DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Deficiency Diseases D003677 12 associated lipids
Listeriosis D008088 12 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Pain, Postoperative D010149 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Critical Illness D016638 13 associated lipids
Angina, Unstable D000789 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Hegarty B and Parker G Fish oil as a management component for mood disorders - an evolving signal. 2013 Curr Opin Psychiatry pmid:23108232
Ren LJ et al. Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. 2013 Bioprocess Biosyst Eng pmid:23108442
Abdelmoaty S et al. Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. 2013 PLoS ONE pmid:24086560
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Bazan NG et al. Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. 2013 Nestle Nutr Inst Workshop Ser pmid:24107502
Fiol-deRoque MA et al. Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. 2013 Biogerontology pmid:24114505
Olson MV et al. Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. 2013 Inflamm. Res. pmid:24008816
MacLean E et al. n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. 2013 Br. J. Nutr. pmid:22849952
Hajjaji N and Bougnoux P Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. 2013 Cancer Treat. Rev. pmid:22850619
Yang T et al. N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. 2013 J. Nutr. Biochem. pmid:22854319
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. 2013 Med Lett Drugs Ther pmid:23836343
Morais S et al. Effect of Senegalese sole broodstock nutrition on early larval performance and metabolism of long-chain polyunsaturated fatty acids (DHA and EPA). 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141693
Paz-Raymundo B et al. Effect of DHA on the expression of the delta6-desaturase during larval development of yellow snapper, Lutjanus argentiventris. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141709
Kasuya F et al. Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. 2013 J Enzyme Inhib Med Chem pmid:22299587
Lapillonne A et al. Lipid needs of preterm infants: updated recommendations. 2013 J. Pediatr. pmid:23445847
West AA et al. Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. 2013 Am. J. Clin. Nutr. pmid:23446897
Sánchez-Martín MJ et al. Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. 2013 Chembiochem pmid:23447332
Dacks PA et al. Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. 2013 J Nutr Health Aging pmid:23459977
Miyata J et al. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. 2013 J. Allergy Clin. Immunol. pmid:23006546
Goustard-Langelier B et al. Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. 2013 J. Nutr. Biochem. pmid:23036607
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Kaur G et al. Orally administered [¹⁴C]DPA and [¹⁴C]DHA are metabolised differently to [¹⁴C]EPA in rats. 2013 Br. J. Nutr. pmid:22578196
Randall KM et al. Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23867781
Saha SS and Ghosh M Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. 2013 Nutrition pmid:23422533
Ammann EM et al. ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. 2013 Neurology pmid:24068783
Araújo JR et al. Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. 2013 J. Nutr. Biochem. pmid:23790250
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Rahman MM et al. DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. 2013 Breast Cancer Res. Treat. pmid:24062211
Xue Z et al. Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. 2013 Nat. Biotechnol. pmid:23873085
Wijendran V et al. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24075244
Pase MP and Stough C Describing a taxonomy of cognitive processes for clinical trials assessing cognition. 2013 Am. J. Clin. Nutr. pmid:23873682
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Kuratko CN et al. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. 2013 Nutrients pmid:23877090
Vigerust NF et al. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. 2013 Eur J Nutr pmid:22923017
Marty-Roix R and Lien E (De-) oiling inflammasomes. 2013 Immunity pmid:23809158
Stonehouse W et al. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. 2013 Am. J. Clin. Nutr. pmid:23515006
Fagan P and Wijesundera C Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. 2013 J Sep Sci pmid:23559561
Jans JJ et al. Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. 2013 Mol. Genet. Metab. pmid:23562298
Faxén-Irving G et al. Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. 2013 J. Alzheimers Dis. pmid:23563245
Arnold C et al. Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. 2013 JAMA Ophthalmol pmid:23519529
Xu MX et al. Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. 2013 CNS Neurosci Ther pmid:23521911
Guo B et al. Identification and heterologous expression of a Δ4-fatty acid desaturase gene from Isochrysis sphaerica. 2013 J. Microbiol. Biotechnol. pmid:23851273
Oelrich B et al. Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. 2013 Nutr Metab Cardiovasc Dis pmid:21924882
Lundström SL et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. 2013 Mol Nutr Food Res pmid:23824870
Lohner S et al. Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. 2013 Nutr Res pmid:23827125
Kelly OJ et al. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. 2013 Nutr Res pmid:23827126
García-Sastre A Lessons from lipids in the fight against influenza. 2013 Cell pmid:23827671
Birch DG et al. Spectral-domain optical coherence tomography measures of outer segment layer progression in patients with X-linked retinitis pigmentosa. 2013 JAMA Ophthalmol pmid:23828615
Mobraten K et al. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. 2013 Lipids Health Dis pmid:23849180
Aslan M et al. LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. 2013 Lipids Health Dis pmid:24195588
Chen HF and Su HM Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. 2013 J. Nutr. Biochem. pmid:22818715
Brahmbhatt V et al. Protective effects of dietary EPA and DHA on ischemia-reperfusion-induced intestinal stress. 2013 J. Nutr. Biochem. pmid:22819560
Willatts P et al. Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. 2013 Am. J. Clin. Nutr. pmid:23783296
Meyer BJ et al. Improvement of major depression is associated with increased erythrocyte DHA. 2013 Lipids pmid:23733443
Zawadzki M et al. Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. 2013 Mar Drugs pmid:23739042
Morel PC et al. Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. 2013 Meat Sci. pmid:23739265
Liu Y et al. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. 2013 J. Nutr. pmid:23739309
Nobre ME et al. Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. 2013 Nutr Res pmid:23684444
Xu ZZ et al. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. 2013 Ann. Neurol. pmid:23686636
Flock MR et al. Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. 2013 Diabetes Metab. Res. Rev. pmid:23592441
Nagachinta S and Akoh CC Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. 2013 J. Agric. Food Chem. pmid:23597247
Mortensen K and Tawia S Sustained breastfeeding. 2013 Breastfeed Rev pmid:23600325
Harsløf LB et al. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. 2013 Am. J. Clin. Nutr. pmid:23636240
Gordon WC and Bazan NG Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. 2013 Curr. Eye Res. pmid:23981028
Elsherbiny ME et al. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. 2013 Prog. Lipid Res. pmid:23981365
Wang Y et al. DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. 2013 Biomed Res Int pmid:23984342
Chien KL et al. Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort. 2013 Atherosclerosis pmid:23958266
Hashimoto M et al. Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2013 Neurochem. Res. pmid:23963508
Tabbaa M et al. Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. 2013 Nutrients pmid:23966110
van der Merwe LF et al. Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. 2013 Am. J. Clin. Nutr. pmid:23221579
Betancor MB et al. Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23202658
Crawford MA et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23206328
Kim K et al. A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. 2013 Bioresour. Technol. pmid:23206808
Das UN Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. 2013 Nutrition pmid:23911220
Köhnke T et al. Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. 2013 Biomed Res Int pmid:24083240
Lluís L et al. Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. 2013 Lipids Health Dis pmid:24083393
Valentine CJ et al. Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors. 2013 Breastfeed Med pmid:22568471
Wu BT et al. Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. 2013 Br. J. Nutr. pmid:22691303
Flock MR et al. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. 2013 J Am Heart Assoc pmid:24252845
Nikolakopoulou Z et al. Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. 2013 Carcinogenesis pmid:23892603
D'Souza V et al. Counteracting oxidative stress in pregnancy through modulation of maternal micronutrients and omega-3 fatty acids. 2013 Curr. Med. Chem. pmid:24274816
Tomita T et al. High concentrations of omega-3 fatty acids are associated with the development of atrial fibrillation in the Japanese population. 2013 Heart Vessels pmid:22696184
Makrides M DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22698951
Sofi F et al. The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. 2013 Asia Pac J Clin Nutr pmid:23353608
McEwen BJ et al. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. 2013 Semin. Thromb. Hemost. pmid:23329646
Turk HF et al. Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. 2013 Am. J. Physiol., Cell Physiol. pmid:23426968
Sun SN et al. Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. 2013 Int J Clin Exp Pathol pmid:23330014
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Depner CM et al. Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. 2013 J. Nutr. pmid:23303872
Uhl O et al. Changes of molecular glycerophospholipid species in plasma and red blood cells during docosahexaenoic acid supplementation. 2013 Lipids pmid:24043586
Uusitalo L et al. Fatty acids in serum and diet--a canonical correlation analysis among toddlers. 2013 Matern Child Nutr pmid:22066932
Aliche-Djoudi F et al. A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. 2013 Food Chem. Toxicol. pmid:23907024
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Gupta A et al. Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. 2013 J. Ind. Microbiol. Biotechnol. pmid:23990167
Satkunendrarajah K and Fehlings MG Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. 2013 Exp. Neurol. pmid:23994716
Li Y et al. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. 2013 Immunity pmid:24238341