Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Meesapyodsuk D and Qiu X | The front-end desaturase: structure, function, evolution and biotechnological use. | 2012 | Lipids | pmid:22009657 |
Ozogul Y et al. | The effects of extraction methods on the contents of fatty acids, especially EPA and DHA in marine lipids. | 2012 | Int J Food Sci Nutr | pmid:22010951 |
Cheon Y et al. | Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice. | 2012 | Biochim. Biophys. Acta | pmid:22349267 |
Poloschek CM and Jägle H | [Pharmacological concepts to treat hereditary retinal degenerations]. | 2012 | Ophthalmologe | pmid:22350547 |
Amann-Gassner U and Hastreiter L | [Nutrition during pregnancy]. | 2012 | MMW Fortschr Med | pmid:22352251 |
Feng GM et al. | Effect of docosahexaenoic acid on hypoxia/reoxygenation injury in human coronary arterial smooth muscle cells. | 2012 | Eur J Nutr | pmid:22105312 |
Siriwardhana N et al. | Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. | 2012 | Adv. Food Nutr. Res. | pmid:22361189 |
Ayas D et al. | The effects of season and sex on fat, fatty acids and protein contents of Sepia officinalis in the northeastern Mediterranean Sea. | 2012 | Int J Food Sci Nutr | pmid:22106841 |
Türkez H et al. | Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. | 2012 | Toxicol Ind Health | pmid:21996711 |
Murphy RA et al. | n-3 polyunsaturated fatty acids: the potential role for supplementation in cancer. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22366922 |
Larsen BM et al. | Pre-treatment with an intravenous lipid emulsion containing fish oil (eicosapentaenoic and docosahexaenoic acid) decreases inflammatory markers after open-heart surgery in infants: a randomized, controlled trial. | 2012 | Clin Nutr | pmid:22136963 |
Itoyama A et al. | Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. | 2012 | J. Cell. Sci. | pmid:22389399 |
Phang M et al. | Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects. | 2012 | J. Nutr. Biochem. | pmid:22137256 |
Zhang MJ and Spite M | Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. | 2012 | Annu. Rev. Nutr. | pmid:22404117 |
Oliver E et al. | Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. | 2012 | J. Nutr. Biochem. | pmid:22137266 |
Hall JC et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. | 2012 | J. Neurochem. | pmid:22404382 |
Nakamoto K et al. | Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. | 2012 | Brain Res. | pmid:22137657 |
Ji A et al. | n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. | 2012 | Neurotoxicology | pmid:22406923 |
Kornfeld S et al. | Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. | 2012 | Carcinogenesis | pmid:22114075 |
Cruz-Hernandez C et al. | Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. | 2012 | Nutrients | pmid:23201848 |
Wang X et al. | The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). | 2012 | PLoS ONE | pmid:23110176 |
Taha AY et al. | Upregulated expression of brain enzymatic markers of arachidonic and docosahexaenoic acid metabolism in a rat model of the metabolic syndrome. | 2012 | BMC Neurosci | pmid:23110484 |
Eady TN et al. | Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats. | 2012 | PLoS ONE | pmid:23118851 |
Judge MP et al. | Maternal consumption of a DHA-containing functional food benefits infant sleep patterning: an early neurodevelopmental measure. | 2012 | Early Hum. Dev. | pmid:22269042 |
Morse NL | Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. | 2012 | Nutrients | pmid:22852064 |
Jørgensen MH et al. | Long-chain PUFA in granulocytes, mononuclear cells, and RBC in patients with cystic fibrosis: relation to liver disease. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22241510 |
Williams JA et al. | Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains. | 2012 | Biophys. J. | pmid:22853900 |
Galli C et al. | Bioequivalence of two omega-3 fatty acid ethyl ester formulations: a case of clinical pharmacology of dietary supplements. | 2012 | Br J Clin Pharmacol | pmid:22242645 |
Fedor DM et al. | Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation. | 2012 | Metab Syndr Relat Disord | pmid:22242926 |
Gutiérrez-Mata AP et al. | [Neurological, neuropsychological, and ophthalmological evolution after one year of docosahexaenoic acid supplementation in phenylketonuric patients]. | 2012 | Rev Neurol | pmid:22829083 |
Lockyer S et al. | SATgenε dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods. | 2012 | Br. J. Nutr. | pmid:22243632 |
Peyronnet R et al. | Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. | 2012 | Cell Rep | pmid:22832196 |
Stanley WC et al. | Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22248591 |
Will BrainStrong boost your brain? | 2012 | Consum Rep | pmid:22891387 | |
Shearer GC et al. | Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial. | 2012 | J. Lipid Res. | pmid:22892157 |
Lauritzen L et al. | Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. | 2012 | Br. J. Nutr. | pmid:21736784 |
Brown SP et al. | Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. | 2012 | ACS Med Chem Lett | pmid:24900539 |
Kitson AP et al. | Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet. | 2012 | Appl Physiol Nutr Metab | pmid:23050796 |
Quan-Xin F et al. | Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn. | 2012 | BMC Gastroenterol | pmid:23092159 |
Ritter JC and Budge SM | Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. | 2012 | Lipids | pmid:23096224 |
Jackson KG et al. | Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype-insights from the SATgenε study. | 2012 | Mol Nutr Food Res | pmid:23097177 |
Liu Y et al. | Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. | 2012 | J. Nutr. | pmid:23014495 |
Serini S et al. | EPA and DHA differentially affect in vitro inflammatory cytokine release by peripheral blood mononuclear cells from Alzheimer's patients. | 2012 | Curr Alzheimer Res | pmid:22299617 |
Damsgaard CT et al. | The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys. | 2012 | Pediatr. Res. | pmid:22337227 |
Burillo E et al. | Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease? | 2012 | Curr Vasc Pharmacol | pmid:22339302 |
Serhan CN et al. | Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. | 2012 | FASEB J. | pmid:22253477 |
Sundrani DP et al. | Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. | 2012 | PLoS ONE | pmid:22253805 |
Tian H et al. | 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. | 2012 | Stem Cells Dev. | pmid:21846180 |
Norris PC and Dennis EA | Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586114 |
Chiu CY et al. | Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. | 2012 | Inflamm. Res. | pmid:22618200 |
Ramadeen A et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation. | 2012 | Circ Arrhythm Electrophysiol | pmid:22923273 |
Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
Richardson AJ et al. | Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). | 2012 | PLoS ONE | pmid:22970149 |
Rasti B et al. | Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari methods. | 2012 | Food Chem | pmid:22980870 |
Moore RL et al. | Oxidative stability of an extended shelf-life dairy-based beverage system designed to contribute to heart health. | 2012 | J. Dairy Sci. | pmid:22981572 |
Adolph S et al. | Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. | 2012 | Curr. Microbiol. | pmid:22903555 |
Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
Yakunin E et al. | Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. | 2012 | Brain Pathol. | pmid:21929559 |
Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
Chen WY et al. | Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. | 2012 | J. Nutr. Biochem. | pmid:21497498 |
Chen HF and Su HM | Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. | 2012 | J. Nutr. Biochem. | pmid:21543216 |
Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
Thomas MC et al. | Rapid identification of long-chain polyunsaturated fatty acids in a marine extract by HPLC-MS using data-dependent acquisition. | 2012 | Anal. Chem. | pmid:22816781 |
Ramon S et al. | Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. | 2012 | J. Immunol. | pmid:22711890 |
Connor S et al. | DHA supplementation enhances high-frequency, stimulation-induced synaptic transmission in mouse hippocampus. | 2012 | Appl Physiol Nutr Metab | pmid:22716290 |
Angulo J et al. | Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. | 2012 | Animal | pmid:22717104 |
Basak S and Duttaroy AK | Leptin induces tube formation in first-trimester extravillous trophoblast cells. | 2012 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:22717511 |
Ewaschuk JB et al. | Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. | 2012 | Lipids | pmid:23054549 |
Schott CK and Huang DT | ω-3 fatty acids, γ-linolenic acid, and antioxidants: immunomodulators or inert dietary supplements? | 2012 | Crit Care | pmid:23176247 |
Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
Kuipers RS et al. | Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425684 |
Sakamoto M et al. | Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. | 2012 | Environ Int | pmid:22425897 |
Dornstauder B et al. | Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22427551 |
de Goede J et al. | Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. | 2012 | PLoS ONE | pmid:22496770 |
Huang LT et al. | Fatty acid composition of 12 fish species from the Black Sea. | 2012 | J. Food Sci. | pmid:22497457 |
Turan D et al. | Production of human milk fat analogue containing docosahexaenoic and arachidonic acids. | 2012 | J. Agric. Food Chem. | pmid:22497589 |
Donohue MC and Aisen PS | Mixed model of repeated measures versus slope models in Alzheimer's disease clinical trials. | 2012 | J Nutr Health Aging | pmid:22499459 |
Norling LV et al. | Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22499990 |
Sczaniecka AK et al. | Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. | 2012 | Nutr Cancer | pmid:23137008 |
Jiang LH et al. | Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice. | 2012 | Eur Rev Med Pharmacol Sci | pmid:23208960 |
Sigal LH | Basic science for the clinician 59: polymorphonuclear cells: mechanisms in human defense and in the pathogenesis of autoimmune disease. | 2012 | J Clin Rheumatol | pmid:23211587 |
Sciotto C and Mjøs SA | Trans isomers of EPA and DHA in omega-3 products on the European market. | 2012 | Lipids | pmid:22566205 |
Duda MK | [Polyunsaturated fatty acids omega-3 as modulators of intracellular signaling pathways]. | 2012 | Postepy Biochem. | pmid:23214138 |
Das UN | Is multiple sclerosis a proresolution deficiency disorder? | 2012 | Nutrition | pmid:22521616 |
Szabó A et al. | Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. | 2012 | Acta. Biol. Hung. | pmid:22695520 |
Zheng JS et al. | Low docosahexaenoic acid content in plasma phospholipids is associated with increased non-alcoholic fatty liver disease in China. | 2012 | Lipids | pmid:22527845 |
Aldai N et al. | Evaluating the in vitro metabolism of docosahexaenoic acid in sheep rumen fluid. | 2012 | Lipids | pmid:22695744 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Patterson AC et al. | Biomarker and dietary validation of a Canadian food frequency questionnaire to measure eicosapentaenoic and docosahexaenoic acid intakes from whole food, functional food, and nutraceutical sources. | 2012 | J Acad Nutr Diet | pmid:22583924 |
Balakumar P and Taneja G | Fish oil and vascular endothelial protection: bench to bedside. | 2012 | Free Radic. Biol. Med. | pmid:22584102 |
Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
Mandal CC et al. | miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression. | 2012 | Carcinogenesis | pmid:22678116 |
Harris WS et al. | Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans. | 2012 | J. Nutr. | pmid:22623386 |
GarcÃa-RodrÃguez CE et al. | Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake. | 2012 | J. Nutr. | pmid:22623389 |
Rossmeisl M et al. | Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. | 2012 | PLoS ONE | pmid:22701720 |
Xiong A et al. | Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:22707267 |
Carter JR et al. | Fish oil and neurovascular control in humans. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22707560 |
Phang M et al. | Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20708391 |
Lee HN and Surh YJ | Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. | 2012 | Biochem. Pharmacol. | pmid:23330154 |
Settimio R et al. | Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis. | 2012 | Mediators Inflamm. | pmid:23304060 |