DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Retinal Detachment D012163 10 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Choline Deficiency D002796 16 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Carlson SE et al. DHA supplementation and pregnancy outcomes. 2013 Am. J. Clin. Nutr. pmid:23426033
Goustard-Langelier B et al. Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. 2013 J. Nutr. Biochem. pmid:23036607
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Wijendran V et al. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24075244
Satkunendrarajah K and Fehlings MG Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. 2013 Exp. Neurol. pmid:23994716
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
Baum SJ EPA and DHA: distinct yet essential n-3 fatty acids. 2012 Sep-Oct J Clin Lipidol pmid:23009786
Castro González MI et al. [Renal patient's diet: Can fish be included?]. 2012 Sep-Oct Nutr Hosp pmid:23478696
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
Sanz París A et al. [Proposed profile of omega 3 fatty acids in enteral nutrition]. 2012 Nov-Dec Nutr Hosp pmid:23588426
Brown WV From the editor. 2012 Nov-Dec J Clin Lipidol pmid:23312044
Derosa G et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. 2012 Nov-Dec J Clin Lipidol pmid:23312051
Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Lee SM et al. Characterization of lecithin isolated from anchovy (Engraulis japonica) residues deoiled by supercritical carbon dioxide and organic solvent extraction. 2012 J. Food Sci. pmid:22757698
Keim SA et al. Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. 2012 Matern Child Nutr pmid:21615865
Petrie JR et al. Metabolic engineering plant seeds with fish oil-like levels of DHA. 2012 PLoS ONE pmid:23145108
López-Alarcón M et al. Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. 2012 Nutrition pmid:22079797
Skulas-Ray AC et al. Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. 2012 Ann Behav Med pmid:22865498
Le HD et al. Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038210
Towhidi A and Parks JE Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. 2012 J. Assist. Reprod. Genet. pmid:22869241
Tillman EM et al. Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038211
Fasano E et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. 2012 Biochim. Biophys. Acta pmid:22898250
Tyburczy C et al. Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. 2012 Br. J. Nutr. pmid:22040360
Schmitt D et al. Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. 2012 Food Chem. Toxicol. pmid:22898615
Serini S et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. 2012 Carcinogenesis pmid:22045024
An WS et al. Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. 2012 Nutr Res pmid:22901557
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Betancor MB et al. Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. 2012 Lipids pmid:23086553
Hou L et al. Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart. 2012 Cardiovasc Diabetol pmid:23057715
Pineda-Peña EA et al. Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. 2012 Eur. J. Pharmacol. pmid:23063544
Berson EL et al. ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. 2012 Arch. Ophthalmol. pmid:22332205
Beezhold BL and Johnston CS Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. 2012 Nutr J pmid:22333737
Rondanelli M et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. 2012 Nutr Neurosci pmid:22334085
Rockett BD et al. Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. 2012 J. Lipid Res. pmid:22315394
Hjorth E and Freund-Levi Y Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. 2012 Curr Opin Clin Nutr Metab Care pmid:22316559
Liu RZ et al. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. 2012 J. Pathol. pmid:22322885
Bragt MC and Mensink RP Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. 2012 Nutr Metab Cardiovasc Dis pmid:21429719
D'Eliseo D et al. Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression. 2012 J. Nutr. Biochem. pmid:21684140
Contreras GA et al. Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. 2012 J. Dairy Sci. pmid:23040031
Skender B et al. Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. 2012 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23069883
Xue B et al. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. 2012 PLoS ONE pmid:23071533
König K et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235080
Schmitt D et al. Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. 2012 Food Chem. Toxicol. pmid:22960629
Waldron MK et al. Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. 2012 Lipids pmid:22252853
Huang TY et al. A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. 2012 Bioresour. Technol. pmid:22929740
Browning LM et al. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. 2012 Am. J. Clin. Nutr. pmid:22932281
Feng Z et al. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. 2012 Antioxid. Redox Signal. pmid:21905985
Moreno-Indias I et al. The effect of diet and DHA addition on the sensory quality of goat kid meat. 2012 Meat Sci. pmid:21907501
Alvarez-Nölting R et al. Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. 2012 Neurochem. Res. pmid:21909958
Cortina MS et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. 2012 Arch. Ophthalmol. pmid:21911652
Rupp H et al. Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". 2012 Can. J. Physiol. Pharmacol. pmid:22188440
Peters BS et al. The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. 2012 Clin Ther pmid:22212377
Munro IA and Garg ML Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. 2012 Br. J. Nutr. pmid:22214842
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Basselin M et al. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. 2012 Brain Res. Bull. pmid:22178644
van der Meij BS et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. 2012 Eur J Clin Nutr pmid:22234041
Deike E et al. The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. 2012 J Ren Nutr pmid:22285316
Trépanier MO et al. Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. 2012 Epilepsy Res. pmid:22285511
Wu MH et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. 2012 J. Nutr. Biochem. pmid:22285823
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
Johnson M et al. Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. 2012 Atten Defic Hyperact Disord pmid:22753087
Quinn EA and Kuzawa CW A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. 2012 Acta Paediatr. pmid:22759234
Turk HF et al. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. 2012 PLoS ONE pmid:22761867
Hacioglu G et al. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. 2012 Folia Histochem. Cytobiol. pmid:22763967
Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Moallem U and Zachut M Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. 2012 J. Dairy Sci. pmid:22720961
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Oblozinský M et al. New pharmaceutical insights related to the pathways of PUFAs. 2012 Ceska Slov Farm pmid:23251954
Kwak SM et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. 2012 Arch. Intern. Med. pmid:22493407
Liu SH et al. Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. 2012 Brain Res. pmid:22440676
Trikalinos TA et al. Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. 2012 J Clin Epidemiol pmid:22047889
Lorenzetti A et al. Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. 2012 Acta Biomed pmid:23393918
Glover KE et al. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. 2012 J. Dairy Sci. pmid:22612917
Corsetto PA et al. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. 2012 Cell Biochem. Biophys. pmid:22622660
Bell S et al. The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. 2012 Clin. Nephrol. pmid:22595386
Hajjaji N et al. Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. 2012 Cancer Chemother. Pharmacol. pmid:22610354
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. 2012 Br. J. Nutr. pmid:22591907
Njoroge SW et al. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. 2012 J. Lipid Res. pmid:22095831
Angulo J et al. Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. 2012 J. Sci. Food Agric. pmid:22549272
Wielinga PY et al. Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. 2012 Mol Nutr Food Res pmid:22611002
Zhou SJ et al. Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. 2012 Am. J. Clin. Nutr. pmid:22552037
Calder PC Long-chain fatty acids and inflammation. 2012 Proc Nutr Soc pmid:22369781
Kelley DS and Adkins Y Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. 2012 Proc Nutr Soc pmid:22369859
Bernstein AM et al. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. 2012 J. Nutr. pmid:22113870
Yui K et al. Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. 2012 J Clin Psychopharmacol pmid:22370992
Finocchiaro C et al. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. 2012 Br. J. Nutr. pmid:22114792
Crnkovic S et al. Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²⁺-dependent induction of oxidative stress. 2012 Free Radic. Biol. Med. pmid:22391221