| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fibrosis | D005355 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Periodontitis | D010518 | 22 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Codde JP et al. | The effect of dietary fish oil and salt on blood pressure and eicosanoid metabolism of spontaneously hypertensive rats. | 1987 | J. Hypertens. | pmid:3611764 |
| Koletzko B | Omega-3 fatty acid requirement. | 1987 | Am. J. Clin. Nutr. | pmid:3039827 |
| Mitchell EA et al. | Clinical characteristics and serum essential fatty acid levels in hyperactive children. | 1987 | Clin Pediatr (Phila) | pmid:2439249 |
| Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
| Bjørneboe A et al. | Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. | 1987 | Br. J. Dermatol. | pmid:2823859 |
| Virkkunen ME et al. | Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. | 1987 | Biol. Psychiatry | pmid:2958095 |
| Licensed fish-oil concentrate versus cod-liver oil. | 1987 | Lancet | pmid:2887752 | |
| Jones RG and Henderson MJ | Fish oils as medicines. | 1987 | Lancet | pmid:2887931 |
| Scott BL et al. | Docosahexaenoate metabolism and fatty-acid composition in developing retinas of normal and rd mutant mice. | 1987 | Exp. Eye Res. | pmid:2951268 |
| Anderson RE et al. | Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa. | 1987 | Exp. Eye Res. | pmid:2951269 |
| Hadjiagapiou C and Spector AA | Docosahexaenoic acid metabolism and effect on prostacyclin production in endothelial cells. | 1987 | Arch. Biochem. Biophys. | pmid:2949698 |
| Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
| Ojima A et al. | Selective transacylation of 1-O-alkylglycerophosphoethanolamine by docosahexaenoate and arachidonate in rat brain microsomes. | 1987 | J. Neurochem. | pmid:2951496 |
| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Infante JP | Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport. | 1987 | Mol. Cell. Biochem. | pmid:2955214 |
| Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
| Codde JP et al. | Effects of fish oil "Max EPA" on blood pressures and prostanoid metabolism of spontaneously hypertensive rats during salt loading. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960180 |
| Kobayashi S et al. | Changes of hemorrheological properties by highly purified DHA in normal subjects. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960200 |
| Organisciak DT et al. | Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. | 1987 | Prog. Clin. Biol. Res. | pmid:2960984 |
| Rotstein NP and Aveldaño MI | Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)) docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958089 |
| Rotstein NP and Aveldaño MI | Labeling of phosphatidylcholines of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)), docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958090 |
| Frank H et al. | Fatty acids in liver microsomal lipids of rats exposed to hypoxia, tetrachloromethane, or both. | 1987 | Biochim. Biophys. Acta | pmid:2959325 |
| Urakaze M et al. | Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits. | 1987 | Am. J. Clin. Nutr. | pmid:2825504 |
| von Schacky C | Prophylaxis of atherosclerosis with marine omega-3 fatty acids. A comprehensive strategy. | 1987 | Ann. Intern. Med. | pmid:2825573 |
| Zijlstra JG et al. | Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin-sensitive and -resistant small-cell lung cancer cell lines, and on cytotoxicity in the tumor cell lines. | 1987 | Int. J. Cancer | pmid:2826341 |
| Lokesh BR and Kinsella JE | Modulation of prostaglandin synthesis in mouse peritoneal macrophages by enrichment of lipids with either eicosapentaenoic or docosahexaenoic acids in vitro. | 1987 | Immunobiology | pmid:2828226 |
| Mori TA et al. | New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation. | 1987 | Lipids | pmid:2828811 |
| Fischer S et al. | Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. | 1987 | Prostaglandins | pmid:2829279 |
| van Acker BA et al. | The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients. | 1987 | Nephrol. Dial. Transplant. | pmid:2831474 |
| Fish oil for the heart. | 1987 | Med Lett Drugs Ther | pmid:3025574 | |
| Chamberlain JG and Belton C | Effects of long term consumption of fish oil (Maxepa) on serum lipids and arterial ultrastructure in Japanese quail (Coturnix coturnix japonica). | 1987 | Atherosclerosis | pmid:3689486 |
| Maurice PD et al. | The effects of dietary supplementation with fish oil in patients with psoriasis. | 1987 | Br. J. Dermatol. | pmid:3689678 |
| Thiery J and Seidel D | Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3827970 |
| Sanders TA | Re: Fish oil feeding results in enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3675708 |
| Karmali RA et al. | The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor. | 1987 Nov-Dec | Anticancer Res. | pmid:2831791 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Mehta JL et al. | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. | 1988 | Am. J. Med. | pmid:3276185 |
| Glauber H et al. | Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. | 1988 | Ann. Intern. Med. | pmid:3282462 |
| Blachier F et al. | Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis. | 1988 | Prostaglandins | pmid:2834771 |
| Nielsen M et al. | [3H]diazepam specific binding to rat cortex in vitro is enhanced by oleic, arachidonic and docosahexenoic acid isolated from pig brain. | 1988 | Eur. J. Pharmacol. | pmid:2836212 |
| Garg ML et al. | Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. | 1988 | J. Nutr. | pmid:2836574 |
| Goodnight SH | Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. | 1988 | Semin. Thromb. Hemost. | pmid:2845585 |
| Garg ML et al. | Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. | 1988 | Biochim. Biophys. Acta | pmid:2844278 |
| Lawson LD and Hughes BG | Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847723 |
| Wong SH and Marsh JB | Inhibition of apolipoprotein secretion and phosphatidate phosphohydrolase activity by eicosapentaenoic and docosahexaenoic acids in the perfused rat liver. | 1988 | Metab. Clin. Exp. | pmid:2848178 |
| Shimokawa H et al. | Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig. | 1988 | Br. J. Pharmacol. | pmid:2851360 |
| Mehta J et al. | Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake. | 1988 | Am. Heart J. | pmid:3142242 |
| Huang WH et al. | Control of the sodium pump by liponucleotides and unsaturated fatty acids: side-dependent effects in red cells. | 1988 | Prog. Clin. Biol. Res. | pmid:2851818 |
| Kremer JM | Omega-3 fatty acids in rheumatoid arthritis. | 1988 | Del Med J | pmid:2852607 |
| Luley C et al. | [Fatty acid composition and degree of peroxidation in fish oil and cod liver oil preparations]. | 1988 | Arzneimittelforschung | pmid:2854466 |
| Bittiner SB et al. | A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. | 1988 | Lancet | pmid:2893189 |
| Tobin A | Fish oil supplementation. | 1988 | Lancet | pmid:2896884 |
| Palmblad J and Gyllenhammar H | Effect of dietary lipids on immunity and inflammation. Review article. | 1988 | APMIS | pmid:2841953 |
| Garg ML et al. | Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. | 1988 | Biochim. Biophys. Acta | pmid:2901857 |
| Croset M et al. | Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. | 1988 | Biochem. Pharmacol. | pmid:2965590 |
| Ansari KA and Shoeman D | Rapid separation of free fatty acids from neutral lipids in brain extracts. | 1988 | J. Chromatogr. | pmid:2969915 |
| Hruby K | [Is retinitis pigmentosa absolutely incurable?]. | 1988 | Klin Monbl Augenheilkd | pmid:2969995 |
| Tesoriere L et al. | Modulation by docosahexaenoic acid of the epinephrine-stimulated adenylate cyclase activity of the bovine retina. | 1988 | J. Neurochem. | pmid:2970525 |
| Shingu T et al. | Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). | 1988 | Adv Alcohol Subst Abuse | pmid:2975919 |
| Louie K et al. | Docosahexaenoate-containing molecular species of glycerophospholipids from frog retinal rod outer segments show different rates of biosynthesis and turnover. | 1988 | Biochemistry | pmid:2976602 |
| Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
| Takahashi R et al. | Plasma, platelet, and aorta fatty acids composition in response to dietary n-6 and n-3 fats supplementation in a rat model of non-insulin-dependent diabetes. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:2976815 |
| Karanian JW et al. | Smooth muscle effects of hydroxylated docosahexaenoates produced from human platelet. | 1988 | Biomed. Biochim. Acta | pmid:2977725 |
| Weissmann G et al. | Stimulus-response coupling in marine sponge cell aggregation: lipid metabolism and the function of exogenously added arachidonic and docosahexaenoic acids. | 1988 | Biochim. Biophys. Acta | pmid:2968121 |
| Lokesh BR et al. | Differential effects of docosahexaenoic acid and eicosapentaenoic acid on suppression of lipoxygenase pathway in peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:2825816 |
| Covens AL et al. | The effect of dietary supplementation with fish oil fatty acids on surgically induced endometriosis in the rabbit. | 1988 | Fertil. Steril. | pmid:2832216 |
| Ackman RG | Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. | 1988 | Atherosclerosis | pmid:2833284 |
| Ferretti A et al. | Occurrence of prostaglandin E3 in human urine as a result of marine oil ingestion: gas chromatographic-mass spectrometric evidence. | 1988 | Biochim. Biophys. Acta | pmid:3162687 |
| Maxepa--Eskimos, fish oils and ischaemic heart disease. | 1988 | Drug Ther Bull | pmid:3053081 | |
| Schmidt EB et al. | The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris. | 1988 | Artery | pmid:3178506 |
| Zucker ML et al. | Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. | 1988 | Atherosclerosis | pmid:3178928 |
| Miller JP et al. | Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study. | 1988 | Clin. Chim. Acta | pmid:3071435 |
| Croset M et al. | Different metabolic behavior of long-chain n-3 polyunsaturated fatty acids in human platelets. | 1988 | Biochim. Biophys. Acta | pmid:2839237 |
| Hörcher U | [Omega-3-fatty acids from fish oil for the prevention of myocardial infarct]. | 1988 | Pharm Unserer Zeit | pmid:2840674 |
| Ishiguro J et al. | [Effects of ethyl eicosapentaenoate (EPA-E) and its metabolite on the drug and fatty acid metabolizing enzyme systems in rat liver]. | 1988 | Yakugaku Zasshi | pmid:2841446 |
| Cardiovascular effects of n-3 fatty acids. | 1988 | N. Engl. J. Med. | pmid:2841599 | |
| Hatmi M et al. | Interference of eicosapentaenoic and docosahexaenoic acids with arachidonate-and U46619-induced platelet activation and desensitization. | 1988 | Biochem. Pharmacol. | pmid:2827688 |
| Whittle JC | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. | 1988 | Am. J. Med. | pmid:3376983 |
| Gibney MJ and Bolton-Smith C | The effect of a dietary supplement of n-3 polyunsaturated fat on platelet lipid composition, platelet function and platelet plasma membrane fluidity in healthy volunteers. | 1988 | Br. J. Nutr. | pmid:3408705 |
| Cahill PD et al. | Inhibition of vein graft intimal thickening by eicosapentanoic acid: reduced thromboxane production without change in lipoprotein levels or low-density lipoprotein receptor density. | 1988 | J. Vasc. Surg. | pmid:3336117 |
| Vandongen R et al. | Hypercholesterolaemic effect of fish oil in insulin-dependent diabetic patients. | 1988 | Med. J. Aust. | pmid:3340028 |
| Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Demke DM et al. | Effects of a fish oil concentrate in patients with hypercholesterolemia. | 1988 | Atherosclerosis | pmid:3355619 |
| Goodnight SH | The effects of omega-3 fatty acids on thrombosis and atherogenesis. | 1989 | Hematol Pathol | pmid:2545665 |
| Lee TH and Arm JP | The effects of a fish oil enriched diet on experimentally-induced and clinical asthma. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546399 |
| Hirai A et al. | Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546401 |
| Schaffer HK | Essential fatty acids and eicosanoids in cutaneous inflammation. | 1989 | Int. J. Dermatol. | pmid:2546896 |
| Steiner A et al. | Effect of fish oil on blood pressure and serum lipids in hypertension and hyperlipidaemia. | 1989 | J Hypertens Suppl | pmid:2547916 |
| Sanders TA et al. | Influence of n-3 fatty acids on blood lipids in normal subjects. | 1989 | J Intern Med Suppl | pmid:2539838 |
| Bates D et al. | A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis. | 1989 | J. Neurol. Neurosurg. Psychiatr. | pmid:2540285 |
| Kim HY and Salem N | Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. | 1989 | Prostaglandins | pmid:2541468 |
| Burns CP et al. | Effect of docosahexaenoic acid on rate of differentiation of HL-60 human leukemia. | 1989 | Cancer Res. | pmid:2541901 |
| Westberg G et al. | Effect of eicosapentaenoic acid rich menhaden oil and MaxEPA on the autoimmune disease of Mrl/l mice. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2542168 |
| Chernenko GA et al. | Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2742878 |
| Bandyopadhyay GK et al. | Docosahexaenoic acid is neither synthesized nor retroconverted by the normal and tumor mouse mammary epithelial cells in primary culture. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2522001 |
| Wetzel MG et al. | Metabolic labeling of normal canine rod outer segment phospholipids in vivo and in vitro. | 1989 | Exp. Eye Res. | pmid:2522054 |
| Scott BL and Bazan NG | Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2523075 |
| VanRollins M et al. | Synthesis of epoxide and vicinal diol regioisomers from docosahexaenoate methyl esters. | 1989 | J. Lipid Res. | pmid:2523946 |
| Clark WF et al. | Omega-3 fatty acid dietary supplementation in systemic lupus erythematosus. | 1989 | Kidney Int. | pmid:2811063 |