DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sullivan DR et al. | Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil. | 1986 | Atherosclerosis | pmid:3753548 |
| Thiery J and Seidel D | Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3827970 |
| Simons LA et al. | On the effects of dietary n-3 fatty acids (Maxepa) on plasma lipids and lipoproteins in patients with hyperlipidaemia. | 1985 | Atherosclerosis | pmid:3888229 |
| Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
| Skorepa J et al. | [The effect of fish oils on plasma lipid levels in hyperlipidemics]. | 1985 | Cas. Lek. Cesk. | pmid:3896497 |
| Cendrowski W | [MaxEpa in multiple sclerosis]. | 1985 | Wiad. Lek. | pmid:3913158 |
| Cartwright IJ et al. | The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. | 1985 | Atherosclerosis | pmid:4015748 |
| Karmali RA et al. | Effect of omega-3 fatty acids on growth of a rat mammary tumor. | 1984 | J. Natl. Cancer Inst. | pmid:6087007 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Sanders TA | Dietary polyunsaturated fatty acids and health. | 1984 | Br J Clin Pract Suppl | pmid:6091718 |
| Bazan HE et al. | De novo biosynthesis of docosahexaenoyl-phosphatidic acid in bovine retinal microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6091768 |
| Lee TH et al. | Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. | 1984 | J. Clin. Invest. | pmid:6096400 |
| Kobatake Y et al. | Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6096527 |
| Singer P et al. | Clinical studies on lipid and blood pressure lowering effect of eicosa-pentaenoic acid-rich diet. | 1984 | Biomed. Biochim. Acta | pmid:6097237 |
| Iritani N et al. | Identification of shellfish fatty acids and their effects on lipogenic enzymes. | 1980 | Biochim. Biophys. Acta | pmid:6104986 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Hsia JC et al. | alpha-fetoprotein binding specificity for arachidonate, bilirubin, docosahexaenoate, and palmitate. A spin label study. | 1980 | J. Biol. Chem. | pmid:6154708 |
| Nagai M et al. | The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera. | 1982 | Oncodev. Biol. Med. | pmid:6183647 |
| Guffy MM et al. | Effect of cellular fatty acid alteration on hyperthermic sensitivity in cultured L1210 murine leukemia cells. | 1982 | Cancer Res. | pmid:6213296 |
| Talesnik J and Hsia JC | Coronary flow reactions to arachidonic acid are inhibited by docosahexaenoic acid. | 1982 | Eur. J. Pharmacol. | pmid:6213418 |
| Bazan NG et al. | High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. | 1982 | Biochim. Biophys. Acta | pmid:6215065 |
| Mooibroek J et al. | Comparison of the radiosensitivity of unsaturated fatty acids, structured as micelles or liposomes, under different experimental conditions. | 1982 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6219072 |
| Aveldaño MI and Sprecher H | Synthesis of hydroxy fatty acids from 4, 7, 10, 13, 16, 19-[1-14C] docosahexaenoic acid by human platelets. | 1983 | J. Biol. Chem. | pmid:6223928 |
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Rao GH et al. | Effect of docosahexaenoic acid (DHA) on arachidonic acid metabolism and platelet function. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6229254 |
| Fogerty AC et al. | Liver fatty acids and the sudden infant death syndrome. | 1984 | Am. J. Clin. Nutr. | pmid:6230001 |
| Onuma Y et al. | Selective incorporation of docosahexaenoic acid in rat brain. | 1984 | Biochim. Biophys. Acta | pmid:6231055 |
| Guffy MM et al. | Effect of cellular fatty acid alteration on adriamycin sensitivity in cultured L1210 murine leukemia cells. | 1984 | Cancer Res. | pmid:6231987 |
| Goosey JD et al. | A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases. | 1984 | Invest. Ophthalmol. Vis. Sci. | pmid:6232239 |
| VanRollins M et al. | Oxidation of docosahexaenoic acid by rat liver microsomes. | 1984 | J. Biol. Chem. | pmid:6232277 |
| VanRollins M and Murphy RC | Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. | 1984 | J. Lipid Res. | pmid:6234372 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
| Harris WS et al. | Will dietary omega-3 fatty acids change the composition of human milk? | 1984 | Am. J. Clin. Nutr. | pmid:6237575 |
| Reddy TS et al. | Long-chain acyl-coenzyme A synthetase from rat brain microsomes. Kinetic studies using [1-14C]docosahexaenoic acid substrate. | 1984 | Eur. J. Biochem. | pmid:6237910 |
| Bazan NG et al. | Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6240268 |
| Sanders TA et al. | Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. | 1981 | Clin. Sci. | pmid:6266735 |
| De Schrijver R and Privett OS | Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | 1982 | J. Nutr. | pmid:6279803 |
| Mai J et al. | A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. | 1981 | Prostaglandins | pmid:6280241 |
| Studies of docosahexaenoic and eicosapentaenoic acids in trout and frogs. | 1982 | Nutr. Rev. | pmid:6289203 | |
| Sanders TA and Roshanai F | The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. | 1983 | Clin. Sci. | pmid:6295686 |
| Corey EJ et al. | Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6304720 |
| Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
| Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
| Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
| Fischer S et al. | Uptake, release and metabolism of docosahexaenoic acid (DHA, c22:6 omega 3) in human platelets and neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329189 |
| Bruckner GG et al. | Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. | 1984 | Thromb. Res. | pmid:6330927 |
| Castledine AJ and Buckley JT | Distribution and mobility of omega 3 fatty acids in rainbow trout fed varying levels and types of dietary lipid. | 1980 | J. Nutr. | pmid:6445002 |
| Giesing M and Zilliken F | Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter. | 1980 | Neurochem. Res. | pmid:6445512 |
| Sanders TA and Naismith DJ | The metabolism of alpha-linolenic acid by the foetal rat. | 1980 | Br. J. Nutr. | pmid:6448628 |
| Nissen HP et al. | [Significance of bound fatty acids in human sperm in fertility disorders]. | 1981 Sep-Oct | Andrologia | pmid:6459043 |
| Organisciak DT et al. | Rod outer segment lipid--opsin ratios in the developing normal and retinal dystrophic rat. | 1982 | Exp. Eye Res. | pmid:6461559 |
| Armstrong D et al. | Studies on experimentally induced retinal degeneration. 1. Effect of lipid peroxides on electroretinographic activity in the albino rabbit. | 1982 | Exp. Eye Res. | pmid:7151884 |
| Okita M et al. | n-3 and n-6 fatty acid intake and serum phospholipid fatty acid composition in middle-aged women living in rural and urban areas in Okayama Prefecture. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7472676 |
| Koletzko B et al. | Effects of a low birthweight infant formula containing human milk levels of docosahexaenoic and arachidonic acids. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7472907 |
| Peet M et al. | Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients. | 1995 May-Jun | J Psychiatr Res | pmid:7473298 |
| Van den Branden C et al. | Peroxisomes in mice fed a diet supplemented with low doses of fish oil. | 1995 | Lipids | pmid:7475984 |
| Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
| Toft I et al. | Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. | 1995 | Ann. Intern. Med. | pmid:7486485 |
| Hrelia S et al. | Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488075 |
| Sadou H et al. | Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans. | 1995 | Am. J. Clin. Nutr. | pmid:7491879 |
| Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
| Bankey P et al. | Liposomes modulate Kupffer cell endotoxin response. | 1995 | Arch Surg | pmid:7492273 |
| Farquharson J et al. | Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. | 1995 | Pediatr. Res. | pmid:7494660 |
| Ruan C et al. | Milk composition in women from five different regions of China: the great diversity of milk fatty acids. | 1995 | J. Nutr. | pmid:7500177 |
| Sasaki YF et al. | Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil--docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid--in cultured Chinese hamster cells. | 1994 | Mutat. Res. | pmid:7506391 |
| Nishikawa M et al. | Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. | 1994 | J. Physiol. (Lond.) | pmid:7514666 |
| Pepe S et al. | Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7522322 |
| De Caterina R et al. | The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. | 1994 | Arterioscler. Thromb. | pmid:7524649 |
| Weber C et al. | Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7538427 |
| De Caterina R et al. | Omega-3 fatty acids and endothelial leukocyte adhesion molecules. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7540306 |
| Al MD et al. | Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. | 1995 | Br. J. Nutr. | pmid:7547829 |
| Maldjian A et al. | The transfer of docosahexaenoic acid from the yolk to the tissues of the chick embryo. | 1995 | Biochim. Biophys. Acta | pmid:7548187 |
| Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
| Rhodes LE et al. | Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption. | 1995 | J. Invest. Dermatol. | pmid:7561154 |
| Rapoport SI | Docosahexaenoate turnover in brain phospholipids. | 1995 | J. Neurochem. | pmid:7561892 |
| Siscovick DS et al. | Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. | 1995 | JAMA | pmid:7563561 |
| Clark RM and She L | Lymphatic fatty acids from rats fed human milk and formula supplemented with fish oil. | 1995 | Lipids | pmid:7564923 |
| Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
| Marckmann P et al. | Biomarkers of habitual fish intake in adipose tissue. | 1995 | Am. J. Clin. Nutr. | pmid:7572741 |
| Burdon RH et al. | Hydrogen peroxide and the proliferation of BHK-21 cells. | 1995 | Free Radic. Res. | pmid:7581830 |
| Oshima M et al. | Effects of docosahexaenoic acid (DHA) on intestinal polyp development in Apc delta 716 knockout mice. | 1995 | Carcinogenesis | pmid:7586174 |
| Fujita T et al. | Effects of fatty acids and fatty acyl CoA esters on Cu(2+)-induced conversion of xanthine dehydrogenase to oxidase in rabbit liver. | 1995 | Free Radic. Biol. Med. | pmid:7590398 |
| Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: II. Duration of 15% dietary flaxseed. | 1995 | J. Anim. Sci. | pmid:7592083 |
| Schaefer EJ et al. | Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa. | 1995 | J. Lipid Res. | pmid:7595066 |
| Green P and Yavin E | Modulation of fetal rat brain and liver phospholipid content by intraamniotic ethyl docosahexaenoate administration. | 1995 | J. Neurochem. | pmid:7595551 |
| Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |
| Fournier A et al. | Influence of the phospholipid content in docosahexaenoic acid on electrophysiology and contraction of rat heart muscle cells. | 1995 | Cardioscience | pmid:7605899 |
| Engler MB et al. | Vasorelaxant properties of n-3 polyunsaturated fatty acids in aortas from spontaneously hypertensive and normotensive rats. | 1994 | J Cardiovasc Risk | pmid:7614421 |
| Uauy R and De Andraca I | Human milk and breast feeding for optimal mental development. | 1995 | J. Nutr. | pmid:7623166 |
| Stordy BJ | Benefit of docosahexaenoic acid supplements to dark adaptation in dyslexics. | 1995 | Lancet | pmid:7623560 |
| Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
| VanRollins M | Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7636743 |
| Bell MV et al. | Dietary deficiency of docosahexaenoic acid impairs vision at low light intensities in juvenile herring (Clupea harengus L.). | 1995 | Lipids | pmid:7637565 |
| Wakabayashi S et al. | In vivo imaging of brain incorporation of fatty acids and of 2-deoxy-D-glucose demonstrates functional and structural neuroplastic effects of chronic unilateral visual deprivation in rats. | 1995 | Brain Res. | pmid:7648253 |
| Agostoni C et al. | Docosahexaenoic acid status and developmental quotient of healthy term infants. | 1995 | Lancet | pmid:7651024 |
| Lee J et al. | Soluble-binding proteins for docosahexaenoic acid are present in neural retina. | 1995 | Invest. Ophthalmol. Vis. Sci. | pmid:7657541 |
| Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
| Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
| Sanjurjo P et al. | Influence of fatty fish intake during pregnancy in the polyunsaturated fatty acids of erythrocyte phospholipids in the mother at labor and newborn infant. | 1995 | Acta Obstet Gynecol Scand | pmid:7660762 |