| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Neuroaxonal Dystrophies | D019150 | 3 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brouwer IA et al. | Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. | 2002 | Am. J. Cardiol. | pmid:11867059 |
| Birch EE et al. | A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. | 2002 | Am. J. Clin. Nutr. | pmid:11864865 |
| Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
| Qi K et al. | Long-chain polyunsaturated fatty acid accretion in brain. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844978 |
| Takeuchi T et al. | Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. | 2002 | Behav. Brain Res. | pmid:11844586 |
| Marchioli R et al. | Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. | 2001 | Lipids | pmid:11837985 |
| McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
| Bell JG et al. | Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism. | 2002 | J. Nutr. | pmid:11823582 |
| Buznikov GA et al. | [Cholinergic regulation of the sea urchin embryonic and larval development]. | 2001 | Ross Fiziol Zh Im I M Sechenova | pmid:11822358 |
| Qi B et al. | Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. | 2002 | FEBS Lett. | pmid:11801246 |
| Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
| Schiefermeier M and Yavin E | n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain. | 2002 | J. Lipid Res. | pmid:11792731 |
| Whelan J | Targeted taxane therapy for cancer. | 2002 | Drug Discov. Today | pmid:11790612 |
| Neschen S et al. | Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11788372 |
| Gibson RA and Makrides M | Long-chain polyunsaturated fatty acids in breast milk: are they essential? | 2001 | Adv. Exp. Med. Biol. | pmid:11787705 |
| Agostoni C et al. | Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. | 2001 | Adv. Exp. Med. Biol. | pmid:11787675 |
| Huber T et al. | Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. | 2002 | J. Am. Chem. Soc. | pmid:11782182 |
| Pawlosky RJ et al. | Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. | 2001 | Alcohol. Clin. Exp. Res. | pmid:11781509 |
| Valenzuela A and Nieto MS | [Docosahexaenoic acid (DHA) in fetal development and in infant nutrition]. | 2001 | Rev Med Chil | pmid:11775350 |
| Wu FC et al. | Docosahexaenoic acid is superior to eicosapentaenoic acid as the essential fatty acid for growth of grouper, Epinephelus malabaricus. | 2002 | J. Nutr. | pmid:11773511 |
| Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
| Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
| Reich EE et al. | Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Adv. Exp. Med. Biol. | pmid:11764949 |
| de Swaaf ME et al. | Characterisation of extracellular polysaccharides produced by Crypthecodinium cohnii. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11759692 |
| Siddiqui RA et al. | Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. | 2001 | Biochim. Biophys. Acta | pmid:11755213 |
| Noguchi R et al. | Dietary effects of bitter gourd oil on blood and liver lipids of rats. | 2001 | Arch. Biochem. Biophys. | pmid:11747298 |
| Petrache HI et al. | Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy. | 2001 | J. Am. Chem. Soc. | pmid:11741426 |
| Contreras MA et al. | Chronic nutritional deprivation of n-3 alpha-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats. | 2001 | J. Neurochem. | pmid:11739623 |
| Pradalier A et al. | Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. | 2001 | Cephalalgia | pmid:11737007 |
| Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
| Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. | 2001 | J. Lipid Res. | pmid:11734574 |
| Ferdinandusse S et al. | Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. | 2001 | J. Lipid Res. | pmid:11734571 |
| Mizejewski GJ and Pass KA | Fatty acids, alpha-fetoprotein, and cystic fibrosis. | 2001 | Pediatrics | pmid:11731663 |
| Das UN et al. | Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728172 |
| Salem N et al. | Mechanisms of action of docosahexaenoic acid in the nervous system. | 2001 | Lipids | pmid:11724467 |
| Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
| Jeffrey BG et al. | The role of docosahexaenoic acid in retinal function. | 2001 | Lipids | pmid:11724458 |
| Rousseau D et al. | Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats. | 2001 | Mol. Cell. Biochem. | pmid:11716352 |
| Narayanan BA et al. | Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. | 2001 | Int. J. Oncol. | pmid:11713597 |
| Strandvik B et al. | Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis. | 2001 | J. Pediatr. | pmid:11713441 |
| Roque ME et al. | Effect of surfactants and natural detergents on phosphatidylcholine synthesis in photoreceptor membranes. | 2001 | Membr Cell Biol | pmid:11699863 |
| Wang JY and Saito M | Dietary supplementation of N-3 fatty acids and hydroperoxide levels in rat retinas. | 2001 | Free Radic. Res. | pmid:11697133 |
| Helland IB et al. | Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. | 2001 | Pediatrics | pmid:11694666 |
| Lampen A et al. | Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells. | 2001 | Biochim. Biophys. Acta | pmid:11690641 |
| Fan KW et al. | Eicosapentaenoic and docosahexaenoic acids production by and okara-utilizing potential of thraustochytrids. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11687930 |
| Politi LE et al. | Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11687549 |
| Dewailly E E et al. | Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers. | 2001 | Am. J. Clin. Nutr. | pmid:11684528 |
| Innis SM et al. | Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? | 2001 | J. Pediatr. | pmid:11598600 |
| Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
| Li QC et al. | [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596318 |