Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Cox R et al. | Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. | 2015 | PLoS ONE | pmid:26317859 |
Qin Y et al. | Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | 2015 | PLoS ONE | pmid:26226139 |
Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
Jansen D et al. | Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. | 2013 | PLoS ONE | pmid:24086523 |
Abdelmoaty S et al. | Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. | 2013 | PLoS ONE | pmid:24086560 |
Musto AE et al. | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. | 2015 | PLoS ONE | pmid:25617763 |
Villalpando DM et al. | Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. | 2017 | PLoS ONE | pmid:28968462 |
Chatterjee A et al. | The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. | 2014 | PLoS ONE | pmid:25409514 |
Abe E et al. | Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. | 2014 | PLoS ONE | pmid:25090090 |
O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
Joseph MS et al. | Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. | 2012 | PLoS ONE | pmid:22911773 |
Zúñiga J et al. | N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. | 2011 | PLoS ONE | pmid:22174823 |
Santos-Soto IJ et al. | Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. | 2013 | PLoS ONE | pmid:24349072 |
Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
Virtanen JK et al. | Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. | 2012 | PLoS ONE | pmid:22815906 |
Katakura M et al. | Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. | 2015 | PLoS ONE | pmid:26485038 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Lachance C et al. | Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. | 2013 | PLoS ONE | pmid:24069363 |
Bahety P et al. | Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. | 2014 | PLoS ONE | pmid:24587236 |
de Waal H et al. | The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. | 2014 | PLoS ONE | pmid:24475144 |
Desai A et al. | Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. | 2014 | PLoS ONE | pmid:24475126 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
Lopez HL | Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. | 2012 | PM R | pmid:22632694 |
Luczaj W and Skrzydlewska E | [The present-day look at lipid peroxidation]. | 2006 | Postepy Biochem. | pmid:17078507 |
Duda MK | [Polyunsaturated fatty acids omega-3 as modulators of intracellular signaling pathways]. | 2012 | Postepy Biochem. | pmid:23214138 |
Walczewska A et al. | [The role of docosahexaenoic acid in neuronal function]. | 2011 | Postepy Hig Med Dosw (Online) | pmid:21677356 |
Crandell JR et al. | Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. | 2016 | Postgrad Med | pmid:27684412 |
Leaf DA | Omega-3 fatty acids and coronary artery disease. More than a fish tale. | 1989 | Postgrad Med | pmid:2542914 |
Sadovsky R and Kris-Etherton P | Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. | 2009 | Postgrad Med | pmid:19641280 |
Harris WS et al. | Omega-3 fatty acids and cardiovascular disease: new developments and applications. | 2013 | Postgrad Med | pmid:24200766 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Pappas AC et al. | Maternal organo-selenium compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the chick tissues. | 2006 | Poult. Sci. | pmid:16977847 |
Meluzzi A et al. | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. | 2000 | Poult. Sci. | pmid:10780651 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Ko YH et al. | Cloning and expression of Tsaiya duck liver fatty acid binding protein. | 2004 | Poult. Sci. | pmid:15554058 |
Grobas S et al. | Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens. | 2001 | Poult. Sci. | pmid:11495470 |
Cherian G and Sim J | Preferential accumulation of n-3 fatty acids in the brain of chicks from eggs enriched with n-3 fatty acids. | 1992 | Poult. Sci. | pmid:1454683 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Surai PF and Sparks NH | Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. | 2000 | Poult. Sci. | pmid:10947182 |
Koppenol A et al. | Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. | 2014 | Poult. Sci. | pmid:24604849 |
Bou R et al. | Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. | 2005 | Poult. Sci. | pmid:16050130 |
López-Ferrer S et al. | n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil. | 2001 | Poult. Sci. | pmid:11441841 |
Wang YW et al. | Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. | 2002 | Poult. Sci. | pmid:12455601 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Allen PC and Danforth HD | Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. | 1998 | Poult. Sci. | pmid:9835336 |
Gao YC and Charter EA | Nutritionally important fatty acids in hen egg yolks from different sources. | 2000 | Poult. Sci. | pmid:10875777 |
Szabó A et al. | Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. | 2005 | Poult. Sci. | pmid:15685949 |
Houston L | Dietary change in arthritis. | 1994 | Practitioner | pmid:8208662 |
Mourek J | Metabolic syndrome (does it have a common denominator?). | 2008 | Prague Med Rep | pmid:19548590 |
Muramatsu T et al. | Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. | 2010 May-Jun | Prev Med | pmid:20211645 |
Gomez-Pinilla F | The combined effects of exercise and foods in preventing neurological and cognitive disorders. | 2011 | Prev Med | pmid:21281667 |
Mori TA | Dietary n-3 PUFA and CVD: a review of the evidence. | 2014 | Proc Nutr Soc | pmid:24119287 |
von Schacky C | n-3 PUFA in CVD: influence of cytokine polymorphism. | 2007 | Proc Nutr Soc | pmid:17466099 |
Sijben JW and Calder PC | Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. | 2007 | Proc Nutr Soc | pmid:17466105 |
Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
Anil E | The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. | 2007 | Proc Nutr Soc | pmid:17343773 |
Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
Ian Givens D and Gibbs RA | Current intakes of EPA and DHA in European populations and the potential of animal-derived foods to increase them. | 2008 | Proc Nutr Soc | pmid:18498671 |
Childs CE et al. | Gender differences in the n-3 fatty acid content of tissues. | 2008 | Proc Nutr Soc | pmid:18234128 |
Calder PC | Dietary modification of inflammation with lipids. | 2002 | Proc Nutr Soc | pmid:12296294 |
Yaqoob P | Fatty acids and the immune system: from basic science to clinical applications. | 2004 | Proc Nutr Soc | pmid:15070442 |
Wainwright PE | Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. | 2002 | Proc Nutr Soc | pmid:12002796 |
Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
Cottin SC et al. | The differential effects of EPA and DHA on cardiovascular risk factors. | 2011 | Proc Nutr Soc | pmid:21349231 |
Williams CM and Burdge G | Long-chain n-3 PUFA: plant v. marine sources. | 2006 | Proc Nutr Soc | pmid:16441943 |
Gibbs RA et al. | Postgraduate Symposium: Long-chain n-3 PUFA: intakes in the UK and the potential of a chicken meat prototype to increase them. | 2010 | Proc Nutr Soc | pmid:19954567 |
Calder PC | Long-chain fatty acids and inflammation. | 2012 | Proc Nutr Soc | pmid:22369781 |
Kelley DS and Adkins Y | Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. | 2012 | Proc Nutr Soc | pmid:22369859 |
Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
Freedman SD et al. | A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570187 |
He C et al. | Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19549874 |
Hoshi T et al. | Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²âº-dependent K⺠channels. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487785 |
Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
Pepe S et al. | Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7522322 |
Scott BL and Bazan NG | Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2523075 |
Kang JX and Leaf A | Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937911 |
Massaro M et al. | The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17018645 |
Mukherjee PK et al. | Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15152078 |
Berger A et al. | Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353819 |
Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Akbar M et al. | Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16040805 |
Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
Honoré E et al. | External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8127910 |
Bruno MJ et al. | Docosahexaenoic acid alters bilayer elastic properties. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17535898 |
Billman GE et al. | Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8183925 |