| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Neuroaxonal Dystrophies | D019150 | 3 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| North JA et al. | Cell fatty acid composition affects free radical formation during lipid peroxidation. | 1994 | Am. J. Physiol. | pmid:8048478 |
| Brand MD et al. | Liposomes from mammalian liver mitochondria are more polyunsaturated and leakier to protons than those from reptiles. | 1994 | Comp. Biochem. Physiol. Biochem. Mol. Biol. | pmid:8055185 |
| Reddy S et al. | The influence of maternal vegetarian diet on essential fatty acid status of the newborn. | 1994 | Eur J Clin Nutr | pmid:8055852 |
| Takahashi M et al. | Effect of docosahexaenoic acid on azoxymethane-induced colon carcinogenesis in rats. | 1994 | Cancer Lett. | pmid:8062213 |
| Karanian JW et al. | Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8066103 |
| Sukenik A et al. | Dietary lipids from marine unicellular algae enhance the amount of liver and blood omega-3 fatty acids in rats. | 1994 | Ann. Nutr. Metab. | pmid:8067689 |
| McVeigh GE et al. | Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. | 1994 | Arterioscler. Thromb. | pmid:8068603 |
| Jump DB et al. | Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:8077846 |
| Pyzh MV et al. | [Food supplement containing ω-3 polyunsaturated fatty acids prevents experimental thrombotic occlusion of coronary arteries in dogs]. | 1993 | Kardiologiia | pmid:8084128 |
| Alberghina M et al. | Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat. | 1994 | Neurosci. Lett. | pmid:8084474 |
| Fonlupt P et al. | Incorporation of arachidonic and docosahexaenoic acids into phospholipids of rat brain membranes. | 1994 | Neurosci. Lett. | pmid:8084475 |
| Hanai T et al. | Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. | 1993 | J. Surg. Res. | pmid:8094103 |
| Crawford MA | Aspirin in pregnancy. | 1993 | Lancet | pmid:8095644 |
| Orii T et al. | [Peroxisomal disorders--DNA analysis]. | 1993 | Nippon Rinsho | pmid:8096253 |
| Bourre JM et al. | Dietary alpha-linolenic acid at 1.3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. | 1993 | J. Nutr. | pmid:8100576 |
| Spady DK | Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. | 1993 | J. Lipid Res. | pmid:8105015 |
| Ikai K et al. | Leukotriene A4 hydrolase in human skin. | 1994 | J. Invest. Dermatol. | pmid:8106755 |
| Alvarez RA et al. | Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. | 1994 | Invest. Ophthalmol. Vis. Sci. | pmid:8112987 |
| Wakabayashi S et al. | In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats. | 1994 | J. Cereb. Blood Flow Metab. | pmid:8113326 |
| Somers SD and Erickson KL | Alteration of tumor necrosis factor-alpha production by macrophages from mice fed diets high in eicosapentaenoic and docosahexaenoic fatty acids. | 1994 | Cell. Immunol. | pmid:8118867 |
| Henderson WR et al. | Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects. | 1994 | J. Pediatr. | pmid:8120709 |
| Honoré E et al. | External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8127910 |
| Piatti G et al. | Delaying effects of dietary eicosapentaenoic-docosahexaenoic acids on development of "fatty streaks" in hypercholesterolaemic rabbits. A morphological study by scanning electron microscopy. | 1993 | Drugs Exp Clin Res | pmid:8131713 |
| Hardy SJ et al. | In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids. | 1994 | J. Neurochem. | pmid:8133282 |
| Schjøtt J et al. | Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8140399 |
| Bénistant C et al. | Platelet inhibitory functions of aortic endothelial cells. Effects of eicosapentaenoic and docosahexaenoic acids. | 1993 | Atherosclerosis | pmid:8141848 |
| Shiina T et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. | 1993 | Atherosclerosis | pmid:8141854 |
| Leung FW | Prostaglandins mediate fish oil protection against ethanol-induced gastric mucosal injury in rats. | 1994 | Dig. Dis. Sci. | pmid:8149856 |
| Zhu BQ et al. | Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? | 1994 | Am. Heart J. | pmid:8154411 |
| Rodriguez de Turco EB et al. | Docosahexaenoic acid is taken up by the inner segment of frog photoreceptors leading to an active synthesis of docosahexaenoyl-inositol lipids: similarities in metabolism in vivo and in vitro. | 1994 | Curr. Eye Res. | pmid:8156822 |
| Anderson RE et al. | Plasma lipid changes in PRCD-affected and normal miniature poodles given oral supplements of linseed oil. Indications for the involvement of n-3 fatty acids in inherited retinal degenerations. | 1994 | Exp. Eye Res. | pmid:8157107 |
| Demoz A et al. | Modulation of plasma and hepatic oxidative status and changes in plasma lipid profile by n-3 (EPA and DHA), n-6 (corn oil) and a 3-thia fatty acid in rats. | 1994 | Biochim. Biophys. Acta | pmid:8161562 |
| Ter-Karapetian VA | [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. | 1994 | Voen Med Zh | pmid:8165800 |
| Andersson L et al. | Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. Effect of bile salts. | 1994 | Scand. J. Gastroenterol. | pmid:8171289 |
| Bouziane M et al. | Dietary protein deficiency affects n-3 and n-6 polyunsaturated fatty acids hepatic storage and very low density lipoprotein transport in rats on different diets. | 1994 | Lipids | pmid:8177019 |
| Shikano M et al. | Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl- and alkenylacylglycerophosphoethanolamine. | 1994 | Biochim. Biophys. Acta | pmid:8180247 |
| Calderaro V et al. | Docosahexaenoic acid and signaling pathways in rabbit colon. | 1994 | Mol. Pharmacol. | pmid:8183254 |
| Billman GE et al. | Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8183925 |
| Joulain C et al. | Increased glutathione peroxidase activity in human blood mononuclear cells upon in vitro incubation with n-3 fatty acids. | 1994 | Biochem. Pharmacol. | pmid:8185640 |
| Sawazaki S et al. | Lipoxygenation of docosahexaenoic acid by the rat pineal body. | 1994 | J. Neurochem. | pmid:8189247 |
| Houston L | Dietary change in arthritis. | 1994 | Practitioner | pmid:8208662 |
| Chen Y et al. | Interactions of all-trans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein. | 1993 | Biochemistry | pmid:8218196 |
| Lau CS et al. | Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis--a double-blind placebo controlled study. | 1993 | Br. J. Rheumatol. | pmid:8220938 |
| Chen H and Anderson RE | Metabolism in frog retinal pigment epithelium of docosahexaenoic and arachidonic acids derived from rod outer segment membranes. | 1993 | Exp. Eye Res. | pmid:8224024 |
| Maldjian A et al. | The transfer of docosahexaenoic acid from the yolk to the tissues of the chick embryo. | 1993 | Biochem. Soc. Trans. | pmid:8224445 |
| Fowler KH et al. | Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function. | 1993 | J. Immunol. | pmid:8228217 |
| Kanazawa A and Fujimoto K | Effects of endogenous and exogenous n-3 and n-6 fatty acids on microsomal synthesis of docosahexaenoic acid in vitro. | 1993 | J. Nutr. Sci. Vitaminol. | pmid:8229317 |
| Schmitt Y and Schneider H | [The effect of highly unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology during their administration to patients undergoing chronic hemodialysis treatment]. | 1993 | Z Ernahrungswiss | pmid:8237080 |
| Sumida C et al. | Interaction of unsaturated fatty acids with rat liver glucocorticoid receptors: studies to localize the site of interaction. | 1993 | Acta Endocrinol. | pmid:8237254 |
| Subbaiah PV et al. | Incorporation of dietary n-3 fatty acids into molecular species of phosphatidyl choline and cholesteryl ester in normal human plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8237847 |