DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Retinal Detachment D012163 10 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Choline Deficiency D002796 16 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Fleming JA and Kris-Etherton PM The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. 2014 Adv Nutr pmid:25398754
Lagarde M et al. Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. 2014 Biochimie pmid:25223888
Lager S et al. Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". 2014 Am. J. Physiol., Cell Physiol. pmid:25452383
Gilbert K et al. Resolvin D1, a metabolite of omega-3 polyunsaturated fatty acid, decreases post-myocardial infarct depression. 2014 Mar Drugs pmid:25402828
Wales KM et al. N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. 2014 PLoS ONE pmid:25398022
Hsiao HM et al. Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. 2014 J. Immunol. pmid:25320283
Arnardottir HH et al. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. 2014 J. Immunol. pmid:25217168
Metcalf RG et al. U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery. 2014 Eur J Clin Nutr pmid:24169465
Bremer AA et al. Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. 2014 J. Nutr. pmid:24108131
Rodrigues PO et al. Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats. 2014 Br. J. Nutr. pmid:24775714
Papanikolaou Y et al. U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. 2014 Nutr J pmid:24694001
Al-Zaubai N et al. Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor. 2014 J. Pharmacol. Exp. Ther. pmid:25077525
Djoussé L et al. Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. 2014 Eur J Nutr pmid:24395612
Heemskerk MM et al. Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. 2014 J. Lipid Res. pmid:25320342
Gong J et al. Maresin 1 mitigates LPS-induced acute lung injury in mice. 2014 Br. J. Pharmacol. pmid:24697684
Abe E et al. Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. 2014 PLoS ONE pmid:25090090
Ottosson NE et al. Drug-induced ion channel opening tuned by the voltage sensor charge profile. 2014 J. Gen. Physiol. pmid:24420769
Li S et al. The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. 2014 Oncotarget pmid:25004114
Hong SH et al. Docosahexaenoic acid confers enduring neuroprotection in experimental stroke. 2014 J. Neurol. Sci. pmid:24433927
Mulder KA et al. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. 2014 PLoS ONE pmid:24427279
Portillo-Reyes V et al. Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8-12 years old malnourished Mexican children: a randomized, double-blind, placebo and treatment clinical trial. 2014 Res Dev Disabil pmid:24508294
Oh DY et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. 2014 Nat. Med. pmid:24997608
Marklund M et al. A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. 2014 J. Nutr. pmid:25080537
Purushothaman D et al. Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. 2014 Genet. Mol. Res. pmid:25078588
Domenichiello AF et al. Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. 2014 J. Lipid Res. pmid:24212299
Arafiles KH et al. Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid. 2014 Appl. Microbiol. Biotechnol. pmid:25086614
Koutsos A et al. Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study. 2014 Cytokine pmid:24485322
Di Gregorio E et al. ELOVL5 mutations cause spinocerebellar ataxia 38. 2014 Am. J. Hum. Genet. pmid:25065913
Sokolov EI et al. [Value of Fatty acids in formation of thrombotic status in patients with ischemic heart disease]. 2014 Kardiologiia pmid:25177882
Aslan M et al. A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy. 2014 Lipids Health Dis pmid:24694037
Gregory MK and James MJ Functional characterization of the duck and turkey fatty acyl elongase enzymes ELOVL5 and ELOVL2. 2014 J. Nutr. pmid:24919687
Norris JM et al. Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. 2014 Diabetologia pmid:24240437
Dai XW et al. Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. 2014 Atherosclerosis pmid:24401220
Yamanushi TT et al. Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats. 2014 J. Nutr. pmid:24523492
Aursnes M et al. Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. 2014 J. Nat. Prod. pmid:24576195
Meagher KA et al. Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration. 2014 JAMA Ophthalmol pmid:24525935
Arnold C et al. Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration--reply. 2014 JAMA Ophthalmol pmid:24525936
Brasky TM et al. Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort. 2014 Am. J. Clin. Nutr. pmid:24500149
Sánchez-Reyes OB et al. Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. 2014 Eur. J. Pharmacol. pmid:24239485
Nobili V et al. Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. 2014 PLoS ONE pmid:24505350
Tateishi N et al. Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. 2014 Lipids Health Dis pmid:24507383
Zhang M et al. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. 2014 J. Neurosci. pmid:24478369
Kabeya N et al. Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. 2014 J. Biotechnol. pmid:24389067
Casanova E et al. Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. 2014 Biochim. Biophys. Acta pmid:24486445
Li X et al. Production of structured phosphatidylcholine with high content of DHA/EPA by immobilized phospholipase A₁-catalyzed transesterification. 2014 Int J Mol Sci pmid:25170810
AlSaleh A et al. Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults. 2014 J. Nutr. pmid:24401815
Paterniti I et al. Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. 2014 J Neuroinflammation pmid:24405628
Chen J et al. Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. 2014 Toxicol. Appl. Pharmacol. pmid:24709673
Recchiuti A et al. Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages. 2014 FASEB J. pmid:24692596
Colas RA et al. Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. 2014 Am. J. Physiol., Cell Physiol. pmid:24696140
Liu Y et al. The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase Aâ‚‚ via GPR120 receptor to produce prostaglandin Eâ‚‚ and plays an anti-inflammatory role in macrophages. 2014 Immunology pmid:24673159
Røsjø E et al. Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. 2014 J. Neuroimmunol. pmid:24713402
Koizumi K et al. Lipid and fatty acids of three edible myctophids, Diaphus watasei, Diaphus suborbitalis, and Benthosema pterotum: high levels of icosapentaenoic and docosahexaenoic acids. 2014 J Oleo Sci pmid:24717543
Létondor A et al. Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats. 2014 Br. J. Nutr. pmid:25331622
Xue M et al. Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo. 2014 J. Nutr. Biochem. pmid:24290517
Kim W et al. Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. 2014 Br. J. Nutr. pmid:23962659
Kermack AJ et al. A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). 2014 BMC Womens Health pmid:25407227
Wang JL et al. Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. 2014 J. Food Sci. pmid:24446860
Giovannelli J et al. Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007. 2014 J Acad Nutr Diet pmid:24083967
Zhang B et al. Polyunsaturated fatty acids for the prevention of atrial fibrillation after cardiac surgery: an updated meta-analysis of randomized controlled trials. 2014 J Cardiol pmid:23911138
Rius B et al. Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis. 2014 FASEB J. pmid:24249635
Choi EY et al. DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. 2014 Br. J. Nutr. pmid:24252501
Liu M et al. Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. 2014 Lipids pmid:24254970
Shinohara M et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 2014 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25217660
Hutchins-Wiese HL et al. High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. 2014 Nutr Cancer pmid:24274259
Yao QH et al. ω-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro. 2014 Mol Med Rep pmid:24276408
Desai A et al. Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. 2014 PLoS ONE pmid:24475126
Amiri-Jami M et al. Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis subsp. cremoris MG1363. 2014 Appl. Microbiol. Biotechnol. pmid:24389665
James MJ et al. Pitfalls in the use of randomised controlled trials for fish oil studies with cardiac patients. 2014 Br. J. Nutr. pmid:24933212
Chang D et al. Serum free fatty acids level in senile cataract. 2014 J Am Coll Nutr pmid:25079310
Purcell R et al. High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial. 2014 Am. J. Clin. Nutr. pmid:25099540
Hernández E et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. 2013 Sep-Oct Allergy Asthma Proc pmid:23998234
Harris WS et al. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. 2013 Sep-Oct J Clin Lipidol pmid:24079284
Tatsuno I et al. Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. 2013 Nov-Dec J Clin Lipidol pmid:24314359
Igarashi M et al. Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24209500
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Tatsuno I et al. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. 2013 May-Jun J Clin Lipidol pmid:23725919
Nishimura RY et al. Breast milk fatty acid composition of women living far from the coastal area in Brazil. 2013 May-Jun J Pediatr (Rio J) pmid:23669215
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Piñeiro-Corrales G et al. [Role of omega-3 fatty acids in cardiovascular disease prevention]. 2013 Jan-Feb Nutr Hosp pmid:23808424
Cederholm T et al. ω-3 fatty acids in the prevention of cognitive decline in humans. 2013 Adv Nutr pmid:24228198
Pande G et al. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. 2013 J. Agric. Food Chem. pmid:24117100
Murphy EJ A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. 2013 J. Neurochem. pmid:24117623
Méndez L et al. Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. 2013 Free Radic. Biol. Med. pmid:23159545
Paschoal VA et al. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. 2013 Lipids pmid:23086551
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Sugasini D and Lokesh BR Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. 2013 Mol. Cell. Biochem. pmid:23812902
Qadhi R et al. Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. 2013 Toxicol. Lett. pmid:23523905
Davidson MH Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. 2013 Curr. Opin. Lipidol. pmid:24184945
Merendino N et al. Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. 2013 Biomed Res Int pmid:23762838
Hunina LM et al. [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. 2013 Fiziol Zh pmid:23713352
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Ramprasath VR et al. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. 2013 Lipids Health Dis pmid:24304605
Fecchio C et al. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. 2013 PLoS ONE pmid:24312431
Dabkowski ER et al. Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. 2013 Cardiovasc Drugs Ther pmid:24013804
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Qu L et al. Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. 2013 Appl. Biochem. Biotechnol. pmid:24061873