DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van de Lagemaat M et al. | Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21995887 |
| Yi SH et al. | A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22000478 |
| Williard DE et al. | Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324227 |
| Yoshino S and Ellis EF | Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550967 |
| Martin RE et al. | Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324228 |
| Bégin ME et al. | Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550969 |
| Smithers LG et al. | Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20417081 |
| Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
| Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
| Gow RV et al. | Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19230637 |
| Dijck-Brouwer DA et al. | Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589396 |
| Lapillonne A and Jensen CL | Reevaluation of the DHA requirement for the premature infant. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19577914 |
| Pakala R et al. | Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328332 |
| Graf BA et al. | Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20580213 |
| Brenna JT and Salem N | Workshop proceedings: DHA as a required nutrient. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19604681 |
| Shinto L et al. | Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19171471 |
| Yavin E | Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16839753 |
| Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
| Peltier S et al. | Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083359 |
| Saldanha LG et al. | Workshop on DHA as a required nutrient: overview. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19643589 |
| Brenna JT and Diau GY | The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18023566 |
| Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
| Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
| Smithers LG et al. | Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951004 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Plourde M et al. | Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036804 |
| Calon F and Cole G | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18037281 |
| Pifferi F et al. | n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18042368 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
| Wittwer J and Hersberger M | The two faces of the 15-lipoxygenase in atherosclerosis. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17869078 |
| Manna S et al. | Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18614344 |
| Puri BK et al. | A 31-phosphorus neurospectroscopy study of omega-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17761409 |
| Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
| Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
| Bjorgvinsdottir L et al. | Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23999253 |
| Qin Q et al. | Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19019647 |
| Chechi K et al. | Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20688254 |
| Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
| Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
| Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
| Van Biervliet S et al. | Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18276127 |
| Matsumoto K et al. | Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8302921 |
| Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |
| Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| van Goor SA et al. | Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19118992 |
| Brown AJ et al. | Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1836062 |
| Bryhn M et al. | The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16806871 |
| Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |