Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bourre JM et al. | Fatty acid alterations in liver peroxisomes from n-3-deficient mice. | 2006 | Ann. Nutr. Metab. | pmid:16407648 |
Akbar M et al. | Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation. | 2006 | J. Neurosci. Res. | pmid:16397898 |
Flachs P et al. | Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. | 2006 | Diabetologia | pmid:16397791 |
Onuki Y et al. | Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane. | 2006 | Chem. Pharm. Bull. | pmid:16394552 |
Higuchi T et al. | Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. | 2006 | Ann. Nutr. Metab. | pmid:16391470 |
Butovich IA | A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase. | 2006 | J. Lipid Res. | pmid:16391324 |
Kulkarni A et al. | Successful outcome of pregnancy in a patient with familial hypertriglyceridaemia. | 2006 | J Obstet Gynaecol | pmid:16390715 |
Fang PC et al. | The effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants. | 2005 | Chang Gung Med J | pmid:16382755 |
Sørensen BM et al. | Storage lipid accumulation and acyltransferase action in developing flaxseed. | 2005 | Lipids | pmid:16382576 |
Bryan DL et al. | Modulation of respiratory syncytial virus-induced prostaglandin E2 production by n-3 long-chain polyunsaturated fatty acids in human respiratory epithelium. | 2005 | Lipids | pmid:16382572 |
Hussar DA | New drugs: pregabalin and omega-3-acid ethyl esters. | 2005 Nov-Dec | J Am Pharm Assoc (2003) | pmid:16381426 |
Kumon Y et al. | A new labyrinthulid isolate that produces only docosahexaenoic acid. | 2006 Mar-Apr | Mar. Biotechnol. | pmid:16380808 |
Birch DG | A randomized placebo-controlled clinical trial of docosahexaenoic acid (DHA) supplementation for X-linked retinitis pigmentosa. | 2005 | Retina (Philadelphia, Pa.) | pmid:16374336 |
Robert SS | Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition. | 2006 Mar-Apr | Mar. Biotechnol. | pmid:16372159 |
Vaughan DK et al. | Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. | 2006 | Exp. Eye Res. | pmid:16360150 |
Song C et al. | Existence of lipid microdomains in bilayer of dipalmitoyl phosphatidylcholine (DPPC) and 1-stearoyl-2-docosahexenoyl phosphatidylserine (SDPS) and their perturbation by chlorpromazine: a 13C and 31P solid-state NMR study. | 2006 | Biophys. Chem. | pmid:16356624 |
Agostoni C et al. | Reduced docosahexaenoic acid synthesis may contribute to growth restriction in infants born to mothers who smoke. | 2005 | J. Pediatr. | pmid:16356447 |
Lindskog M et al. | Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress. | 2006 | Int. J. Cancer | pmid:16353135 |
Joardar A et al. | Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. | 2006 | J. Lipid Res. | pmid:16352524 |
Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
Li T et al. | In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. | 2006 | Exp. Neurol. | pmid:16336964 |
Ishigamori H et al. | Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. | 2005 | Mol. Cell. Biochem. | pmid:16335792 |
Kuratko C et al. | Importance of arachidonic acid in long-chain polyunsaturated fatty acid-supplemented infant formula. | 2005 | Am. J. Clin. Nutr. | pmid:16332670 |
Min Y et al. | Unfavorable effect of type 1 and type 2 diabetes on maternal and fetal essential fatty acid status: a potential marker of fetal insulin resistance. | 2005 | Am. J. Clin. Nutr. | pmid:16332647 |
Lyberg AM et al. | Monitoring the oxidation of docosahexaenoic acid in lipids. | 2005 | Lipids | pmid:16329470 |
Saito H et al. | High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker). | 2005 | Lipids | pmid:16329467 |
Patten GS et al. | Dietary fish oil dose-response effects on ileal phospholipid fatty acids and contractility. | 2005 | Lipids | pmid:16329465 |
Sala-Vila A et al. | Influence of dietary source of docosahexaenoic and arachidonic acids on their incorporation into membrane phospholipids of red blood cells in term infants. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16326086 |
Patch CS et al. | The use of novel foods enriched with long-chain n-3 fatty acids to increase dietary intake: a comparison of methodologies assessing nutrient intake. | 2005 | J Am Diet Assoc | pmid:16321598 |
Quilty MC et al. | Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. | 2006 | Exp. Neurol. | pmid:16310772 |
Xiang M et al. | Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: diet, breast milk and infant growth. | 2005 | Acta Paediatr. | pmid:16303692 |
Hong S et al. | Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303609 |
Taber DF and Jackson Roberts L | Nomenclature systems for the neuroprostanes and for the neurofurans. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303600 |
Yanagita T et al. | Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. | 2005 | J. Agric. Food Chem. | pmid:16302788 |
[Long-chain omega-3 fatty acids: highly concentrated only as ethyl ester]. | 2005 | MMW Fortschr Med | pmid:16302427 | |
Florent S et al. | Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers. | 2006 | J. Neurochem. | pmid:16300635 |
Hirunpanich V et al. | Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats. | 2006 | Drug Metab. Dispos. | pmid:16299163 |
Geppert J et al. | Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. | 2005 | Lipids | pmid:16296399 |
Howe P et al. | Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources. | 2006 | Nutrition | pmid:16289978 |
Li HX and Yang GS | [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16285532 |
Friesen R and Innis SM | Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16282365 |
Nirmalananthan N and Greensmith L | Amyotrophic lateral sclerosis: recent advances and future therapies. | 2005 | Curr. Opin. Neurol. | pmid:16280684 |
Umhau JC et al. | The relationship between folate and docosahexaenoic acid in men. | 2006 | Eur J Clin Nutr | pmid:16278690 |
Wu WH et al. | Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women. | 2006 | Eur J Clin Nutr | pmid:16278686 |
Wu K et al. | [Effects of phytohormones on growth and DHA production by Thraustochytrium roseum]. | 2003 | Wei Sheng Wu Xue Bao | pmid:16276880 |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Omega-3 polyunsaturated fatty acids (Omacor) for hypertriglyceridemia. | 2005 | Med Lett Drugs Ther | pmid:16267495 | |
Milatovic D et al. | Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16260380 |
Mihailescu M and Gawrisch K | The structure of polyunsaturated lipid bilayers important for rhodopsin function: a neutron diffraction study. | 2006 | Biophys. J. | pmid:16258049 |
Foran JA et al. | Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. | 2005 | J. Nutr. | pmid:16251623 |
Yu-Poth S et al. | Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells. | 2005 | J. Nutr. | pmid:16251608 |
Chen W et al. | Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16249517 |
Cohen JT et al. | A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development. | 2005 | Am J Prev Med | pmid:16242603 |
Markesbery WR et al. | Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. | 2005 | Ann. Neurol. | pmid:16240347 |
Mjøs SA | Properties of trans isomers of eicosapentaenoic acid and docosahexaenoic acid methyl esters on cyanopropyl stationary phases. | 2005 | J Chromatogr A | pmid:16236287 |
Gregor JI et al. | Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16226437 |
Lloyd-Still JD et al. | Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study. | 2006 | Nutrition | pmid:16226012 |
Botolin D et al. | Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. | 2006 | J. Lipid Res. | pmid:16222032 |
Ly LH et al. | Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16221546 |
Ariel A et al. | The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. | 2005 | J. Biol. Chem. | pmid:16216871 |
Eitsuka T et al. | Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach. | 2005 | Biochim. Biophys. Acta | pmid:16216547 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. | 2005 | Life Sci. | pmid:16214179 |
Marszalek JR and Lodish HF | Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. | 2005 | Annu. Rev. Cell Dev. Biol. | pmid:16212510 |
Flachs P et al. | Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. | 2005 | Diabetologia | pmid:16205884 |
Merendino N et al. | Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. | 2005 | Nutr Cancer | pmid:16201853 |
Pardini RS et al. | Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histiocytoma of the lungs. | 2005 | Nutr Cancer | pmid:16201843 |
Itoh T et al. | Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents. | 2006 | Bioorg. Med. Chem. | pmid:16198578 |
Xiao Y et al. | Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain. | 2005 | Br. J. Nutr. | pmid:16197579 |
Erkkilä AT et al. | Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children. | 2005 | J Craniofac Surg | pmid:16192854 |
Lim SY et al. | N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks. | 2005 | Pediatr. Res. | pmid:16189203 |
Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
Sergeeva M et al. | Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188212 |
Burdge GC and Calder PC | Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188209 |
Stillwell W et al. | Docosahexaenoic acid affects cell signaling by altering lipid rafts. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188208 |
Young GS et al. | Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188207 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188206 |
Dentin R et al. | Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. | 2005 | J. Clin. Invest. | pmid:16184193 |
Bazinet RP et al. | Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. | 2006 | Biol. Psychiatry | pmid:16182257 |
Bazan NG et al. | Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179516 |
Lee HJ et al. | Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. | 2005 | Neurochem. Res. | pmid:16176072 |
Bairati I et al. | Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease. | 1992 Jan-Feb | Can J Cardiol | pmid:1617510 |
Zhao G et al. | Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16169525 |
Lina BA et al. | Subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonate-enriched triglyceride oil (SUNTGA40S) in rats. | 2006 | Food Chem. Toxicol. | pmid:16168548 |
Siddiqui RA et al. | Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells. | 2005 | Breast Cancer Res. | pmid:16168109 |
Hashimoto M et al. | Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16165346 |
Oda E et al. | A case-control pilot study on n-3 polyunsaturated fatty acid as a negative risk factor for myocardial infarction. | 2005 | Int Heart J | pmid:16157949 |
Vaculová A et al. | TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. | 2005 | Cancer Lett. | pmid:16157217 |
Kruger MC and Schollum LM | Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16154334 |
Lee KW et al. | Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. | 2006 | Thromb. Res. | pmid:16154181 |
Lukiw WJ et al. | A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. | 2005 | J. Clin. Invest. | pmid:16151530 |
Butovich IA | On the structure and synthesis of neuroprotectin D1, a novel anti-inflammatory compound of the docosahexaenoic acid family. | 2005 | J. Lipid Res. | pmid:16150835 |
Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
Dalfó E et al. | Evidence of oxidative stress in the neocortex in incidental Lewy body disease. | 2005 | J. Neuropathol. Exp. Neurol. | pmid:16141792 |
Machida T et al. | Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells. | 2005 | J. Pharmacol. Sci. | pmid:16141635 |
Decsi T et al. | Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. | 2005 | Adv. Exp. Med. Biol. | pmid:16137113 |
Lim SY et al. | An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance. | 2005 | J. Neurochem. | pmid:16135079 |
Taha AY et al. | Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. | 2005 | Metab. Clin. Exp. | pmid:16125522 |
Esquenazi S et al. | Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16123410 |
Thiébaut AC et al. | [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. | 2005 | Bull Cancer | pmid:16123005 |
Hart SL et al. | Brief report: newborn behavior differs with decosahexaenoic acid levels in breast milk. | 2006 | J Pediatr Psychol | pmid:16120762 |