DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Igarashi M et al. | Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. | 2012 | J. Neurochem. | pmid:22117540 |
| Figueroa JD et al. | Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. | 2012 | J. Neurotrauma | pmid:21970623 |
| Lim SJ et al. | Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. | 2012 | Oncol. Rep. | pmid:22395735 |
| Sørensen IM et al. | Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. | 2012 | Diabetes Metab. Res. Rev. | pmid:22396195 |
| Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
| Meesapyodsuk D and Qiu X | The front-end desaturase: structure, function, evolution and biotechnological use. | 2012 | Lipids | pmid:22009657 |
| Rontoyanni VG et al. | A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA. | 2012 | Br. J. Nutr. | pmid:22348439 |
| Jayashankar S et al. | Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. | 2012 | Environ. Toxicol. Pharmacol. | pmid:22056564 |
| Meldrum SJ et al. | Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial. | 2012 | Br. J. Nutr. | pmid:22348468 |
| Kariv-Inbal Z et al. | The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. | 2012 | J. Alzheimers Dis. | pmid:22057027 |
| Antonietta Ajmone-Cat M et al. | Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. | 2012 | J. Neurosci. Res. | pmid:22057807 |
| Noreen EE and Brandauer J | The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. | 2012 | J Complement Integr Med | pmid:23104856 |
| Kautharapu KB and Jarboe LR | Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). | 2012 | J. Bacteriol. | pmid:23105048 |
| Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
| Tyburczy C et al. | Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. | 2012 | Br. J. Nutr. | pmid:22040360 |
| Schmitt D et al. | Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. | 2012 | Food Chem. Toxicol. | pmid:22898615 |
| Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
| Jackson PA et al. | Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. | 2012 | Biol Psychol | pmid:22020134 |
| An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
| Li N et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22020559 |
| Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
| Samaee SM and Estévez A | Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. | 2012 | J Exp Zool A Ecol Genet Physiol | pmid:22021057 |
| Yang ZH et al. | Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. | 2012 | Lipids Health Dis | pmid:22846384 |
| Jackson PA et al. | No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. | 2012 | Br. J. Nutr. | pmid:21864417 |
| Rockett BD et al. | Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. | 2012 | J. Lipid Res. | pmid:22315394 |
| Hjorth E and Freund-Levi Y | Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22316559 |
| Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
| Deckelbaum RJ et al. | Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. | 2012 | J. Nutr. | pmid:22323767 |
| Harden CJ et al. | Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. | 2012 | Br. J. Nutr. | pmid:22313587 |
| Komatsuzaki N and Shima J | Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22313752 |
| Silva Jde A et al. | Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. | 2012 | Nutr Cancer | pmid:22295891 |
| Mackay I et al. | Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial disease. | 2012 | Atherosclerosis | pmid:22296885 |
| Tan Z et al. | Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. | 2012 | Food Chem | pmid:23442661 |
| Saito H and Ishikawa S | Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii. | 2012 | J Oleo Sci | pmid:23018852 |
| Kirkegaard E et al. | Marine n-3 fatty acids, atrial fibrillation and QT interval in haemodialysis patients. | 2012 | Br. J. Nutr. | pmid:21791142 |
| Lopez HL | Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. | 2012 | PM R | pmid:22632694 |
| O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
| Cazzola R et al. | Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. | 2012 | Exp. Gerontol. | pmid:23000875 |
| Norris PC and Dennis EA | Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586114 |
| Xue C et al. | Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. | 2012 | Lipids | pmid:22120618 |
| Chiu CY et al. | Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. | 2012 | Inflamm. Res. | pmid:22618200 |
| Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
| Pan XX et al. | Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. | 2012 | J. Agric. Food Chem. | pmid:22934819 |
| Zhao M et al. | Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. | 2012 | J. Nutr. | pmid:22955512 |
| Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
| Zicker SC et al. | Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. | 2012 | J. Am. Vet. Med. Assoc. | pmid:22916855 |
| Muldoon MF | Discerning whether and how long-chain, n-3 fatty acids lower blood pressure: a comment on Skulas-Ray et al. | 2012 | Ann Behav Med | pmid:22918613 |
| Zou XQ et al. | Preparation of human milk fat substitutes from palm stearin with arachidonic and docosahexaenoic acid: combination of enzymatic and physical methods. | 2012 | J. Agric. Food Chem. | pmid:22920386 |
| Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Cortina MS et al. | Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. | 2012 | Arch. Ophthalmol. | pmid:21911652 |
| Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
| Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
| Steffen BT et al. | Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). | 2012 | Eur J Clin Nutr | pmid:22215136 |
| Basselin M et al. | Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. | 2012 | Brain Res. Bull. | pmid:22178644 |
| van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
| Odusanwo O et al. | Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22237406 |
| Stein AD et al. | Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. | 2012 | J. Nutr. | pmid:22739364 |
| Virtanen JK et al. | Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. | 2012 | PLoS ONE | pmid:22815906 |
| Thomas MC et al. | Rapid identification of long-chain polyunsaturated fatty acids in a marine extract by HPLC-MS using data-dependent acquisition. | 2012 | Anal. Chem. | pmid:22816781 |
| Deike E et al. | The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. | 2012 | J Ren Nutr | pmid:22285316 |
| Trépanier MO et al. | Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. | 2012 | Epilepsy Res. | pmid:22285511 |
| Signori C et al. | Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. | 2012 | Eur J Clin Nutr | pmid:22669332 |
| Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
| Han CY et al. | NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. | 2012 | J. Biol. Chem. | pmid:22287546 |
| Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
| Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
| Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
| Hacioglu G et al. | Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. | 2012 | Folia Histochem. Cytobiol. | pmid:22763967 |
| Scheltens P et al. | Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. | 2012 | J. Alzheimers Dis. | pmid:22766770 |
| Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
| Moreno-Indias I et al. | Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. | 2012 | J. Anim. Sci. | pmid:22665635 |
| Holly LT et al. | Dietary therapy to promote neuroprotection in chronic spinal cord injury. | 2012 | J Neurosurg Spine | pmid:22735048 |
| Wang DC et al. | Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. | 2012 | Neurobiol. Aging | pmid:20980076 |
| Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
| Baracos VE et al. | Survival: the relevant primary outcome for nutrition therapy in cancer patients. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22466928 |
| Hoffmire CA et al. | Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22472486 |
| Oblozinský M et al. | New pharmaceutical insights related to the pathways of PUFAs. | 2012 | Ceska Slov Farm | pmid:23251954 |
| Liao Z et al. | Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. | 2012 | Respir. Res. | pmid:23199346 |
| Russell FD and Bürgin-Maunder CS | Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. | 2012 | Mar Drugs | pmid:23203276 |
| Trikalinos TA et al. | Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. | 2012 | J Clin Epidemiol | pmid:22047889 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Calder PC and Yaqoob P | Marine omega-3 fatty acids and coronary heart disease. | 2012 | Curr. Opin. Cardiol. | pmid:22565141 |
| Bianchini F et al. | 22Â :Â 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. | 2012 | Br. J. Nutr. | pmid:22390897 |
| Sparvero LJ et al. | Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. | 2012 | Chem. Phys. Lipids | pmid:22692104 |
| Szabó A et al. | Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. | 2012 | Acta. Biol. Hung. | pmid:22695520 |
| Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
| Itakura H et al. | The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. | 2012 | J. Atheroscler. Thromb. | pmid:22653220 |
| Hajjaji N et al. | Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. | 2012 | Cancer Chemother. Pharmacol. | pmid:22610354 |
| Angulo J et al. | Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. | 2012 | J. Sci. Food Agric. | pmid:22549272 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
| Drzymała-Czyż S et al. | Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. | 2012 | Folia Histochem. Cytobiol. | pmid:22532147 |
| Bernstein AM et al. | A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. | 2012 | J. Nutr. | pmid:22113870 |
| Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
| Yui K et al. | Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. | 2012 | J Clin Psychopharmacol | pmid:22370992 |
| Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
| Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |
| Ginty AT and Conklin SM | Preliminary evidence that acute long-chain omega-3 supplementation reduces cardiovascular reactivity to mental stress: a randomized and placebo controlled trial. | 2012 | Biol Psychol | pmid:21967854 |
| Aisen PS et al. | Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. | 2012 | Cold Spring Harb Perspect Med | pmid:22393531 |