Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gibson RA and Makrides M | The role of long chain polyunsaturated fatty acids (LCPUFA) in neonatal nutrition. | 1998 | Acta Paediatr. | pmid:9825965 |
MartÃnez M and Mougan I | Fatty acid composition of human brain phospholipids during normal development. | 1998 | J. Neurochem. | pmid:9832152 |
Allen PC and Danforth HD | Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. | 1998 | Poult. Sci. | pmid:9835336 |
Helland IB et al. | Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. | 1998 | Eur J Clin Nutr | pmid:9846598 |
Saha SK et al. | Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid. | 1998 | Jpn. J. Physiol. | pmid:9852344 |
Yuan C et al. | The unique lipid composition of gecko (Gekko Gekko) photoreceptor outer segment membranes. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9854823 |
Rotstein NP et al. | Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9856786 |
Martin RE | Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. | 1998 | J. Neurosci. Res. | pmid:9856864 |
Huster D et al. | Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. | 1998 | Biochemistry | pmid:9860844 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
Cho HP et al. | Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. | 1999 | J. Biol. Chem. | pmid:9867867 |
Ward GR et al. | Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats. | 1998 | J. Nutr. | pmid:9868196 |
Ishihara K et al. | Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. | 1998 | Lipids | pmid:9870906 |
Hansen JB et al. | Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. | 1998 | Lipids | pmid:9870908 |
Vaagenes H et al. | Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. | 1998 | Lipids | pmid:9870909 |
Akedo I et al. | Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules. | 1998 | Jpn. J. Clin. Oncol. | pmid:9879296 |
Bernoud N et al. | Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. | 1999 | J. Neurochem. | pmid:9886086 |
Mani I et al. | Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. | 1999 | J. Invest. Dermatol. | pmid:9886262 |
Marzo I et al. | Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888202 |
Kollman KA et al. | Dietary lipids influence intestinal adaptation after massive bowel resection. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:9890467 |