| MeSH term | MeSH ID | Detail |
|---|---|---|
| Birth Weight | D001724 | 23 associated lipids |
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Periodontitis | D010518 | 22 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Shock | D012769 | 11 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shomonov-Wagner L et al. | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. | 2015 | Lipids Health Dis | pmid:25889505 |
| Lehmann C et al. | Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. | 2015 | FASEB J. | pmid:26289316 |
| Hsiao HM et al. | Resolvin D1 Reduces Emphysema and Chronic Inflammation. | 2015 | Am. J. Pathol. | pmid:26468975 |
| Taylan A et al. | S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. | 2015 | J. Korean Med. Sci. | pmid:26339162 |
| Cox R et al. | Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25647402 |
| Pierdomenico AM et al. | MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. | 2015 | J. Biol. Chem. | pmid:25505240 |
| Saito H et al. | Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. | 2015 | J Oleo Sci | pmid:26028326 |
| Suo R et al. | Generation of Tetracosahexaenoic Acid in Benthic Marine Organisms. | 2015 | J Oleo Sci | pmid:26136172 |
| Kanan Y et al. | Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. | 2015 | Cell. Mol. Neurobiol. | pmid:25212825 |
| Serhan CN et al. | Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. | 2015 | Biochim. Biophys. Acta | pmid:25139562 |
| Wang CW et al. | Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. | 2015 | Infect. Immun. | pmid:26667839 |
| Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
| Kotani K et al. | Enzymatic preparation of human milk fat substitutes and their oxidation stability. | 2015 | J Oleo Sci | pmid:25757431 |
| Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
| Fischer T | [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. | 2015 | Orv Hetil | pmid:26548469 |
| Wang Y et al. | Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. | 2015 | ACS Appl Mater Interfaces | pmid:26539742 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Ercan S et al. | Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. | 2015 | Lipids Health Dis | pmid:25889219 |
| Talvas J et al. | Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. | 2015 | Clin Nutr | pmid:25575640 |
| Wendell SG et al. | 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. | 2015 | J. Biol. Chem. | pmid:25586183 |
| Maciejewska D et al. | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. | 2015 | World J. Gastroenterol. | pmid:25574105 |
| Morin C et al. | Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. | 2015 | Arthritis Res. Ther. | pmid:26022389 |
| Yoshinaga K et al. | Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. | 2015 | J. Nutr. Biochem. | pmid:25448607 |
| Cheatham CL and Sheppard KW | Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. | 2015 | Nutrients | pmid:26540073 |
| Harrison JL et al. | Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. | 2015 | Brain Behav. Immun. | pmid:25585137 |
| Brigandi SA et al. | Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. | 2015 | Int J Mol Sci | pmid:25946342 |
| Ross AB et al. | Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, β-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. | 2015 | J. Nutr. | pmid:26400963 |
| Ossani GP et al. | Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. | 2015 | J Oleo Sci | pmid:25948137 |
| Zgorzynska E et al. | Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. | 2015 | Arch. Oral Biol. | pmid:25455128 |
| Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
| Wang Y et al. | Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. | 2015 | Shock | pmid:26196843 |
| Yang S et al. | Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. | 2015 | J Oleo Sci | pmid:25757428 |
| Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
| Wijendran V et al. | Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. | 2015 | Pediatr. Res. | pmid:26270575 |
| Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |
| Esmaeili V et al. | Dietary fatty acids affect semen quality: a review. | 2015 | Andrology | pmid:25951427 |
| Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
| Akimov MG et al. | [The influence of docosahexaenoic acid moiety on cytotoxic activity of 1,2,4-thiadiazole derivatives]. | 2014 Jul-Aug | Biomed Khim | pmid:25249531 |
| Kar S | Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. | 2014 Jan-Feb | Am J Ther | pmid:21975796 |
| Casanova E et al. | Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. | 2014 Jan-Feb | Biofactors | pmid:23983179 |
| Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
| Lee EJ et al. | Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. | 2014 | Biochim. Biophys. Acta | pmid:24120917 |
| Betsholtz C | Physiology: Double function at the blood-brain barrier. | 2014 | Nature | pmid:24828036 |
| Nguyen LN et al. | Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. | 2014 | Nature | pmid:24828044 |
| Chua A et al. | Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. | 2014 | Environ. Mol. Mutagen. | pmid:24828973 |
| Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
| Buckley CD et al. | Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. | 2014 | Immunity | pmid:24656045 |
| Cui ZG et al. | Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. | 2014 | Chem. Biol. Interact. | pmid:24661947 |
| Murali G et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24332315 |
| Chen F et al. | Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. | 2014 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:24072678 |