Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Auestad N et al. | Growth and development in term infants fed long-chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study. | 2001 | Pediatrics | pmid:11483802 |
Pasquier E et al. | Effects of delta5 polyunsaturated fatty acids of maritime pine (Pinus pinaster) seed oil on the fatty acid profile of the developing brain of rats. | 2001 | Lipids | pmid:11485159 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Reich EE et al. | Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. | 2001 | J. Neurosci. | pmid:11487622 |
Voigt RG et al. | A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. | 2001 | J. Pediatr. | pmid:11487742 |
Bradley MO et al. | Tumor targeting by conjugation of DHA to paclitaxel. | 2001 | J Control Release | pmid:11489499 |
Grobas S et al. | Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens. | 2001 | Poult. Sci. | pmid:11495470 |
Su HM et al. | Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. | 2001 | J. Biol. Chem. | pmid:11500517 |
Araya J et al. | Red wine raises plasma HDL and preserves long-chain polyunsaturated fatty acids in rat kidney and erythrocytes. | 2001 | Br. J. Nutr. | pmid:11502232 |
Aidos I et al. | Upgrading of maatjes herring byproducts: production of crude fish oil. | 2001 | J. Agric. Food Chem. | pmid:11513650 |
Reynolds LM et al. | Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. | 2001 | Neurosci. Lett. | pmid:11514074 |
De Nys K et al. | Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. | 2001 | Biochim. Biophys. Acta | pmid:11514237 |
Williard DE et al. | Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes. | 2001 | J. Lipid Res. | pmid:11518755 |
Hoffman DR et al. | Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa. | 2001 | J. Lipid Res. | pmid:11518758 |
Luquain C et al. | High-performance liquid chromatography determination of bis(monoacylglycerol) phosphate and other lysophospholipids. | 2001 | Anal. Biochem. | pmid:11520030 |
Shaikh SR et al. | Formation of inverted hexagonal phase in SDPE as observed by solid-state (31)P NMR. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520062 |
Ando Y and Oomi Y | Positional distribution of highly unsaturated fatty acids in triacyl-sn-glycerols of Artemia nauplii enriched with docosahexaenoic acid ethyl ester. | 2001 | Lipids | pmid:11521972 |
Poisson L and Ergan F | Docosahexaenoic acid ethyl esters from Isochrysis galbana. | 2001 | J. Biotechnol. | pmid:11522364 |
Kuroda Y et al. | Desmutagenic and bio-antimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured Chinese hamster V79 cells. | 2001 | Mutat. Res. | pmid:11525914 |
Ollero M et al. | Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. | 2001 | Hum. Reprod. | pmid:11527898 |
Moya M et al. | Fatty acid absorption in preterms on formulas with and without long-chain polyunsaturated fatty acids and in terms on formulas without these added. | 2001 | Eur J Clin Nutr | pmid:11528489 |
Moore NG et al. | Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells. | 2001 | Breast Cancer Res. Treat. | pmid:11561774 |
Costabile M et al. | A novel long chain polyunsaturated fatty acid, beta-Oxa 21:3n-3, inhibits T lymphocyte proliferation, cytokine production, delayed-type hypersensitivity, and carrageenan-induced paw reaction and selectively targets intracellular signals. | 2001 | J. Immunol. | pmid:11564817 |
Hirafuji M et al. | Inhibition by docosahexaenoic acid of receptor-mediated Ca(2+) influx in rat vascular smooth muscle cells stimulated with 5-hydroxytryptamine. | 2001 | Eur. J. Pharmacol. | pmid:11567649 |
Infante JP et al. | High levels of docosahexaenoic acid (22:6n-3)-containing phospholipids in high-frequency contraction muscles of hummingbirds and rattlesnakes. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11567891 |
Miller RR et al. | Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. | 2001 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11574286 |
Yoshida H et al. | Effect of dietary seal and fish oils on lipid metabolism in hamsters. | 2001 | J. Nutr. Sci. Vitaminol. | pmid:11575580 |
Brand A and Yavin E | Early ethanolamine phospholipid translocation marks stress-induced apoptotic cell death in oligodendroglial cells. | 2001 | J. Neurochem. | pmid:11579130 |
Cha SH et al. | Chronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice. | 2001 | J. Nutr. | pmid:11584083 |
Ozawa I et al. | Purification of docosahexaenoic acid ethyl ester using a silver-ion-immobilized porous hollow-fiber membrane module. | 2001 Sep-Oct | Biotechnol. Prog. | pmid:11587581 |
Ikemoto A et al. | Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. | 2001 | J. Lipid Res. | pmid:11590222 |
Denys A et al. | Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. | 2001 | Lipids | pmid:11592732 |
Rump P and Hornstra G | Relation between arachidonic acid and docosahexaenoic acid in maternal and neonatal blood. | 2001 | Eur J Clin Nutr | pmid:11593355 |
Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
Bradley MO et al. | Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. | 2001 | Clin. Cancer Res. | pmid:11595719 |
Li QC et al. | [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596318 |
Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
Innis SM et al. | Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? | 2001 | J. Pediatr. | pmid:11598600 |
Dewailly E E et al. | Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers. | 2001 | Am. J. Clin. Nutr. | pmid:11684528 |
Politi LE et al. | Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11687549 |
Fan KW et al. | Eicosapentaenoic and docosahexaenoic acids production by and okara-utilizing potential of thraustochytrids. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11687930 |
Lampen A et al. | Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells. | 2001 | Biochim. Biophys. Acta | pmid:11690641 |
Helland IB et al. | Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. | 2001 | Pediatrics | pmid:11694666 |
Wang JY and Saito M | Dietary supplementation of N-3 fatty acids and hydroperoxide levels in rat retinas. | 2001 | Free Radic. Res. | pmid:11697133 |
Roque ME et al. | Effect of surfactants and natural detergents on phosphatidylcholine synthesis in photoreceptor membranes. | 2001 | Membr Cell Biol | pmid:11699863 |
Strandvik B et al. | Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis. | 2001 | J. Pediatr. | pmid:11713441 |
Narayanan BA et al. | Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. | 2001 | Int. J. Oncol. | pmid:11713597 |
Rousseau D et al. | Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats. | 2001 | Mol. Cell. Biochem. | pmid:11716352 |
Jeffrey BG et al. | The role of docosahexaenoic acid in retinal function. | 2001 | Lipids | pmid:11724458 |