Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu Y et al. | Resolvin D1 protects against inflammation in experimental acute pancreatitis and associated lung injury. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26702138 |
Abdulnour RE et al. | Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. | 2016 | Mucosal Immunol | pmid:26647716 |
Crandell JR et al. | Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. | 2016 | Postgrad Med | pmid:27684412 |
Visentin S et al. | Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. | 2016 | Early Hum. Dev. | pmid:27391868 |
Viola JR et al. | Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. | 2016 | Circ. Res. | pmid:27531933 |
Zhang MJ et al. | Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. | 2016 | Circulation | pmid:27507404 |
Inoue Y et al. | Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. | 2016 | Crit. Care Med. | pmid:26509319 |
McManus S et al. | Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men. | 2016 | J. Lipid Res. | pmid:27170732 |
Lu Y et al. | Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. | 2016 | Biosens Bioelectron | pmid:26710343 |
Subbaiah PV et al. | Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. | 2016 | Biochim. Biophys. Acta | pmid:27178174 |
Gold DR et al. | Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. | 2016 | Contemp Clin Trials | pmid:26784651 |
Bassuk SS et al. | Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). | 2016 | Contemp Clin Trials | pmid:26767629 |
Gao J et al. | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. | 2016 | Int. J. Dev. Neurosci. | pmid:26639559 |
Si TL et al. | Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation. | 2016 | Mol Med Rep | pmid:27176922 |
Primdahl KG et al. | Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. | 2016 | J. Nat. Prod. | pmid:27704804 |
Jeyanathan J et al. | Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. | 2016 | BMC Microbiol. | pmid:27283157 |
Meesawatsom P et al. | Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. | 2016 | J Neuroinflammation | pmid:27589850 |
Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Heskey CE et al. | Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. | 2016 | Am. J. Clin. Nutr. | pmid:26912497 |
Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
Revuelta M et al. | Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. | 2016 | Brain Pathol. | pmid:25990815 |
Kuda O et al. | Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. | 2016 | Diabetes | pmid:27313314 |
Easley JT et al. | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. | 2016 | Physiol Rep | pmid:27694530 |
McNamara RK and Welge JA | Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. | 2016 | Bipolar Disord | pmid:27087497 |
Bascoul-Colombo C et al. | Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. | 2016 | Biochim. Biophys. Acta | pmid:26968097 |
Kim KH et al. | Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. | 2016 | Int J Chron Obstruct Pulmon Dis | pmid:27313451 |
Zhao YL et al. | Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis. | 2016 | Chin. Med. J. | pmid:27098797 |
Gharekhani A et al. | Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. | 2016 | Iran J Kidney Dis | pmid:27721230 |
Schmid M et al. | Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. | 2016 | J. Immunol. | pmid:26969756 |
Lehmann C et al. | Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. | 2015 | FASEB J. | pmid:26289316 |
Taylan A et al. | S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. | 2015 | J. Korean Med. Sci. | pmid:26339162 |
Pierdomenico AM et al. | MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. | 2015 | J. Biol. Chem. | pmid:25505240 |
Saito H et al. | Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. | 2015 | J Oleo Sci | pmid:26028326 |
Calandria JM et al. | The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. | 2015 | Cell. Mol. Neurobiol. | pmid:26047923 |
Suo R et al. | Generation of Tetracosahexaenoic Acid in Benthic Marine Organisms. | 2015 | J Oleo Sci | pmid:26136172 |
Park CK | Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. | 2015 | Mediators Inflamm. | pmid:26617436 |
Kotani K et al. | Enzymatic preparation of human milk fat substitutes and their oxidation stability. | 2015 | J Oleo Sci | pmid:25757431 |
Fischer T | [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. | 2015 | Orv Hetil | pmid:26548469 |
Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
Norris SE et al. | Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. | 2015 | Neurobiol. Aging | pmid:25676385 |
Talvas J et al. | Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. | 2015 | Clin Nutr | pmid:25575640 |
Wendell SG et al. | 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. | 2015 | J. Biol. Chem. | pmid:25586183 |
Harrison JL et al. | Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. | 2015 | Brain Behav. Immun. | pmid:25585137 |
Ross AB et al. | Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, β-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. | 2015 | J. Nutr. | pmid:26400963 |
Zgorzynska E et al. | Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. | 2015 | Arch. Oral Biol. | pmid:25455128 |
Yang S et al. | Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. | 2015 | J Oleo Sci | pmid:25757428 |
Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |
Esmaeili V et al. | Dietary fatty acids affect semen quality: a review. | 2015 | Andrology | pmid:25951427 |