Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Goustard-Langelier B et al. | Phospholipid incorporation and metabolic conversion of n-3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line. | 2000 | J. Neurosci. Res. | pmid:10820439 |
Weber P and Raederstorff D | Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review. | 2000 | Nutr Metab Cardiovasc Dis | pmid:10812585 |
Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
Valk EE and Hornstra G | Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. | 2000 | Int J Vitam Nutr Res | pmid:10804454 |
Amamoto T et al. | [Relationship between hippocampal arachidonic acid content and induction of LTP in aged rats]. | 1999 | Nihon Shinkei Seishin Yakurigaku Zasshi | pmid:10803212 |
Yano M et al. | Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. | 2000 | J. Nutr. | pmid:10801904 |
Itokazu N et al. | Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. | 2000 | Brain Res. | pmid:10799687 |
Tsukada H et al. | Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys. | 2000 | Brain Res. | pmid:10799683 |
Smit EN et al. | Fish oil supplementation improves docosahexaenoic acid status of malnourished infants. | 2000 | Arch. Dis. Child. | pmid:10799425 |
Mori TA et al. | Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. | 2000 | Am. J. Clin. Nutr. | pmid:10799369 |
Bechoua S et al. | Protective effect of docosahexaenoic acid against hydrogen peroxide-induced oxidative stress in human lymphocytes. | 1999 | Biochem. Pharmacol. | pmid:10796072 |
Greatrex JC et al. | Scotopic sensitivity in dyslexia and requirements for DHA supplementation. | 2000 | Lancet | pmid:10791530 |
Meluzzi A et al. | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. | 2000 | Poult. Sci. | pmid:10780651 |
MartÃnez M et al. | [Treatment of generalized peroxisomal disorders with docosahexaenoic acid ethyl ether]. | 1999 | Rev Neurol | pmid:10778491 |
Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
Onuki Y et al. | In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption. | 2000 | Int J Pharm | pmid:10767564 |
Xi S et al. | Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765974 |
Ogilvie GK et al. | Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. | 2000 | Cancer | pmid:10760770 |
Kim HY and Hamilton J | Accumulation of docosahexaenoic acid in phosphatidylserine is selectively inhibited by chronic ethanol exposure in C-6 glioma cells. | 2000 | Lipids | pmid:10757550 |
Gaposchkin DP et al. | Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. | 2000 | Lipids | pmid:10757549 |
Conquer JA et al. | Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. | 2000 | Lipids | pmid:10757545 |
Gross EA et al. | G239T mutation in Repeat 1 of human IRBP: possible implications for more than one binding site in a single repeat. | 2000 | Mol. Vis. | pmid:10756181 |
Birch EE et al. | A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. | 2000 | Dev Med Child Neurol | pmid:10755457 |
Sametz W et al. | Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). | 2000 | Pharmacology | pmid:10754452 |
Igarashi M and Miyazawa T | Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753678 |
Puri BK et al. | Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. | 2000 Jan-Feb | Int. J. Clin. Pract. | pmid:10750263 |
Brooks SL et al. | Mothers, infants, and DHA. Implications for nursing practice. | 2000 Mar-Apr | MCN Am J Matern Child Nurs | pmid:10748583 |
Surai PF et al. | Designer egg evaluation in a controlled trial. | 2000 | Eur J Clin Nutr | pmid:10745280 |
Thakkar RR et al. | Docosahexaenoic acid reverses cyclosporin A-induced changes in membrane structure and function. | 2000 | Biochim. Biophys. Acta | pmid:10742598 |
Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
Grande JP et al. | Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo. | 2000 | Kidney Int. | pmid:10720955 |
Hempenius RA et al. | Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats. | 2000 Feb-Mar | Food Chem. Toxicol. | pmid:10717353 |
Hansen J et al. | Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. | 2000 | Thromb. Res. | pmid:10713313 |
Yasuda S et al. | Dietary docosahexaenoic acid enhances ferric nitrilotriacetate-induced oxidative damage in mice but not when additional alpha-tocopherol is supplemented. | 1999 | Free Radic. Res. | pmid:10711790 |
Madsen L et al. | EPA and DHA possess different metabolic properties. | 1999 | Adv. Exp. Med. Biol. | pmid:10709658 |
Berge K et al. | Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture. | 1999 | Adv. Exp. Med. Biol. | pmid:10709646 |
Berge RK et al. | Hypolipidemic 3-thia fatty acids. Fatty acid oxidation and ketogenesis in rat liver under proliferation of mitochondria and peroxisomes. | 1999 | Adv. Exp. Med. Biol. | pmid:10709636 |
Yamashita K et al. | Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. | 2000 | Biofactors | pmid:10705949 |
Wang L et al. | Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women. | 2000 | Pediatr Int | pmid:10703228 |
Volker DH et al. | The eicosapentaenoic to docosahexaenoic acid ratio of diets affects the pathogenesis of arthritis in Lew/SSN rats. | 2000 | J. Nutr. | pmid:10702585 |
Negretti N et al. | Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. | 2000 | J. Physiol. (Lond.) | pmid:10699081 |
Cunnane SC et al. | Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. | 2000 | Lipids | pmid:10695931 |
Baur LA et al. | Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding. | 2000 | Lipids | pmid:10695927 |
Tomobe YI et al. | Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. | 2000 | Lipids | pmid:10695925 |
Ghebremeskel K et al. | Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood. | 2000 | Eur J Clin Nutr | pmid:10694772 |
Reich EE et al. | Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. | 2000 | Biochemistry | pmid:10694406 |
Zuijdgeest-van Leeuwen SD et al. | Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions. | 1999 | Br. J. Nutr. | pmid:10690163 |
Watanabe T and Kuroda Y | The effect of a newly developed ointment containing eicosapentaenoic acid and docosahexaenoic acid in the treatment of atopic dermatitis. | 1999 | J. Med. Invest. | pmid:10687312 |
Arterburn LM et al. | A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO oil). | 2000 | Food Chem. Toxicol. | pmid:10685012 |
Sawazaki S et al. | The effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled study. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10683816 |
Infante JP and Huszagh VA | Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. | 2000 | FEBS Lett. | pmid:10683429 |
Bonin A and Khan NA | Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels. | 2000 | J. Lipid Res. | pmid:10681412 |
Calviello G et al. | n-3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice. | 2000 | J. Lipid Res. | pmid:10681400 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Engler MM et al. | The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670690 |
Stillwell W et al. | Detection of lipid domains in docasahexaenoic acid-rich bilayers by acyl chain-specific FRET probes. | 2000 | Chem. Phys. Lipids | pmid:10669305 |
Morrow JD et al. | Formation of novel isoprostane-like compounds from docosahexaenoic acid. | 1999 | Adv. Exp. Med. Biol. | pmid:10667351 |
Moore SA et al. | Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines. | 1999 | Adv. Exp. Med. Biol. | pmid:10667320 |
Shikano M et al. | Inhibition of protein tyrosine kinase activity by 1a-docosahexaenoyl mitomycin C. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667236 |
Calabresi L et al. | Omacor in familial combined hyperlipidemia: effects on lipids and low density lipoprotein subclasses. | 2000 | Atherosclerosis | pmid:10657575 |
Ollero M et al. | Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: implications for sperm lipoperoxidative damage. | 2000 | Mol. Reprod. Dev. | pmid:10657052 |
Cunnane SC and Francescutti V | Fatty acid profiles of maternal adipose tissue in relation to infant development. | 1999 | Br. J. Nutr. | pmid:10655972 |
Wensing AG et al. | Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. | 1999 | Br. J. Nutr. | pmid:10655965 |
Cunnane S | Modelling human infant requirements for long-chain polyunsaturated fatty acids. | 1999 | Br. J. Nutr. | pmid:10655962 |
Lapillonne A et al. | Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months. | 2000 Jan-Feb | Eur. J. Pediatr. | pmid:10653329 |
Janssen A et al. | Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. | 2000 | Lab. Invest. | pmid:10653000 |
Polette A et al. | Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. | 1999 | Lipids | pmid:10652994 |
Devlin AM and Innis SM | Dietary phospholipid alters biliary lipid composition in formula-fed piglets. | 1999 | Lipids | pmid:10652991 |
Hashimoto M et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. | 1999 | Lipids | pmid:10652989 |
Greener M | Fatty acid imbalance might lead to novel treatments for CF. | 2000 | Mol Med Today | pmid:10652475 |
Diep QN et al. | Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. | 2000 | Hypertension | pmid:10642312 |
Connolly JM et al. | Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. | 1999 | Nutr Cancer | pmid:10624705 |
Lucas A et al. | Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomised trial. | 1999 | Lancet | pmid:10622297 |
Gibson RA | Long-chain polyunsaturated fatty acids and infant development. | 1999 | Lancet | pmid:10622289 |
MartÃnez M et al. | Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. | 2000 | Am. J. Clin. Nutr. | pmid:10618001 |
Donadio JV | Use of fish oil to treat patients with immunoglobulin a nephropathy. | 2000 | Am. J. Clin. Nutr. | pmid:10618000 |
Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
Hughes DA and Pinder AC | n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. | 2000 | Am. J. Clin. Nutr. | pmid:10617997 |
Kremer JM | n-3 fatty acid supplements in rheumatoid arthritis. | 2000 | Am. J. Clin. Nutr. | pmid:10617995 |
James MJ et al. | Dietary polyunsaturated fatty acids and inflammatory mediator production. | 2000 | Am. J. Clin. Nutr. | pmid:10617994 |
Burgess JR et al. | Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. | 2000 | Am. J. Clin. Nutr. | pmid:10617991 |
Stordy BJ | Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. | 2000 | Am. J. Clin. Nutr. | pmid:10617990 |
Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
Auestad N and Innis SM | Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10617988 |
Makrides M and Gibson RA | Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation. | 2000 | Am. J. Clin. Nutr. | pmid:10617987 |
Jensen CL et al. | Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. | 2000 | Am. J. Clin. Nutr. | pmid:10617985 |
Al MD et al. | Long-chain polyunsaturated fatty acids, pregnancy, and pregnancy outcome. | 2000 | Am. J. Clin. Nutr. | pmid:10617984 |
Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
Carlson SE | Behavioral methods used in the study of long-chain polyunsaturated fatty acid nutrition in primate infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617982 |
Neuringer M | Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications. | 2000 | Am. J. Clin. Nutr. | pmid:10617981 |
Innis SM | Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. | 2000 | Am. J. Clin. Nutr. | pmid:10617978 |
Connor WE | Importance of n-3 fatty acids in health and disease. | 2000 | Am. J. Clin. Nutr. | pmid:10617967 |
Connor SL et al. | Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. | 2000 | Am. J. Clin. Nutr. | pmid:10617942 |
Tolley EA and Carlson SE | Considerations of statistical power in infant studies of visual acuity development and docosahexaenoic acid status. | 2000 | Am. J. Clin. Nutr. | pmid:10617938 |
Makrides M et al. | A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. | 2000 | Pediatrics | pmid:10617701 |
Ghebremeskel K et al. | Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. | 1999 | Br. J. Nutr. | pmid:10615212 |
McGahon BM et al. | Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. | 1999 | Neuroscience | pmid:10613520 |
Nitsan Z et al. | Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. | 1999 | J. Agric. Food Chem. | pmid:10606584 |
Retterstøl K et al. | The pathway from arachidonic to docosapentaenoic acid (20:4n-6 to 22:5n-6) and from eicosapentaenoic to docosahexaenoic acid (20:5n-3 to 22:6n-3) studied in testicular cells from immature rats. | 2000 | Biochim. Biophys. Acta | pmid:10601701 |
Miyazaki M et al. | Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. | 2000 | Biochim. Biophys. Acta | pmid:10601699 |