Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Parker G et al. | Omega-3 fatty acids and mood disorders. | 2006 | Am J Psychiatry | pmid:16741195 |
Gladyshev MI et al. | [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. | 2006 | Vopr Pitan | pmid:16739608 |
Friedman AN et al. | Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. | 2006 | Am. J. Kidney Dis. | pmid:16731302 |
Li D et al. | Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16716580 |
Mairesse G et al. | Effects of geographic source, rearing system, and season on the nutritional quality of wild and farmed Perca fluviatilis. | 2006 | Lipids | pmid:16711596 |
Mantovani G et al. | A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. | 2006 | Cancer Epidemiol. Biomarkers Prev. | pmid:16702388 |
Coti Bertrand P et al. | Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. | 2006 | J. Nutr. | pmid:16702323 |
Mjøs SA | Prediction of equivalent chain lengths from two-dimensional fatty acid retention indices. | 2006 | J Chromatogr A | pmid:16701676 |
Kishida E et al. | Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor. | 2006 | Biochim. Biophys. Acta | pmid:16698313 |
Camuesco D et al. | Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. | 2006 | Clin Nutr | pmid:16698151 |
Gorjão R et al. | Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. | 2006 | Clin Nutr | pmid:16697494 |
Turner N et al. | Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. | 2006 May-Jun | Physiol. Biochem. Zool. | pmid:16691518 |
Igarashi M et al. | Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. | 2006 | J. Lipid Res. | pmid:16687661 |
Waterhouse KE et al. | Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. | 2006 | Reproduction | pmid:16672353 |
Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
Coetzee M et al. | Effects of arachidonic acid, docosahexaenoic acid, prostaglandin E(2) and parathyroid hormone on osteoprotegerin and RANKL secretion by MC3T3-E1 osteoblast-like cells. | 2007 | J. Nutr. Biochem. | pmid:16650751 |
Narayanan NK et al. | Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells. | 2006 | Int. J. Cancer | pmid:16646082 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
King VR et al. | Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. | 2006 | J. Neurosci. | pmid:16641248 |
Hirunpanich V and Sato H | Docosahexaenoic acid (DHA) inhibits saquinavir metabolism in-vitro and enhances its bioavailability in rats. | 2006 | J. Pharm. Pharmacol. | pmid:16640834 |
Wright K et al. | Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research. | 2006 | J Spec Pediatr Nurs | pmid:16635189 |
Wurtman RJ et al. | Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. | 2006 | Brain Res. | pmid:16631143 |
Burja AM et al. | Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16625394 |
Berger A et al. | How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome. | 2006 | Lipids Health Dis | pmid:16623957 |
Catalá A | An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16621670 |
Xue H et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. | 2006 | Vascul. Pharmacol. | pmid:16616699 |
O'Keefe JH et al. | Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. | 2006 | Am. J. Cardiol. | pmid:16616012 |
Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
Aldámiz-EchevarrÃa L et al. | Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. | 2006 | J. Inherit. Metab. Dis. | pmid:16601869 |
Kawai Y et al. | Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification. | 2006 | J. Lipid Res. | pmid:16582421 |
Bazan NG | Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. | 2006 | Trends Neurosci. | pmid:16580739 |
Knudsen VK et al. | Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. | 2006 | BJOG | pmid:16579802 |
Geppert J et al. | Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial. | 2006 | Br. J. Nutr. | pmid:16571158 |
German OL et al. | Ceramide is a mediator of apoptosis in retina photoreceptors. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16565407 |
Wang Y et al. | Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16563756 |
Unagul P et al. | Coconut water as a medium additive for the production of docosahexaenoic acid (C22:6 n3) by Schizochytrium mangrovei Sk-02. | 2007 | Bioresour. Technol. | pmid:16563749 |
Bhattacharya A et al. | Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice. | 2007 | J. Nutr. Biochem. | pmid:16563716 |
Strokin M et al. | Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2. | 2006 | Neuroscience | pmid:16563639 |
Li D et al. | A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. | 2006 | Lipids | pmid:16555476 |
Lyberg AM and Adlercreutz P | Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. | 2006 | Lipids | pmid:16555474 |
Wang WP et al. | Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. | 2006 | Brain Res. | pmid:16546145 |
Fer M et al. | Determination of polyunsaturated fatty acid monoepoxides by high performance liquid chromatography-mass spectrometry. | 2006 | J Chromatogr A | pmid:16545829 |
Li Q et al. | Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. | 2006 | Sci. China, C, Life Sci. | pmid:16544577 |
Straarup EM et al. | The stereospecific triacylglycerol structures and Fatty Acid profiles of human milk and infant formulas. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540799 |
Hoffman DR et al. | Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540798 |
Pall H et al. | Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540796 |
Tian Q et al. | Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. | 2006 | Chem. Biol. Interact. | pmid:16540100 |
Cerolini S et al. | Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. | 2006 | Theriogenology | pmid:16530814 |
Kawakita E et al. | Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. | 2006 | Neuroscience | pmid:16527422 |
Shi Y and Pestka JJ | Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression. | 2006 | J. Nutr. Biochem. | pmid:16524712 |
Qiu C et al. | Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. | 2006 | Arch. Gynecol. Obstet. | pmid:16520922 |
Usami M et al. | Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. | 2006 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:16517957 |
Shoji H et al. | Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. | 2006 | Free Radic. Res. | pmid:16517502 |
Li CC et al. | n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. | 2006 | J. Nutr. Biochem. | pmid:16517146 |
Scambi C et al. | Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients? | 2006 | J. Cyst. Fibros. | pmid:16516563 |
Abedin M et al. | N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. | 2006 | Circ. Res. | pmid:16514067 |
Sanders TA et al. | Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women. | 2006 | Br. J. Nutr. | pmid:16512939 |
Chiu LC et al. | Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. | 2005 | Biomed. Pharmacother. | pmid:16507396 |
Jumpsen JA et al. | Fatty acids in blood and intestine following docosahexaenoic acid supplementation in adults with cystic fibrosis. | 2006 | J. Cyst. Fibros. | pmid:16507353 |
Heinemann KM and Bauer JE | Docosahexaenoic acid and neurologic development in animals. | 2006 | J. Am. Vet. Med. Assoc. | pmid:16506930 |
Ko WC et al. | Efficient hydrolysis of tuna oil by a surfactant-coated lipase in a two-phase system. | 2006 | J. Agric. Food Chem. | pmid:16506843 |
Chattipakorn N et al. | Effects of n-3 polyunsaturated fatty acid on upper limit of vulnerability shocks. | 2006 | Int. J. Cardiol. | pmid:16503251 |
da Silva TL et al. | Effect of n-dodecane on Crypthecodinium cohnii fermentations and DHA production. | 2006 | J. Ind. Microbiol. Biotechnol. | pmid:16501933 |
Parker GB et al. | Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. | 2006 | Psychiatry Res | pmid:16499974 |
Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
Levant B et al. | Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. | 2006 | Biol. Psychiatry | pmid:16499882 |
López-Alarcón M et al. | [The effect of docosahexaenoic acid on the loss of appetite in pediatric patients with pneumonia]. | 2006 Jan-Feb | Rev Med Inst Mex Seguro Soc | pmid:16497254 |
Perveen Z et al. | Isolation and characterization of a novel thraustochytrid-like microorganism that efficiently produces docosahexaenoic acid. | 2006 | Biotechnol. Lett. | pmid:16489498 |
Arachchige PG et al. | Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. | 2006 | Metab. Clin. Exp. | pmid:16483883 |
Bauch A et al. | Dietary intake and sources of long-chain n-3 PUFAs in German adults. | 2006 | Eur J Clin Nutr | pmid:16482078 |
Goyens PL and Mensink RP | Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. | 2006 | Eur J Clin Nutr | pmid:16482073 |
Mamalakis G et al. | Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. | 2006 | Eur J Clin Nutr | pmid:16482070 |
Park YS et al. | Prolyl endopeptidase inhibitory activity of unsaturated fatty acids. | 2006 | J. Agric. Food Chem. | pmid:16478242 |
Hossain Z et al. | Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells. | 2006 | Mol. Cell. Biochem. | pmid:16477371 |
Mori TA and Woodman RJ | The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. | 2006 | Curr Opin Clin Nutr Metab Care | pmid:16477172 |
Hubbard AF et al. | Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation. | 2006 | Arch. Ophthalmol. | pmid:16476896 |
Pfrommer CA et al. | Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16473961 |
Sekine S et al. | Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats. | 2006 | Nutrition | pmid:16472975 |
Seo J et al. | Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins. | 2006 | FASEB J. | pmid:16469846 |
Delarue J et al. | Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. | 2006 | Br. J. Nutr. | pmid:16469141 |
Glomset JA | Role of docosahexaenoic acid in neuronal plasma membranes. | 2006 | Sci. STKE | pmid:16467193 |
Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
Mamalakis G et al. | Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. | 2006 | Eur J Clin Nutr | pmid:16465199 |
Poulos A et al. | Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester. | 1991 | Immunology | pmid:1646160 |
Perez MA et al. | Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. | 2006 | J. Nutr. Biochem. | pmid:16457997 |
Julien C et al. | Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. | 2006 | Neurochem. Int. | pmid:16442670 |
Williams CM and Burdge G | Long-chain n-3 PUFA: plant v. marine sources. | 2006 | Proc Nutr Soc | pmid:16441943 |
Tapia-Salazar M et al. | Effect of DHA supplementation on digestible starch utilization by rainbow trout. | 2006 | Br. J. Nutr. | pmid:16441919 |
Arab K et al. | Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. | 2006 | Br. J. Nutr. | pmid:16441913 |
Mayes C et al. | Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | 2006 | Pediatr. Res. | pmid:16439591 |
Burdge GC et al. | Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. | 2006 Jan-Feb | Reprod. Nutr. Dev. | pmid:16438916 |
Samadi P et al. | Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys. | 2006 | Ann. Neurol. | pmid:16437566 |
Haugaard SB et al. | Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity. | 2006 | Clin. Endocrinol. (Oxf) | pmid:16430716 |
Christensen JH et al. | Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. | 2006 | BJU Int. | pmid:16430627 |
Hashimoto M et al. | Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. | 2005 | Biochim. Biophys. Acta | pmid:16427803 |
Tsuzuki T et al. | Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. | 2006 | J. Nutr. Biochem. | pmid:16426831 |
Serhan CN et al. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. | 2006 | J. Immunol. | pmid:16424216 |
Jia Q et al. | Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages. | 2006 | J. Nutr. | pmid:16424113 |
Alexander JW et al. | Can immunonutrients reduce rejection rates in African Americans? | 2005 | Exp Clin Transplant | pmid:16417441 |
Ren H et al. | Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16410047 |