| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Neuroaxonal Dystrophies | D019150 | 3 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okada M et al. | The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. | 1996 | Neuroscience | pmid:8834389 |
| Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
| Brossard N et al. | Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. | 1996 | Am. J. Clin. Nutr. | pmid:8839503 |
| Leaf A et al. | Long chain polyunsaturated fatty acids and visual function in preterm infants. | 1996 | Early Hum. Dev. | pmid:8842638 |
| Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
| Karmali RA | Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. | 1996 | Nutrition | pmid:8850210 |
| Reithmann C et al. | Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8857587 |
| Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
| Saito M et al. | An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8866256 |
| Hamano H et al. | Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. | 1996 | J. Neurophysiol. | pmid:8867135 |
| Liu W et al. | Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. | 1995 | Kobe J Med Sci | pmid:8869009 |
| Stillwell W et al. | Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. | 1996 | Biochemistry | pmid:8873602 |
| Oski FA | Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. | 1996 | Nutrition | pmid:8875527 |
| Berkenboom G et al. | Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. | 1996 | Cardiovasc Drugs Ther | pmid:8877082 |
| Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
| Hughes DA and Pinder AC | Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. | 1996 | Biochem. Soc. Trans. | pmid:8878933 |
| Alessandri JM et al. | Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. | 1996 | Reprod. Nutr. Dev. | pmid:8881596 |
| Lambert MS et al. | Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. | 1996 | Br. J. Nutr. | pmid:8881715 |
| Dahlan W et al. | Fish meal lecithin as alternative precursor of docosahexaenoate and choline. | 1996 | Biomed. Environ. Sci. | pmid:8886341 |
| Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
| Abbate R et al. | n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888356 |
| Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
| Farkas K et al. | Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8896327 |
| Ohno T et al. | Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. | 1996 | Jpn. J. Physiol. | pmid:8899494 |
| Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
| Vreugdenhil M et al. | Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8901621 |
| Yamada K et al. | Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8906631 |
| Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
| Retterstøl K et al. | The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8908151 |
| Crosby AJ et al. | Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. | 1996 | Biochim. Biophys. Acta | pmid:8908152 |
| Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
| Marignani PA and Sebaldt RJ | The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. | 1996 | J. Nutr. | pmid:8914943 |
| Hamazaki T et al. | Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. | 1996 | J. Nutr. | pmid:8914949 |
| Raederstorff D et al. | Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917124 |
| Zerouga M et al. | Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. | 1996 Sep-Oct | Anticancer Res. | pmid:8917399 |
| Carballeira NM et al. | Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8925444 |
| Santos FF et al. | Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. | 1995-1996 | Int Ophthalmol | pmid:8926126 |
| Agren JJ et al. | Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. | 1996 | Eur J Clin Nutr | pmid:8933125 |
| Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
| De Craemer D et al. | Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. | 1996 | Lipids | pmid:8934448 |
| Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
| Poling JS et al. | Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. | 1996 | Neuropharmacology | pmid:8938727 |
| Suzuki Y et al. | Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. | 1996 | Acta Paediatr Jpn | pmid:8942014 |
| Katoku Y et al. | Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. | 1996 | Am. J. Clin. Nutr. | pmid:8942411 |
| Reinboth JJ et al. | Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. | 1996 | Exp. Eye Res. | pmid:8943700 |
| Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
| Ohira T et al. | Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. | 1996 | J. Cancer Res. Clin. Oncol. | pmid:8954167 |
| Garratt JC et al. | Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8957264 |