoring with Fourier transform Infrared Spectroscopy. | 2009 | Lipids Health Dis | pmid:19627618 |
| Kawabata T et al. | Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. | 2011 | Lipids Health Dis | pmid:21838914 |
| Kong W et al. | Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family. | 2010 | Lipids Health Dis | pmid:20122166 |
| Aslan M et al. | A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy. | 2014 | Lipids Health Dis | pmid:24694037 |
| Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
| Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
| Berge RK et al. | Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. | 2015 | Lipids Health Dis | pmid:26666303 |
| Linhartova P and Sampels S | Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. | 2015 | Lipids Health Dis | pmid:26627047 |
| Prostek A et al. | The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. | 2014 | Lipids Health Dis | pmid:24387137 |
| Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
| Mobraten K et al. | Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. | 2013 | Lipids Health Dis | pmid:23849180 |
| Aslan M et al. | LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. | 2013 | Lipids Health Dis | pmid:24195588 |
| Tateishi N et al. | Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. | 2014 | Lipids Health Dis | pmid:24507383 |
| Bloomer RJ et al. | Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. | 2009 | Lipids Health Dis | pmid:19691834 |
| Kagan ML et al. | Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. | 2013 | Lipids Health Dis | pmid:23855409 |
| Taltavull N et al. | Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome. | 2014 | Lipids Health Dis | pmid:24512213 |
| Wang RX et al. | Docosahexaenoic acid has influence on action potentials and transient outward potassium currents of ventricular myocytes. | 2010 | Lipids Health Dis | pmid:20398403 |
| Ramprasath VR et al. | Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. | 2013 | Lipids Health Dis | pmid:24304605 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| LluÃs L et al. | Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. | 2013 | Lipids Health Dis | pmid:24083393 |
| Tang X et al. | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. | 2012 | Lipids Health Dis | pmid:22676394 |
| Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |
| Souza CO et al. | Milk protein-based formulas containing different oils affect fatty acids balance in term infants: A randomized blinded crossover clinical trial. | 2017 | Lipids Health Dis | pmid:28410612 |
| Quartu M et al. | Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. | 2017 | Lipids Health Dis | pmid:28103941 |
| Martinez M et al. | The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome. | 2010 | Lipids Health Dis | pmid:20828389 |
| Haugaard SB et al. | Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention. | 2009 | Lipids Health Dis | pmid:19678948 |
| Rossi E and Costa M | Fish oil derivatives as a prophylaxis of recurrent miscarriage associated with antiphospholipid antibodies (APL): a pilot study. | 1993 | Lupus | pmid:8305926 |
| Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
| Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
| Goda AA et al. | Astaxanthin and Docosahexaenoic Acid Reverse the Toxicity of the Maxi-K (BK) Channel Antagonist Mycotoxin Penitrem A. | 2016 | Mar Drugs | pmid:27834847 |
| Martins DA et al. | Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. | 2013 | Mar Drugs | pmid:23807546 |
| Nanjappa D et al. | Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. | 2014 | Mar Drugs | pmid:24445306 |
| Mühlroth A et al. | Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. | 2013 | Mar Drugs | pmid:24284429 |
| Russell FD and Bürgin-Maunder CS | Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. | 2012 | Mar Drugs | pmid:23203276 |
| Jiang M et al. | Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. | 2014 | Mar Drugs | pmid:24608969 |
| Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |