DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agren JJ et al. | Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430389 |
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| Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
| Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
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| Suzuki R et al. | Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054914 |
| von Schacky C | Cardiovascular disease prevention and treatment. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520557 |
| Lii CK et al. | Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774170 |
| Bazan NG | Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520558 |
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| Dalton A et al. | A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19201180 |
| Schuchardt JP et al. | Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21862301 |
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| Du Plooy WJ et al. | The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409770 |
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| Mohan IK and Das UN | Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089797 |
| Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
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| Rapoport SI et al. | Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060754 |
| Mukherjee PK et al. | Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060755 |
| Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
| Koletzko B et al. | Does dietary DHA improve neural function in children? Observations in phenylketonuria. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19615874 |
| Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
| Russell KL et al. | Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23796971 |
| Horrocks LA and Farooqui AA | Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041028 |
| Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
| Rapoport SI | Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973997 |
| Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Erdogan H et al. | Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15253883 |
| van Goor SA et al. | The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21316208 |
| Krabbendam L et al. | Relationship between DHA status at birth and child problem behaviour at 7 years of age. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17074476 |
| Qin X et al. | Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26802938 |
| Hall JA et al. | Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17081738 |
| Ly LH et al. | Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16221546 |
| Brenner RR | Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538079 |
| Fortier M et al. | Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism? | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206489 |
| Jolly CA et al. | Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654402 |
| Raza Shaikh S | Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207118 |
| Kim HY et al. | Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207120 |
| Minns LM et al. | Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207123 |
| Sarri KO et al. | Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18258421 |
| de Groot RH et al. | Exploratory study into the relation between plasma phospholipid fatty acid status and cognitive performance. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17317131 |
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| Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
| Parletta N et al. | Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23756346 |
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| Das UN | Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824535 |
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| Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
| Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
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| Marzo I et al. | Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888202 |
| Yusof HM et al. | Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18403189 |
| Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
| Frøyland L et al. | Hypotriacylglycerolemic component of fish oil. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430383 |