| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Neuroaxonal Dystrophies | D019150 | 3 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Innis SM et al. | Marine and freshwater fish oil varying in arachidonic, eicosapentaenoic and docosahexaenoic acids differ in their effects on organ lipids and fatty acids in growing rats. | 1995 | J. Nutr. | pmid:7666244 |
| Schweich MD et al. | Effect of oxygen concentration on production of ethane and thiobarbituric acid-reactive substances by peroxidizing lung and liver homogenates and formation of ethanol by peroxidizing docosahexaenoic acid preparations under hyperoxic conditions. | 1995 | J Toxicol Environ Health | pmid:7666491 |
| Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
| Mano MT et al. | Fish oils modulate blood pressure and vascular contractility in the rat and vascular contractility in the primate. | 1995 | Blood Press. | pmid:7670652 |
| Hughes DA et al. | N-3 polyunsaturated fatty acids (PUFA) modulate the expression of functionally associated molecules on human monocytes. | 1995 | Biochem. Soc. Trans. | pmid:7672332 |
| Niebylski CD and Salem N | A calorimetric investigation of a series of mixed-chain polyunsaturated phosphatidylcholines: effect of sn-2 chain length and degree of unsaturation. | 1994 | Biophys. J. | pmid:7696478 |
| Chapman GE and Wallace HM | Spermine prevents lipid peroxidation induced by essential fatty acids in human breast cancer cells. | 1994 | Biochem. Soc. Trans. | pmid:7698423 |
| Saito M | Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. | 1994 | Ann. Nutr. Metab. | pmid:7702359 |
| Hamosh M | Long chain polyunsaturated fatty acids in neonatal nutrition. | 1994 | J Am Coll Nutr | pmid:7706584 |
| Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
| Sanjurjo P et al. | Polyunsaturated fatty acid status in patients with phenylketonuria. | 1994 | J. Inherit. Metab. Dis. | pmid:7707693 |
| Hexeberg S et al. | Docosahexaenoic acid induces lipid accumulation in myocardial cells of rats. | 1994 | Scand. J. Clin. Lab. Invest. | pmid:7709170 |
| Maehle L et al. | Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines. | 1995 | Br. J. Cancer | pmid:7710930 |
| Hoffman DR and Birch DG | Docosahexaenoic acid in red blood cells of patients with X-linked retinitis pigmentosa. | 1995 | Invest. Ophthalmol. Vis. Sci. | pmid:7730010 |
| Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
| Araya J et al. | [Effect of a diet supplemented with soybean oil or fish oil on the reversibility of docosahexaenoic acid deficiency (22:6w3) in the brain and erythrocytes of rats]. | 1994 | Arch Latinoam Nutr | pmid:7733788 |
| Nada MA et al. | On the rate-limiting step in the beta-oxidation of polyunsaturated fatty acids in the heart. | 1995 | Biochim. Biophys. Acta | pmid:7734439 |
| Achard F et al. | Interconversions and distinct metabolic fate of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in bovine aortic endothelial cells. | 1995 | Biochim. Biophys. Acta | pmid:7734441 |
| Chirouze V et al. | Red blood cell fatty acid composition in low-birth-weight infants fed either human milk or formula during the first months of life. | 1994 | Acta Paediatr Suppl | pmid:7734796 |
| Innis SM | The 1993 Borden Award Lecture. Fatty acid requirements of the newborn. | 1994 | Can. J. Physiol. Pharmacol. | pmid:7736339 |
| Eritsland J et al. | Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. | 1995 | Thromb. Res. | pmid:7740525 |
| Farquharson J et al. | Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex. | 1995 | Arch. Dis. Child. | pmid:7741563 |
| Decsi T et al. | Essential fatty acids in full term infants fed breast milk or formula. | 1995 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:7743279 |
| Byard RW et al. | Sudden infant death syndrome: effect of breast and formula feeding on frontal cortex and brainstem lipid composition. | 1995 | J Paediatr Child Health | pmid:7748681 |
| Ishinaga M et al. | Daily intakes of fatty acids, sterols, and phospholipids by Japanese women and serum cholesterol. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7751974 |
| Rose DP et al. | Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. | 1995 | J. Natl. Cancer Inst. | pmid:7752256 |
| Al MD et al. | The essential fatty acid status of mother and child in pregnancy-induced hypertension: a prospective longitudinal study. | 1995 | Am. J. Obstet. Gynecol. | pmid:7755079 |
| Onwude JL et al. | A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. | 1995 | Br J Obstet Gynaecol | pmid:7756226 |
| Pawlosky RJ and Salem N | Ethanol exposure causes a decrease in docosahexaenoic acid and an increase in docosapentaenoic acid in feline brains and retinas. | 1995 | Am. J. Clin. Nutr. | pmid:7762532 |
| Lucien FP et al. | Separation of biomolecules using supercritical fluid extraction. | 1993 May-Jun | Australas Biotechnol | pmid:7763846 |
| Li ZY and Ward OP | Production of docosahexaenoic acid by Thraustochytrium roseum. | 1994 | J. Ind. Microbiol. | pmid:7765049 |
| Makrides M et al. | Are long-chain polyunsaturated fatty acids essential nutrients in infancy? | 1995 | Lancet | pmid:7769900 |
| Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
| Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
| Denzlinger C et al. | Modulation of the endogenous leukotriene production by fish oil and vitamin E. | 1995 | J Lipid Mediat Cell Signal | pmid:7780681 |
| Leaf A | Omega-3 fatty acids and prevention of ventricular fibrillation. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784457 |
| Shimizu S et al. | omega-Hydroxylation of docosahexaenoic acid or arachidonic acid in human colonic well differentiated adenocarcinoma homogenate. | 1995 | Biochim. Biophys. Acta | pmid:7786890 |
| Burdge GC and Postle AD | Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. | 1995 | Biochim. Biophys. Acta | pmid:7786898 |
| Jenski LJ et al. | Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine splenocytes. | 1995 | Biochim. Biophys. Acta | pmid:7794954 |
| Zerouga M et al. | Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers. | 1995 | Biochim. Biophys. Acta | pmid:7794965 |
| Kinoshita K et al. | Inhibitory effects of purified eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of murine transplantable mammary tumor. | 1994 May-Jun | In Vivo | pmid:7803721 |
| Mallampalli RK et al. | Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids. | 1994 | Am. J. Physiol. | pmid:7810669 |
| Kim HY et al. | Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. | 1994 | Anal. Chem. | pmid:7810900 |
| Roche H and Gibney MJ | The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. | 1994 | Int J Vitam Nutr Res | pmid:7814240 |
| Khair-el-Din TA et al. | Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro. | 1995 | J. Immunol. | pmid:7822798 |
| Petroni A et al. | Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. | 1994 | Neurochem. Res. | pmid:7824073 |
| Gazzah N et al. | Evidence for brain docosahexaenoate recycling in the free-moving adult rat: implications for measurement of phospholipid synthesis. | 1994 | Neurosci. Lett. | pmid:7824158 |
| Das UN | Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824535 |
| Christensen MS et al. | Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. | 1995 | Am. J. Clin. Nutr. | pmid:7825539 |
| Delton I et al. | Distribution and metabolism of arachidonic and docosahexaenoic acids in rat pineal cells. Effect of norepinephrine. | 1995 | Biochim. Biophys. Acta | pmid:7827119 |