| MeSH term | MeSH ID | Detail |
|---|---|---|
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthus Reaction | D001183 | 8 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Atrial Fibrillation | D001281 | 16 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hirayama S et al. | Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:14985685 |
| Jiang Y et al. | Fatty acid composition and squalene content of the marine microalga Schizochytrium mangrovei. | 2004 | J. Agric. Food Chem. | pmid:14995120 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Chiu CC et al. | Omega-3 polyunsaturated fatty acids for postpartum depression. | 2004 | Am. J. Obstet. Gynecol. | pmid:15002412 |
| Moriguchi K et al. | Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. | 2004 Mar-Apr | Ophthalmic Res. | pmid:15017106 |
| Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
| Hsu JM et al. | The effect of dietary docosahexaenoic acid on the expression of porcine lipid metabolism-related genes. | 2004 | J. Anim. Sci. | pmid:15032424 |
| Gorson DM | Fish oil supplementation and ulcerative colitis. | 1992 | Ann. Intern. Med. | pmid:1503361 |
| Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
| Hejazi MA and Wijffels RH | Milking of microalgae. | 2004 | Trends Biotechnol. | pmid:15038924 |
| Horrocks LA and Farooqui AA | Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041028 |
| Hogg RJ and Wyatt RJ | A randomized controlled trial of mycophenolate mofetil in patients with IgA nephropathy [ISRCTN62574616]. | 2004 | BMC Nephrol | pmid:15043759 |
| Ota Y et al. | Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV-infected patients. | 2004 | Nutrition | pmid:15043851 |
| Shahdat H et al. | Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order. | 2004 | Life Sci. | pmid:15051424 |
| Theobald HE et al. | LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. | 2004 | Am. J. Clin. Nutr. | pmid:15051597 |
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| Marszalek JR et al. | Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. | 2004 | J. Biol. Chem. | pmid:15051725 |
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| Murata Y et al. | Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056911 |
| Hoffman DR et al. | A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa. | 2004 | Am. J. Ophthalmol. | pmid:15059710 |
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| Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
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| Denys A et al. | Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid. | 2004 | FEBS Lett. | pmid:15094063 |
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| Leu GZ et al. | Anti-HCV activities of selective polyunsaturated fatty acids. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15110784 |
| Stark KD and Holub BJ | Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. | 2004 | Am. J. Clin. Nutr. | pmid:15113713 |
| Nkondjock A and Ghadirian P | Intake of specific carotenoids and essential fatty acids and breast cancer risk in Montreal, Canada. | 2004 | Am. J. Clin. Nutr. | pmid:15113726 |
| Weisman D et al. | Efficacy of omega-3 fatty acid supplementation in primary and secondary prevention of coronary heart disease. | 2004 | Isr. Med. Assoc. J. | pmid:15115262 |
| Hamazaki T and Hirayama S | The effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder-a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:15116088 |
| Onodera K et al. | Zooxanthellactone, a novel gamma-lactone-type oxylipine from dinoflagellates of Symbiodinium sp.: structure, distribution, and biological activity. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15118313 |
| Pan M et al. | Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. | 2004 | J. Clin. Invest. | pmid:15124019 |
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| Agaba M et al. | Zebrafish cDNA encoding multifunctional Fatty Acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. | 2004 May-Jun | Mar. Biotechnol. | pmid:15129327 |
| Steger B and Colvin HP | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15131835 |
| Young GS et al. | Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. | 2004 | Lipids | pmid:15134138 |
| Du C et al. | Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease. | 2004 | J. Nutr. Biochem. | pmid:15135151 |
| Levant B et al. | Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. | 2004 | Behav. Brain Res. | pmid:15135968 |
| Yazawa K | [Importance of "health foods", EPA and DHA, for preventive medicine]. | 2004 | Rinsho Byori | pmid:15137325 |
| Hamam F and Shahidi F | Synthesis of structured lipids via acidolysis of docosahexaenoic acid single cell oil (DHASCO) with capric acid. | 2004 | J. Agric. Food Chem. | pmid:15137833 |
| Zhang M and Fritsche KL | Fatty acid-mediated inhibition of IL-12 production by murine macrophages is independent of PPARgamma. | 2004 | Br. J. Nutr. | pmid:15137925 |
| Payet M et al. | Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients. | 2004 | Br. J. Nutr. | pmid:15137931 |
| Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
| Niu SL et al. | Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. | 2004 | J. Biol. Chem. | pmid:15145938 |
| Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
| Mukherjee PK et al. | Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15152078 |
| Thomas B et al. | Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women. | 2004 | Eur J Clin Nutr | pmid:15162132 |
| Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
| Thomas TR et al. | Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions. | 2004 | Metab. Clin. Exp. | pmid:15164323 |
| Blanco PG et al. | Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses. | 2004 | Am. J. Obstet. Gynecol. | pmid:15167843 |
| Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
| Roig-Pérez S et al. | Lipid peroxidation induced by DHA enrichment modifies paracellular permeability in Caco-2 cells: protective role of taurine. | 2004 | J. Lipid Res. | pmid:15175351 |
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| AbuGhazaleh AA and Jenkins TC | Disappearance of docosahexaenoic and eicosapentaenoic acids from cultures of mixed ruminal microorganisms. | 2004 | J. Dairy Sci. | pmid:15202649 |
| Broadhurst CL et al. | (13)C nuclear magnetic resonance spectra of natural undiluted lipids: docosahexaenoic-rich phospholipid and triacylglycerol from fish. | 2004 | J. Agric. Food Chem. | pmid:15212476 |
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| Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
| Cockeran R et al. | Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. | 2004 | Infect. Immun. | pmid:15213185 |
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| Menoyo D et al. | Adaptation of lipid metabolism, tissue composition and flesh quality in gilthead sea bream (Sparus aurata) to the replacement of dietary fish oil by linseed and soyabean oils. | 2004 | Br. J. Nutr. | pmid:15230986 |
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| Erdogan H et al. | Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15253883 |
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| Calderon F and Kim HY | Docosahexaenoic acid promotes neurite growth in hippocampal neurons. | 2004 | J. Neurochem. | pmid:15287904 |
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