| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leaf A | Omega-3 fatty acids and prevention of ventricular fibrillation. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784457 |
| Denzlinger C et al. | Modulation of the endogenous leukotriene production by fish oil and vitamin E. | 1995 | J Lipid Mediat Cell Signal | pmid:7780681 |
| Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
| Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
| Makrides M et al. | Are long-chain polyunsaturated fatty acids essential nutrients in infancy? | 1995 | Lancet | pmid:7769900 |
| Li ZY and Ward OP | Production of docosahexaenoic acid by Thraustochytrium roseum. | 1994 | J. Ind. Microbiol. | pmid:7765049 |
| Lucien FP et al. | Separation of biomolecules using supercritical fluid extraction. | 1993 May-Jun | Australas Biotechnol | pmid:7763846 |
| Pawlosky RJ and Salem N | Ethanol exposure causes a decrease in docosahexaenoic acid and an increase in docosapentaenoic acid in feline brains and retinas. | 1995 | Am. J. Clin. Nutr. | pmid:7762532 |
| Onwude JL et al. | A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. | 1995 | Br J Obstet Gynaecol | pmid:7756226 |
| Al MD et al. | The essential fatty acid status of mother and child in pregnancy-induced hypertension: a prospective longitudinal study. | 1995 | Am. J. Obstet. Gynecol. | pmid:7755079 |
| Rose DP et al. | Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. | 1995 | J. Natl. Cancer Inst. | pmid:7752256 |
| Ishinaga M et al. | Daily intakes of fatty acids, sterols, and phospholipids by Japanese women and serum cholesterol. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7751974 |
| Byard RW et al. | Sudden infant death syndrome: effect of breast and formula feeding on frontal cortex and brainstem lipid composition. | 1995 | J Paediatr Child Health | pmid:7748681 |
| Decsi T et al. | Essential fatty acids in full term infants fed breast milk or formula. | 1995 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:7743279 |
| Farquharson J et al. | Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex. | 1995 | Arch. Dis. Child. | pmid:7741563 |
| Eritsland J et al. | Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. | 1995 | Thromb. Res. | pmid:7740525 |
| Innis SM | The 1993 Borden Award Lecture. Fatty acid requirements of the newborn. | 1994 | Can. J. Physiol. Pharmacol. | pmid:7736339 |
| Chirouze V et al. | Red blood cell fatty acid composition in low-birth-weight infants fed either human milk or formula during the first months of life. | 1994 | Acta Paediatr Suppl | pmid:7734796 |
| Achard F et al. | Interconversions and distinct metabolic fate of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in bovine aortic endothelial cells. | 1995 | Biochim. Biophys. Acta | pmid:7734441 |
| Nada MA et al. | On the rate-limiting step in the beta-oxidation of polyunsaturated fatty acids in the heart. | 1995 | Biochim. Biophys. Acta | pmid:7734439 |
| Araya J et al. | [Effect of a diet supplemented with soybean oil or fish oil on the reversibility of docosahexaenoic acid deficiency (22:6w3) in the brain and erythrocytes of rats]. | 1994 | Arch Latinoam Nutr | pmid:7733788 |
| Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
| Hoffman DR and Birch DG | Docosahexaenoic acid in red blood cells of patients with X-linked retinitis pigmentosa. | 1995 | Invest. Ophthalmol. Vis. Sci. | pmid:7730010 |
| Maehle L et al. | Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines. | 1995 | Br. J. Cancer | pmid:7710930 |
| Hexeberg S et al. | Docosahexaenoic acid induces lipid accumulation in myocardial cells of rats. | 1994 | Scand. J. Clin. Lab. Invest. | pmid:7709170 |
| Sanjurjo P et al. | Polyunsaturated fatty acid status in patients with phenylketonuria. | 1994 | J. Inherit. Metab. Dis. | pmid:7707693 |
| Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
| Hamosh M | Long chain polyunsaturated fatty acids in neonatal nutrition. | 1994 | J Am Coll Nutr | pmid:7706584 |
| Saito M | Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. | 1994 | Ann. Nutr. Metab. | pmid:7702359 |
| Chapman GE and Wallace HM | Spermine prevents lipid peroxidation induced by essential fatty acids in human breast cancer cells. | 1994 | Biochem. Soc. Trans. | pmid:7698423 |
| Niebylski CD and Salem N | A calorimetric investigation of a series of mixed-chain polyunsaturated phosphatidylcholines: effect of sn-2 chain length and degree of unsaturation. | 1994 | Biophys. J. | pmid:7696478 |
| Hughes DA et al. | N-3 polyunsaturated fatty acids (PUFA) modulate the expression of functionally associated molecules on human monocytes. | 1995 | Biochem. Soc. Trans. | pmid:7672332 |
| Mano MT et al. | Fish oils modulate blood pressure and vascular contractility in the rat and vascular contractility in the primate. | 1995 | Blood Press. | pmid:7670652 |
| Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
| Schweich MD et al. | Effect of oxygen concentration on production of ethane and thiobarbituric acid-reactive substances by peroxidizing lung and liver homogenates and formation of ethanol by peroxidizing docosahexaenoic acid preparations under hyperoxic conditions. | 1995 | J Toxicol Environ Health | pmid:7666491 |
| Innis SM et al. | Marine and freshwater fish oil varying in arachidonic, eicosapentaenoic and docosahexaenoic acids differ in their effects on organ lipids and fatty acids in growing rats. | 1995 | J. Nutr. | pmid:7666244 |
| Sanjurjo P et al. | Influence of fatty fish intake during pregnancy in the polyunsaturated fatty acids of erythrocyte phospholipids in the mother at labor and newborn infant. | 1995 | Acta Obstet Gynecol Scand | pmid:7660762 |
| Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
| Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
| Lee J et al. | Soluble-binding proteins for docosahexaenoic acid are present in neural retina. | 1995 | Invest. Ophthalmol. Vis. Sci. | pmid:7657541 |
| Agostoni C et al. | Docosahexaenoic acid status and developmental quotient of healthy term infants. | 1995 | Lancet | pmid:7651024 |
| Wakabayashi S et al. | In vivo imaging of brain incorporation of fatty acids and of 2-deoxy-D-glucose demonstrates functional and structural neuroplastic effects of chronic unilateral visual deprivation in rats. | 1995 | Brain Res. | pmid:7648253 |
| Bell MV et al. | Dietary deficiency of docosahexaenoic acid impairs vision at low light intensities in juvenile herring (Clupea harengus L.). | 1995 | Lipids | pmid:7637565 |
| VanRollins M | Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7636743 |
| Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
| Stordy BJ | Benefit of docosahexaenoic acid supplements to dark adaptation in dyslexics. | 1995 | Lancet | pmid:7623560 |
| Uauy R and De Andraca I | Human milk and breast feeding for optimal mental development. | 1995 | J. Nutr. | pmid:7623166 |
| Engler MB et al. | Vasorelaxant properties of n-3 polyunsaturated fatty acids in aortas from spontaneously hypertensive and normotensive rats. | 1994 | J Cardiovasc Risk | pmid:7614421 |
| Fournier A et al. | Influence of the phospholipid content in docosahexaenoic acid on electrophysiology and contraction of rat heart muscle cells. | 1995 | Cardioscience | pmid:7605899 |
| Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |