| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Neuroaxonal Dystrophies | D019150 | 3 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bates EJ et al. | Docosahexanoic acid (22:6, n-3) but not eicosapentaenoic acid (20:5, n-3) can induce neutrophil-mediated injury of cultured endothelial cells: involvement of neutrophil elastase. | 1993 | J. Leukoc. Biol. | pmid:8245712 |
| Reynaud D et al. | Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation. | 1993 | Anal. Biochem. | pmid:8250220 |
| Farquharson J et al. | Effect of diet on infant subcutaneous tissue triglyceride fatty acids. | 1993 | Arch. Dis. Child. | pmid:8257182 |
| Marangoni F et al. | Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DHA) ethyl esters and prolonged washout. | 1993 | Biochim. Biophys. Acta | pmid:8257719 |
| Fowler KH et al. | Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin A-stimulated murine splenocytes. | 1993 | Biochim. Biophys. Acta | pmid:8257724 |
| Richard MJ et al. | Relationship of omega-3 fatty acid supplementation to plasma lipid peroxidation in predialysis patients with hypertriglyceridaemia. | 1993 | Eur J Med | pmid:8257999 |
| Chen H and Anderson RE | Differential incorporation of docosahexaenoic and arachidonic acids in frog retinal pigment epithelium. | 1993 | J. Lipid Res. | pmid:8263418 |
| Ettinger WH et al. | Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. | 1994 | Arterioscler. Thromb. | pmid:8274481 |
| Chen Q et al. | Digestion of triacylglycerols containing long-chain polyenoic fatty acids in vitro by colipase-dependent pancreatic lipase and human milk bile salt-stimulated lipase. | 1994 | Biochim. Biophys. Acta | pmid:8280776 |
| Kuklev DV et al. | [Synthesis of monoepoxides of arachidonic, eicosapentaenoic, and docosahexaenoic acids]. | 1993 | Bioorg. Khim. | pmid:8285925 |
| Makrides M et al. | The effect of dietary fat on the developing brain. | 1993 | J Paediatr Child Health | pmid:8286154 |
| Sanjurjo P et al. | Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. | 1993 | Horm. Metab. Res. | pmid:8288163 |
| Chin JP et al. | Indomethacin inhibits the effects of dietary supplementation with marine oils on vasoconstriction of human forearm resistance vessels in vivo. | 1993 | J. Hypertens. | pmid:8301104 |
| Neuringer M | Cerebral cortex docosahexaenoic acid is lower in formula-fed than in breast-fed infants. | 1993 | Nutr. Rev. | pmid:8302494 |
| Matsumoto K et al. | Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8302921 |
| Mundal HH et al. | The effect of N-3 fatty acids and nifedipine on platelet function in hypertensive males. | 1993 | Thromb. Res. | pmid:8303664 |
| Danno K et al. | Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models. | 1993 | Arch. Dermatol. Res. | pmid:8304784 |
| Rossi E and Costa M | Fish oil derivatives as a prophylaxis of recurrent miscarriage associated with antiphospholipid antibodies (APL): a pilot study. | 1993 | Lupus | pmid:8305926 |
| Arbuckle LD et al. | Formula 18:2(n-6) and 18:3(n-3) content and ratio influence long-chain polyunsaturated fatty acids in the developing piglet liver and central nervous system. | 1994 | J. Nutr. | pmid:8308579 |
| Bazan NG et al. | Pathways for the uptake and conservation of docosahexaenoic acid in photoreceptors and synapses: biochemical and autoradiographic studies. | 1993 | Can. J. Physiol. Pharmacol. | pmid:8313233 |
| Carlson SE et al. | Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8317386 |
| Yeh YY et al. | Maternal dietary fish oil enriches docosahexaenoate levels in brain subcellular fractions of offspring. | 1993 | J. Neurosci. Res. | pmid:8320752 |
| Swinbanks D | Fish-oil miracle additive brings benefits to some. | 1993 | Nature | pmid:8321302 |
| Gordon WC and Bazan NG | Visualization of [3H]docosahexaenoic acid trafficking through photoreceptors and retinal pigment epithelium by electron microscopic autoradiography. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:8325748 |
| Martinez M et al. | Docosahexaenoic acid--a new therapeutic approach to peroxisomal-disorder patients: experience with two cases. | 1993 | Neurology | pmid:8327143 |
| Moore SA | Cerebral endothelium and astrocytes cooperate in supplying docosahexaenoic acid to neurons. | 1993 | Adv. Exp. Med. Biol. | pmid:8333338 |
| Clark WF et al. | Dietary protein restriction versus fish oil supplementation in the chronic remnant nephron model. | 1993 | Clin. Nephrol. | pmid:8334756 |
| Scheurlen M et al. | Fish oil preparations rich in docosahexaenoic acid modify platelet responsiveness to prostaglandin-endoperoxide/thromboxane A2 receptor agonists. | 1993 | Biochem. Pharmacol. | pmid:8347146 |
| Hamazaki T et al. | Effect of intravenous administration of docosahexaenoic acid emulsion on blood glucose and insulin concentrations in diabetic rats. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8352442 |
| Hodge J et al. | Differential utilization of eicosapentaenoic acid and docosahexaenoic acid in human plasma. | 1993 | Lipids | pmid:8355578 |
| Abu-Zeid YA et al. | No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum blood stage parasites in vitro. | 1993 | Eur J Clin Nutr | pmid:8365384 |
| Anderson GJ et al. | Uptake of docosahexaenoic acid by microvessels from developing rat brain. | 1993 | Life Sci. | pmid:8366771 |
| Otten W et al. | A high omega 3 fatty acid diet alters fatty acid composition of heart, liver, kidney, adipose tissue and skeletal muscle in swine. | 1993 | Ann. Nutr. Metab. | pmid:8373137 |
| Nishio K et al. | Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C. | 1993 | Proc. Soc. Exp. Biol. Med. | pmid:8389049 |
| Nakamura N et al. | Intravenous infusion of tridocosahexaenoyl-glycerol emulsion into rabbits. Effects on leukotriene B4/5 production and fatty acid composition of plasma and leukocytes. | 1993 | J. Clin. Invest. | pmid:8397222 |
| Wang N and Anderson RE | Transport of 22:6n-3 in the plasma and uptake into retinal pigment epithelium and retina. | 1993 | Exp. Eye Res. | pmid:8405189 |
| Robinson DR et al. | Modification of spleen phospholipid fatty acid composition by dietary fish oil and by n-3 fatty acid ethyl esters. | 1993 | J. Lipid Res. | pmid:8409773 |
| Robinson DR et al. | Suppression of autoimmune disease by dietary n-3 fatty acids. | 1993 | J. Lipid Res. | pmid:8409774 |
| Arbuckle LD and Innis SM | Docosahexaenoic acid is transferred through maternal diet to milk and to tissues of natural milk-fed piglets. | 1993 | J. Nutr. | pmid:8410357 |
| Yonekubo A et al. | Dietary fish oil alters rat milk composition and liver and brain fatty acid composition of fetal and neonatal rats. | 1993 | J. Nutr. | pmid:8410361 |
| Kohlschütter A et al. | Low erythrocyte plasmalogen and plasma docosahexaenoic acid (DHA) in juvenile neuronal ceroid-lipofuscinosis (JNCL). | 1993 | J. Inherit. Metab. Dis. | pmid:8411986 |
| Nettleton JA | Are n-3 fatty acids essential nutrients for fetal and infant development? | 1993 | J Am Diet Assoc | pmid:8417094 |
| Speake BK et al. | Tissue-specific changes in lipid composition and lipoprotein lipase activity during the development of the chick embryo. | 1993 | Biochim. Biophys. Acta | pmid:8418884 |
| Wagner BA et al. | Increased generation of lipid-derived and ascorbate free radicals by L1210 cells exposed to the ether lipid edelfosine. | 1993 | Cancer Res. | pmid:8428351 |
| Svensson BG et al. | Fatty acid composition of serum phosphatidylcholine in healthy subjects consuming varying amounts of fish. | 1993 | Eur J Clin Nutr | pmid:8436091 |
| Stillwell W et al. | Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. | 1993 | Lipids | pmid:8441334 |
| Stillwell W et al. | Use of merocyanine (MC540) in quantifying lipid domains and packing in phospholipid vesicles and tumor cells. | 1993 | Biochim. Biophys. Acta | pmid:8443220 |
| Nariai T et al. | Intravenously injected radiolabelled fatty acids image brain tumour phospholipids in vivo: differential uptakes of palmitate, arachidonate and docosahexaenoate. | 1993 | Clin. Exp. Metastasis | pmid:8444007 |
| Willumsen N et al. | Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats. | 1993 | J. Lipid Res. | pmid:8445337 |
| Fleischhauer FJ et al. | Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients. | 1993 | J. Am. Coll. Cardiol. | pmid:8450169 |