DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Proteinuria D011507 30 associated lipids
Catalepsy D002375 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Vyncke KE et al. Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. 2013 Nutrition pmid:23312763
Yu Y et al. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. 2013 J. Nutr. Biochem. pmid:23337348
Chen F et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. 2013 Innate Immun pmid:23339927
Xu J et al. Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. 2013 FEBS J. pmid:24128189
Kimura R et al. DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. 2013 J. Lipid Res. pmid:24133194
Casey JM et al. Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. 2013 Lipids Health Dis pmid:24139088
Chang CY et al. Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. 2013 J. Nutr. Biochem. pmid:24139673
Kautharapu KB et al. Growth condition optimization for docosahexaenoic acid (DHA) production by Moritella marina MP-1. 2013 Appl. Microbiol. Biotechnol. pmid:23111600
Méndez L et al. Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. 2013 Free Radic. Biol. Med. pmid:23159545
Cooke M et al. Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. 2013 Mol. Cell. Endocrinol. pmid:23159987
Al-Hilal M et al. Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. 2013 J. Lipid Res. pmid:23160180
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Larson MK et al. Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. 2013 Am. J. Physiol., Cell Physiol. pmid:23174566
Mussi SV et al. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. 2013 Eur J Pharm Sci pmid:23178339
Klingler M et al. Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. 2013 Br. J. Nutr. pmid:22874641
Faizan M et al. Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). 2013 Int J Vitam Nutr Res pmid:25008014
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Betancor MB et al. Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141617
Rai AK et al. Bioefficacy of EPA-DHA from lipids recovered from fish processing wastes through biotechnological approaches. 2013 Food Chem pmid:23017395
Kurihara T et al. Resolvin D2 restores neutrophil directionality and improves survival after burns. 2013 FASEB J. pmid:23430978
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Kondo T et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. 2013 Cell Stem Cell pmid:23434393
García-Layana A et al. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. 2013 Nutrients pmid:23434908
Williams JJ et al. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. 2013 PLoS ONE pmid:23437099
Kamolrat T and Gray SR The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. 2013 Biochem. Biophys. Res. Commun. pmid:23438435
Cieslik M et al. Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. 2013 Neurochem. Int. pmid:23439385
Nielsen G et al. Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. 2013 Basic Clin. Pharmacol. Toxicol. pmid:23724868
Mayer-Davis EJ et al. Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. 2013 Diabetes Care pmid:23801797
Kaur G et al. Orally administered [¹⁴C]DPA and [¹⁴C]DHA are metabolised differently to [¹⁴C]EPA in rats. 2013 Br. J. Nutr. pmid:22578196
Bagley HN et al. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. 2013 J Obes pmid:23533720
Dangour AD and Allen E Do omega-3 fats boost brain function in adults? Are we any closer to an answer? 2013 Am. J. Clin. Nutr. pmid:23535110
Kitamura F et al. Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. 2013 J Oleo Sci pmid:23535307
Mischoulon D and Freeman MP Omega-3 fatty acids in psychiatry. 2013 Psychiatr. Clin. North Am. pmid:23538073
Koltsida O et al. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. 2013 EMBO Mol Med pmid:23584892
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Li J et al. Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. 2013 OMICS pmid:23586678
Sugasini D and Lokesh BR Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. 2013 Mol. Cell. Biochem. pmid:23812902
Fukui M et al. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. 2013 J. Cell. Biochem. pmid:22903547
Stark MJ et al. Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. 2013 Reproduction pmid:23813449
Rupp TP et al. Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. 2013 Cardiology pmid:23816637
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Wu Z et al. Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. 2013 Brain Res. Bull. pmid:23817050
Berman DR et al. Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. 2013 Neonatology pmid:23817197
Singhal A et al. Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. 2013 J Am Heart Assoc pmid:23817470
Ribeiro T et al. Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. 2013 Br. Poult. Sci. pmid:24397512
Mozaffarian D et al. Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. 2013 Ann. Intern. Med. pmid:23546563
Zhang G et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23553837
Rayapudi S et al. Vitamin A and fish oils for retinitis pigmentosa. 2013 Cochrane Database Syst Rev pmid:24357340
Santos-Soto IJ et al. Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. 2013 PLoS ONE pmid:24349072
Nakamoto K et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. 2013 PLoS ONE pmid:24349089
Terrando N et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 2013 FASEB J. pmid:23709617
Fietkau R et al. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. 2013 Cancer pmid:23765693
Jiang LH et al. Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. 2013 Pharm Biol pmid:23767459
Weiss GA et al. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. 2013 Lipids Health Dis pmid:23767972
Codabaccus MB et al. Restoration of EPA and DHA in rainbow trout (Oncorhynchus mykiss) using a finishing fish oil diet at two different water temperatures. 2013 Food Chem pmid:23768353
Correia Bacarin C et al. Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. 2013 Physiol. Behav. pmid:23770426
Martins DA et al. Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. 2013 Mar Drugs pmid:23807546
Kagan ML et al. Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. 2013 Lipids Health Dis pmid:23855409
Lee HN and Surh YJ Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. 2013 Biochem. Pharmacol. pmid:23856291
Benton D et al. Supplementation with DHA and the psychological functioning of young adults. 2013 Br. J. Nutr. pmid:22715808
Xie W et al. Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. 2013 Lab. Invest. pmid:23857007
Li Q et al. A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). 2013 Fish Shellfish Immunol. pmid:23859878
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Eickmeier O et al. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. 2013 Mucosal Immunol pmid:22785226
Titova OE et al. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. 2013 Age (Dordr) pmid:22791395
Klek S et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. 2013 Clin Nutr pmid:22796064
Barber E et al. Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24012207
Nicholson T et al. The role of marine n-3 fatty acids in improving cardiovascular health: a review. 2013 Food Funct pmid:23325431
Hamaoka N et al. Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. 2013 J. Food Sci. pmid:23915081
Jing K et al. Omega-3 polyunsaturated fatty acids and cancer. 2013 Anticancer Agents Med Chem pmid:23919748
Pagán A et al. Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. 2013 Am. J. Physiol. Endocrinol. Metab. pmid:23921142
Sheets KG et al. Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. 2013 Mol. Vis. pmid:23922492
Baselga-Escudero L et al. Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. 2013 PLoS ONE pmid:23922812
Tanghe S et al. Echium oil and linseed oil as alternatives for fish oil in the maternal diet: Blood fatty acid profiles and oxidative status of sows and piglets. 2013 J. Anim. Sci. pmid:23658328
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Harris WS et al. Docosahexaenoic acid ethyl esters ineffective? 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23671065
Trofimiuk E and Braszko JJ Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. 2013 Physiol. Behav. pmid:23672853
Cheng R et al. Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. 2013 World J. Microbiol. Biotechnol. pmid:23292648
Chen J et al. Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. 2013 Inhal Toxicol pmid:23293968
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Harris WS et al. Omega-3 fatty acids and cardiovascular disease: new developments and applications. 2013 Postgrad Med pmid:24200766
Ding N et al. Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. 2013 J Oleo Sci pmid:24200935
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Yee LD et al. The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. 2013 Mol Nutr Food Res pmid:23213007
Kilpinen L et al. Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. 2013 J. Lipid Res. pmid:23271708
Storck Lindholm E et al. Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23273824
Atwell K et al. Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. 2013 J Paediatr Child Health pmid:23279074
Becerir C et al. The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. 2013 J Enzyme Inhib Med Chem pmid:22591320
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639
Innis SM et al. Long chain omega-3 fatty acids: micronutrients in disguise. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22709913
Andrade-Vieira R et al. Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. 2013 Cancer Biol. Ther. pmid:24025358
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Leggieri E et al. Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. 2013 Minerva Pediatr. pmid:24051972
Li D et al. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. 2013 Mucosal Immunol pmid:23462912
Zou Z et al. Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. 2013 J. Lipid Res. pmid:24052576
Song X et al. Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. 2013 J. Agric. Food Chem. pmid:24053543
Nobili V et al. The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. 2013 J Med Food pmid:24074360
Weintraub H Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. 2013 Atherosclerosis pmid:24075771
Stulnig G et al. Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. 2013 Atherosclerosis pmid:24075775
Uusitalo L et al. Fatty acids in serum and diet--a canonical correlation analysis among toddlers. 2013 Matern Child Nutr pmid:22066932