DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Nutrition Disorders D009748 6 associated lipids
Obesity D009765 29 associated lipids
Optic Nerve Diseases D009901 6 associated lipids
Pain D010146 64 associated lipids
Pain, Postoperative D010149 13 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Parkinson Disease D010300 53 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Periodontitis D010518 22 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Vyncke KE et al. Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. 2013 Nutrition pmid:23312763
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Méndez L et al. Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. 2013 Free Radic. Biol. Med. pmid:23159545
Cooke M et al. Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. 2013 Mol. Cell. Endocrinol. pmid:23159987
Al-Hilal M et al. Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. 2013 J. Lipid Res. pmid:23160180
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Faizan M et al. Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). 2013 Int J Vitam Nutr Res pmid:25008014
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García-Layana A et al. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. 2013 Nutrients pmid:23434908
Williams JJ et al. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. 2013 PLoS ONE pmid:23437099
Mayer-Davis EJ et al. Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. 2013 Diabetes Care pmid:23801797
Kaur G et al. Orally administered [¹⁴C]DPA and [¹⁴C]DHA are metabolised differently to [¹⁴C]EPA in rats. 2013 Br. J. Nutr. pmid:22578196
Bagley HN et al. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. 2013 J Obes pmid:23533720
Dangour AD and Allen E Do omega-3 fats boost brain function in adults? Are we any closer to an answer? 2013 Am. J. Clin. Nutr. pmid:23535110
Kitamura F et al. Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. 2013 J Oleo Sci pmid:23535307
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Sugasini D and Lokesh BR Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. 2013 Mol. Cell. Biochem. pmid:23812902
Fukui M et al. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. 2013 J. Cell. Biochem. pmid:22903547
Stark MJ et al. Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. 2013 Reproduction pmid:23813449
Rupp TP et al. Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. 2013 Cardiology pmid:23816637
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Wu Z et al. Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. 2013 Brain Res. Bull. pmid:23817050
Zhang G et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23553837
Rayapudi S et al. Vitamin A and fish oils for retinitis pigmentosa. 2013 Cochrane Database Syst Rev pmid:24357340
Santos-Soto IJ et al. Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. 2013 PLoS ONE pmid:24349072
Nakamoto K et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. 2013 PLoS ONE pmid:24349089
Terrando N et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 2013 FASEB J. pmid:23709617
Fietkau R et al. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. 2013 Cancer pmid:23765693
Jiang LH et al. Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. 2013 Pharm Biol pmid:23767459
Weiss GA et al. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. 2013 Lipids Health Dis pmid:23767972
Kagan ML et al. Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. 2013 Lipids Health Dis pmid:23855409
Lee HN and Surh YJ Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. 2013 Biochem. Pharmacol. pmid:23856291
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Eickmeier O et al. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. 2013 Mucosal Immunol pmid:22785226
Hamaoka N et al. Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. 2013 J. Food Sci. pmid:23915081
Jing K et al. Omega-3 polyunsaturated fatty acids and cancer. 2013 Anticancer Agents Med Chem pmid:23919748
Pagán A et al. Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. 2013 Am. J. Physiol. Endocrinol. Metab. pmid:23921142
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Harris WS et al. Docosahexaenoic acid ethyl esters ineffective? 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23671065
Trofimiuk E and Braszko JJ Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. 2013 Physiol. Behav. pmid:23672853
Harris WS et al. Omega-3 fatty acids and cardiovascular disease: new developments and applications. 2013 Postgrad Med pmid:24200766
Ding N et al. Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. 2013 J Oleo Sci pmid:24200935
Yee LD et al. The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. 2013 Mol Nutr Food Res pmid:23213007
Kilpinen L et al. Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. 2013 J. Lipid Res. pmid:23271708
Becerir C et al. The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. 2013 J Enzyme Inhib Med Chem pmid:22591320
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Andrade-Vieira R et al. Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. 2013 Cancer Biol. Ther. pmid:24025358
Leggieri E et al. Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. 2013 Minerva Pediatr. pmid:24051972
Li D et al. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. 2013 Mucosal Immunol pmid:23462912
Zou Z et al. Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. 2013 J. Lipid Res. pmid:24052576
Song X et al. Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. 2013 J. Agric. Food Chem. pmid:24053543
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Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
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Bispo P et al. Preparation of triacylglycerols rich in omega-3 fatty acids from sardine oil using a Rhizomucor miehei lipase: focus in the EPA/DHA ratio. 2014 Appl. Biochem. Biotechnol. pmid:24293255
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Nozue T et al. Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study. 2014 Cardiovasc Diabetol pmid:24410834
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