Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cao D et al. | Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. | 2005 | J. Nutr. Biochem. | pmid:16115542 |
Donnelly SM et al. | Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients. | 1992 | J. Am. Soc. Nephrol. | pmid:1610984 |
Mahéo K et al. | Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. | 2005 | Free Radic. Biol. Med. | pmid:16109304 |
Li Y et al. | Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis. | 2005 | J. Lipid Res. | pmid:16106047 |
Watkins BA et al. | Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats. | 2006 | J. Nutr. Biochem. | pmid:16102959 |
Calon F et al. | Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. | 2005 | Eur. J. Neurosci. | pmid:16101743 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. | 2006 | J. Nutr. Biochem. | pmid:16098734 |
Demar JC et al. | alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. | 2005 | J. Neurochem. | pmid:16092947 |
Morita N et al. | Cultivation of microorganisms in the cultural medium made from squid internal organs and accumulation of polyunsaturated fatty acids in the cells. | 2005 | Biotechnol. Lett. | pmid:16091889 |
Valenzuela A et al. | Tissue accretion and milk content of docosahexaenoic acid in female rats after supplementation with different docosahexaenoic acid sources. | 2005 Sep-Oct | Ann. Nutr. Metab. | pmid:16088098 |
Rosell MS et al. | Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. | 2005 | Am. J. Clin. Nutr. | pmid:16087975 |
McCann JC and Ames BN | Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. | 2005 | Am. J. Clin. Nutr. | pmid:16087970 |
Wang Y et al. | Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate. | 2005 | Bioorg. Med. Chem. | pmid:16084097 |
Bou R et al. | Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. | 2005 | Poult. Sci. | pmid:16050130 |
Yoshizawa K and Tsubura A | [Characteristics of N-methyl-N-nitrosourea-induced retinal degeneration in animals and application for the therapy of human retinitis pigmentosa]. | 2005 | Nippon Ganka Gakkai Zasshi | pmid:16047940 |
Ajuwon KM and Spurlock ME | Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. | 2005 | J. Nutr. | pmid:16046706 |
André A et al. | Plasmalogen metabolism-related enzymes in rat brain during aging: influence of n-3 fatty acid intake. | 2006 | Biochimie | pmid:16046045 |
Akbar M et al. | Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16040805 |
Feller SE and Gawrisch K | Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin. | 2005 | Curr. Opin. Struct. Biol. | pmid:16039844 |
Leonardi F et al. | Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cells. | 2005 | Free Radic. Res. | pmid:16036367 |
Morais S et al. | Dietary protein:lipid ratio and lipid nature affects fatty acid absorption and metabolism in a teleost larva. | 2005 | Br. J. Nutr. | pmid:16022750 |
Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
Hoff S et al. | Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. | 2005 | Eur J Clin Nutr | pmid:16015268 |
Lu J et al. | [Analysis of fatty acids in tissues of Penaeus vannamei cultured in sea- and fresh-waters by ultrasonic extraction-capillary gas chromatography]. | 2005 | Se Pu | pmid:16013568 |
Heird WC and Lapillonne A | The role of essential fatty acids in development. | 2005 | Annu. Rev. Nutr. | pmid:16011478 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. | 2005 | Pediatr. Res. | pmid:16006428 |
Judé S et al. | Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. | 2006 Jan-Apr | Prog. Biophys. Mol. Biol. | pmid:16005051 |
Jensen CL et al. | Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. | 2005 | Am. J. Clin. Nutr. | pmid:16002810 |
Otsuka K et al. | Comparison of the inhibitory effects of docosahexaenoic acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig aorta. | 2005 | Biol. Pharm. Bull. | pmid:15997118 |
Guizy M et al. | {Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15987770 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Schley PD et al. | Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. | 2005 | Breast Cancer Res. Treat. | pmid:15986129 |
Blankenship J | Increasing maternal docosahexaenoic acid levels. | 2005 | J Am Diet Assoc | pmid:15983528 |
Puglia C et al. | In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts. | 2005 | Int J Pharm | pmid:15979259 |
Tonon T et al. | Fatty acid desaturases from the microalga Thalassiosira pseudonana. | 2005 | FEBS J. | pmid:15978045 |
Ng Y et al. | The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. | 2005 | Carcinogenesis | pmid:15975958 |
Bowen RA and Clandinin MT | Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain. | 2005 | Br. J. Nutr. | pmid:15975158 |
Diau GY et al. | The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. | 2005 | BMC Med | pmid:15975147 |
Min Y et al. | Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. | 2005 | Diabet. Med. | pmid:15975108 |
Tritt KL et al. | Chemometric discrimination among wild and cultured age-0 largemouth bass, black crappies, and white crappies based on fatty acid composition. | 2005 | J. Agric. Food Chem. | pmid:15969511 |
Salem N et al. | Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. | 2005 | Exp. Eye Res. | pmid:15967432 |
Obajimi O et al. | Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. | 2005 | Pharmacol. Res. | pmid:15967385 |
Lu L et al. | Effects of different types of oxidative stress in RPE cells. | 2006 | J. Cell. Physiol. | pmid:15965958 |
Hichami A et al. | Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. | 2005 | Am. J. Respir. Cell Mol. Biol. | pmid:15961724 |
Senkal M et al. | Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue. | 2005 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:15961678 |
Butovich IA et al. | Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid. | 2005 | Lipids | pmid:15957250 |
Liu BH et al. | Effect of docosahexaenoic acid and arachidonic acid on the expression of adipocyte determination and differentiation-dependent factor 1 in differentiating porcine adipocytes. | 2005 | J. Anim. Sci. | pmid:15956459 |
Meng LP et al. | [Relationship between maternal DHA intake and DHA status and development of fetus and infant]. | 2005 | Wei Sheng Yan Jiu | pmid:15952672 |
Seidel A et al. | The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. | 2005 | J Vet Med A Physiol Pathol Clin Med | pmid:15943605 |
Speake BK and Wood NA | Timing of incorporation of docosahexaenoic acid into brain and muscle phospholipids during precocial and altricial modes of avian development. | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15939318 |
Wilkinson P et al. | Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. | 2005 | Atherosclerosis | pmid:15939062 |
Dabadie H et al. | Moderate intake of myristic acid in sn-2 position has beneficial lipidic effects and enhances DHA of cholesteryl esters in an interventional study. | 2005 | J. Nutr. Biochem. | pmid:15936650 |
Li Q et al. | Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. | 2005 | J. Lipid Res. | pmid:15930520 |
Lin YH et al. | Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma. | 2005 | J. Lipid Res. | pmid:15930513 |
Maki KC et al. | Lipid responses to a dietary docosahexaenoic acid supplement in men and women with below average levels of high density lipoprotein cholesterol. | 2005 | J Am Coll Nutr | pmid:15930485 |
Hamazaki K et al. | Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial. | 2005 | Nutrition | pmid:15925295 |
Chen S et al. | Importance of polyunsaturated acyl chains in chlorpromazine interaction with phosphatidylserines: a 13C and 31P solid-state NMR study. | 2005 | Biophys. Chem. | pmid:15921844 |
Duncan RE et al. | Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. | 2005 | Cancer Lett. | pmid:15914273 |
Bazan NG | Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. | 2005 | Brain Pathol. | pmid:15912889 |
Filburn CR and Griffin D | Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. | 2005 | Vet. Ther. | pmid:15906268 |
Van Maldergem L et al. | Orthotopic liver transplantation from a living-related donor in an infant with a peroxisome biogenesis defect of the infantile Refsum disease type. | 2005 | J. Inherit. Metab. Dis. | pmid:15902563 |
Menendez JA et al. | Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. | 2005 | Eur. J. Cancer Prev. | pmid:15901996 |
Dhein S et al. | Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids. | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15900514 |
Yin H et al. | Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. | 2005 | J. Biol. Chem. | pmid:15894799 |
Djoussé L et al. | Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. | 2005 | J. Am. Coll. Cardiol. | pmid:15893192 |
Hirano H et al. | The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages. | 2005 | Oncol. Rep. | pmid:15870941 |
Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
Lim SY et al. | Lead exposure and (n-3) fatty acid deficiency during rat neonatal development affect subsequent spatial task performance and olfactory discrimination. | 2005 | J. Nutr. | pmid:15867275 |
Aïd S et al. | Dietary docosahexaenoic acid [22: 6(n-3)] as a phospholipid or a triglyceride enhances the potassium chloride-evoked release of acetylcholine in rat hippocampus. | 2005 | J. Nutr. | pmid:15867273 |
Carta G et al. | Recurrent miscarriage associated with antiphospholipid antibodies: prophylactic treatment with low-dose aspirin and fish oil derivates. | 2005 | Clin Exp Obstet Gynecol | pmid:15864938 |
Kunesová M et al. | The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. | 2006 | Physiol Res | pmid:15857162 |
Montine TJ and Morrow JD | Fatty acid oxidation in the pathogenesis of Alzheimer's disease. | 2005 | Am. J. Pathol. | pmid:15855630 |
Woods MN | Role of n-3 fatty acids in prevention of disease complications in patients with HIV. | 2005 Jan-Mar | Nutr Clin Care | pmid:15850231 |
Lytle JS et al. | Stability of a commercially prepared fish oil (omega-3 fatty acid) laboratory rodent diet. | 1992 | Nutr Cancer | pmid:1584711 |
Weatherill AR et al. | Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. | 2005 | J. Immunol. | pmid:15843537 |
Innis SM | Essential fatty acid transfer and fetal development. | 2005 | Placenta | pmid:15837071 |
Goyens PL et al. | Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. | 2005 | J. Lipid Res. | pmid:15834128 |
Patten GS et al. | Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil. | 2005 | Lipids | pmid:15825832 |
Abuissa H et al. | Autonomic function, omega-3, and cardiovascular risk. | 2005 | Chest | pmid:15821175 |
Birch EE et al. | Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. | 2005 | Am. J. Clin. Nutr. | pmid:15817866 |
Clandinin MT et al. | Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. | 2005 | J. Pediatr. | pmid:15812447 |
Ren H et al. | Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease. | 2005 | Ann. Hematol. | pmid:15809883 |
Fickl H et al. | Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. | 2005 | Clin. Exp. Immunol. | pmid:15807851 |
Zhang Q and Ma Y | [Determination of EPA and DHA in marine microalgaes by GC]. | 2004 | Se Pu | pmid:15807130 |
Gederaas OA et al. | Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. | 2005 | Photochem. Photobiol. Sci. | pmid:15803209 |
Thomas CP and Heard CM | In vitro transcutaneous delivery of ketoprofen and essential polyunsaturated fatty acids from a fish oil vehicle incorporating 1,8-cineole. | 2005 Jan-Feb | Drug Deliv | pmid:15801715 |
Kim HJ et al. | Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. | 2005 | J. Cell. Physiol. | pmid:15795939 |
Lim GP et al. | A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. | 2005 | J. Neurosci. | pmid:15788759 |
Cha MC et al. | Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity. | 2005 | BMC Pharmacol. | pmid:15788091 |
Araseki M et al. | Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15784975 |
Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
Engler MM et al. | Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). | 2005 | Am. J. Cardiol. | pmid:15781019 |
Berry CB et al. | Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid. | 2005 | Brain Res. | pmid:15777760 |
Simon HB | On call. I was impressed by your July 2004 article on fish oil, and I'm thinking of taking it. I remember that my mother gave me a spoonful of cod liver oil every day. Would it be a good thing for me to have today? | 2005 | Harv Mens Health Watch | pmid:15773012 |
Denkins Y et al. | Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. | 2005 | J. Lipid Res. | pmid:15772428 |
Draganov DI et al. | Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. | 2005 | J. Lipid Res. | pmid:15772423 |
Shim SM et al. | Mercury and omega-3 fatty acids in retail fish sandwiches. | 2005 | J. Food Prot. | pmid:15771197 |
Niu SL et al. | Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. | 2005 | Biochemistry | pmid:15766276 |
Kuipers RS et al. | High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15763440 |
Alessandri JM et al. | Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. | 2004 Nov-Dec | Reprod. Nutr. Dev. | pmid:15762297 |