DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qu L et al. | Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. | 2011 | Lett. Appl. Microbiol. | pmid:21070268 |
| Kim HW et al. | Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. | 2011 | Biochim. Biophys. Acta | pmid:21070866 |
| Sidhu VK et al. | Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling. | 2011 | J. Proteome Res. | pmid:22003853 |
| Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
| Granot E et al. | DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. | 2011 | Mediators Inflamm. | pmid:21941411 |
| Johnson B | Consciousness reinstated using the certainty principle--a better mental health strategy. | 2011 | Nutr Health | pmid:22141192 |
| Westphal C et al. | CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21945326 |
| Wood PL et al. | Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease. | 2011 | Lipids Health Dis | pmid:22142382 |
| Decsi T et al. | Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in pregnant women and their newborns: data from three European countries. | 2011 | Ann. Nutr. Metab. | pmid:22142767 |
| Kohlboeck G et al. | Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. | 2011 | Am. J. Clin. Nutr. | pmid:22071708 |
| Park CK et al. | Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. | 2011 | J. Neurosci. | pmid:22016541 |
| James S et al. | Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). | 2011 | Cochrane Database Syst Rev | pmid:22071839 |
| Chang WK et al. | The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake. | 2011 | Int J Nanomedicine | pmid:22072876 |
| Hull MA | Omega-3 polyunsaturated fatty acids. | 2011 | Best Pract Res Clin Gastroenterol | pmid:22122770 |
| Morin C et al. | Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21057106 |
| Zeng Y et al. | Development of a temperature shift strategy for efficient docosahexaenoic acid production by a marine fungoid protist, Schizochytrium sp. HX-308. | 2011 | Appl. Biochem. Biotechnol. | pmid:21120635 |
| Itakura H et al. | Relationships between plasma fatty acid composition and coronary artery disease. | 2011 | J. Atheroscler. Thromb. | pmid:21099130 |
| Haraguchi T et al. | Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21737922 |
| Johnsen GM et al. | Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. | 2011 | Placenta | pmid:21741084 |
| Keithly JI et al. | Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexaenoic acid. | 2011 | J. Anim. Sci. | pmid:21742943 |
| Sun H et al. | Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. | 2011 | Carcinogenesis | pmid:21771724 |
| Caputo M et al. | Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. | 2011 | J. Cell. Physiol. | pmid:20648548 |
| Opreanu M et al. | The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. | 2011 | Diabetes | pmid:21771974 |
| Kalupahana NS et al. | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. | 2011 | Adv Nutr | pmid:22332072 |
| Wiese DM et al. | The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. | 2011 | Nutr Clin Pract | pmid:21775642 |
| Davis-Bruno K and Tassinari MS | Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. | 2011 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:21678548 |
| Klingler M et al. | Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. | 2011 | Lipids | pmid:21681560 |
| Friedrichs W et al. | Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. | 2011 | Nutr Cancer | pmid:21667400 |
| Sakayori N et al. | Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. | 2011 | Genes Cells | pmid:21668588 |
| Shulse CN and Allen EE | Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. | 2011 | PLoS ONE | pmid:21629834 |
| Okpala I et al. | Pilot study of omega-3 fatty acid supplements in sickle cell disease. | 2011 | APMIS | pmid:21635551 |
| Cook DJ and Heyland DK | Pharmaconutrition in acute lung injury. | 2011 | JAMA | pmid:21976612 |
| Rice TW et al. | Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. | 2011 | JAMA | pmid:21976613 |
| Faragó N et al. | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. | 2011 | Lipids Health Dis | pmid:21961478 |
| Lalancette-Hébert M et al. | Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. | 2011 | Stroke | pmid:21852616 |
| Schuchardt JP et al. | Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. | 2011 | Lipids Health Dis | pmid:21854650 |
| Beck G et al. | Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. | 2011 | J. Neurosci. | pmid:21813701 |
| Konrad M et al. | The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. | 2011 | Int J Sport Nutr Exerc Metab | pmid:21813917 |
| Morin C et al. | 19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca²⺠sensitivity in human pulmonary arteries. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21821782 |
| McLaren JE et al. | Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. | 2011 | Lipids | pmid:21822944 |
| Kawabata T et al. | Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. | 2011 | Lipids Health Dis | pmid:21838914 |
| Tian H et al. | Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. | 2011 | Am. J. Pathol. | pmid:21839062 |
| Trofimiuk E and Braszko JJ | Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. | 2011 | Lipids | pmid:21442272 |
| Chauveau F et al. | Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. | 2011 | Curr Neurovasc Res | pmid:21443458 |
| Collins CT et al. | Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. | 2011 | Br. J. Nutr. | pmid:21443815 |
| Sala-Vila A et al. | Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. | 2011 | Br. J. Nutr. | pmid:21450116 |
| Vincentini O et al. | Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. | 2011 | Clin Nutr | pmid:21421277 |
| Weylandt KH et al. | Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. | 2011 | Carcinogenesis | pmid:21421544 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Stapleton RD et al. | A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. | 2011 | Crit. Care Med. | pmid:21423000 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Kulkarni A et al. | Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. | 2011 | PLoS ONE | pmid:21423696 |
| Bhatia HS et al. | Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. | 2011 | PLoS ONE | pmid:22163304 |
| Park CK et al. | Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. | 2011 | J. Neurosci. | pmid:22171045 |
| Newens KJ et al. | DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity. | 2011 | Am. J. Clin. Nutr. | pmid:21831993 |
| von Schacky C | The Omega-3 Index as a risk factor for cardiovascular diseases. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21726658 |
| Altenburg JD et al. | A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. | 2011 | BMC Cancer | pmid:21510869 |
| Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
| Hadders-Algra M | Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. | 2011 | Am. J. Clin. Nutr. | pmid:21525202 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Escolano-Margarit MV et al. | Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. | 2011 | J. Nutr. | pmid:21525247 |
| Rockett BD et al. | Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. | 2011 | J. Nutr. | pmid:21525263 |
| De Franceschi G et al. | Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. | 2011 | J. Biol. Chem. | pmid:21527634 |
| Schnebelen C et al. | Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. | 2011 | Nutr Res | pmid:21530802 |
| Hanada H et al. | Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs. | 2011 | Cell Biol. Int. | pmid:20812919 |
| Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
| Nudda A et al. | Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. | 2011 | J. Food Sci. | pmid:21535766 |
| Sun C et al. | DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. | 2011 | Mol. Biol. Rep. | pmid:20383747 |
| Wojcicki JM and Heyman MB | Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:20925595 |
| Kim SH et al. | Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. | 2011 | Eur J Clin Nutr | pmid:20877395 |
| Neubronner J et al. | Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters. | 2011 | Eur J Clin Nutr | pmid:21063431 |
| Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
| Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
| Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
| Poudel-Tandukar K et al. | Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. | 2011 | J Affect Disord | pmid:20692041 |
| Mariee AD and Abd-Ellah MF | Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. | 2011 | Ren Fail | pmid:21219208 |
| Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
| Safarinejad MR | Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. | 2011 | Andrologia | pmid:21219381 |
| Cotogni P et al. | Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. | 2011 | JPEN J Parenter Enteral Nutr | pmid:21224438 |
| Burrows T et al. | Omega-3 index, obesity and insulin resistance in children. | 2011 | Int J Pediatr Obes | pmid:21226540 |
| Min Y et al. | Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. | 2011 | Eur J Clin Nutr | pmid:21386858 |
| Zhao Y et al. | Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. | 2011 | PLoS ONE | pmid:21246057 |
| Gomez-Pinilla F | The combined effects of exercise and foods in preventing neurological and cognitive disorders. | 2011 | Prev Med | pmid:21281667 |
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| Ueda Y et al. | Effect of dietary lipids on longevity and memory in the SAMP8 mice. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:21512289 |
| Swenne I et al. | Essential fatty acid status in teenage girls with eating disorders and weight loss. | 2011 | Acta Paediatr. | pmid:21362034 |
| Van Dyke TE | Proresolving lipid mediators: potential for prevention and treatment of periodontitis. | 2011 | J. Clin. Periodontol. | pmid:21323709 |
| Harper KN et al. | Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. | 2011 | Schizophr. Res. | pmid:21324652 |
| Grimm MO et al. | Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms. | 2011 | J. Biol. Chem. | pmid:21324907 |
| Umhau JC | Docosahexaenoic acid supplementation and Alzheimer disease. | 2011 | JAMA | pmid:21325181 |
| Nowak M et al. | Impact of polyunsaturated fatty acids on oxidized low density lipoprotein-induced U937 cell apoptosis. | 2011 | J. Atheroscler. Thromb. | pmid:21325776 |
| Murphy RA et al. | Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. | 2011 | Cancer | pmid:21328326 |
| Wang RX et al. | Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. | 2011 | Cardiovasc. Res. | pmid:21187320 |
| Riedel M et al. | Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. | 2011 | J. Mol. Neurosci. | pmid:20725866 |
| Hamazaki K et al. | Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21196723 |
| Cho JY et al. | Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. | 2011 | Mol Nutr Food Res | pmid:20824662 |
| Pawlik D et al. | Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. | 2011 | Pediatrics | pmid:21199856 |
| Lecchi C et al. | In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. | 2011 | Vet. J. | pmid:20889357 |
| Toufektsian MC et al. | Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. | 2011 | J. Nutr. | pmid:21068183 |