DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Hypercalciuria D053565 4 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Atherosclerosis D050197 85 associated lipids
Dyslipidemias D050171 7 associated lipids
Decapitation D049248 2 associated lipids
Diabetes Complications D048909 4 associated lipids
Premature Birth D047928 6 associated lipids
Malnutrition D044342 6 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mussi SV et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. 2014 Pharm. Res. pmid:24522814
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Cao DH et al. Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. 2004 Pharmacol. Biochem. Behav. pmid:15582673
Minami M et al. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. 1997 Pharmacol. Biochem. Behav. pmid:9408223
Obajimi O et al. Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. 2005 Pharmacol. Res. pmid:15967385
Galli C Health implications of DHA. 1999 Pharmacol. Res. pmid:10479461
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Schjøtt J et al. Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. 1996 Pharmacol. Toxicol. pmid:8878248
Paulsen JE et al. A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. 1998 Pharmacol. Toxicol. pmid:9527643
Sametz W et al. Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). 2000 Pharmacology pmid:10754452
Burns T et al. Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. 2007 Pharmacotherapy pmid:17461697
McKenney JM and Sica D Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. 2007 Pharmacotherapy pmid:17461707
Du J et al. Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. 2010 Pharmazie pmid:20383947
Gederaas OA et al. Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. 2005 Photochem. Photobiol. Sci. pmid:15803209
Kello M et al. PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. 2010 Photochem. Photobiol. Sci. pmid:20714672
Easley JT et al. AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. 2016 Physiol Rep pmid:27694530
Kunesová M et al. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. 2006 Physiol Res pmid:15857162
Levant B et al. Developmental effects of dietary n-3 fatty acids on activity and response to novelty. 2010 Physiol. Behav. pmid:20457171
Correia Bacarin C et al. Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. 2013 Physiol. Behav. pmid:23770426
Trofimiuk E and Braszko JJ Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. 2013 Physiol. Behav. pmid:23672853
Bandaru SS et al. Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior. 2010 Physiol. Behav. pmid:19914265
Turner N et al. Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. 2006 May-Jun Physiol. Biochem. Zool. pmid:16691518
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Guihéneuf F et al. Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. 2013 Phytochemistry pmid:23528573
Mansour MP et al. The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. 2003 Phytochemistry pmid:12711135
Zhou XR et al. Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. 2007 Phytochemistry pmid:17291553
Innis SM Essential fatty acid transfer and fetal development. 2005 Placenta pmid:15837071
Johnsen GM et al. Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. 2011 Placenta pmid:21741084
Xu Y et al. Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. 2008 Placenta pmid:18829104
Johnsen GM et al. Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. 2009 Placenta pmid:19880178
Tobin KA et al. Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. 2009 Placenta pmid:19010540
Serna-Saldivar SO et al. Effect of DHA containing oils and powders on baking performance and quality of white pan bread. 2006 Plant Foods Hum Nutr pmid:17031604
Jin F et al. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. 2012 Plant Foods Hum Nutr pmid:22538527
Metz JG et al. Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: release of the products as free fatty acids. 2009 Plant Physiol. Biochem. pmid:19272783
Andersen MK et al. Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. 2016 PLoS Genet. pmid:27341449
Mirza M et al. Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. 2013 PLoS ONE pmid:24124525
Umhau JC et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. 2013 PLoS ONE pmid:24098376
Qin Y et al. Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. 2015 PLoS ONE pmid:26226139
Petrie JR et al. Metabolic engineering plant seeds with fish oil-like levels of DHA. 2012 PLoS ONE pmid:23145108
Wales KM et al. N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. 2014 PLoS ONE pmid:25398022
Wang X et al. The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). 2012 PLoS ONE pmid:23110176
Jansen D et al. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. 2013 PLoS ONE pmid:24086523
Abdelmoaty S et al. Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. 2013 PLoS ONE pmid:24086560
Sugasini D and Subbaiah PV Rate of acyl migration in lysophosphatidylcholine (LPC) is dependent upon the nature of the acyl group. Greater stability of sn-2 docosahexaenoyl LPC compared to the more saturated LPC species. 2017 PLoS ONE pmid:29117232
Zhu G et al. Enhanced production of docosahexaenoic acid in mammalian cells. 2014 PLoS ONE pmid:24788769
Martin CR et al. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. 2014 PLoS ONE pmid:24892762
Nakamoto K et al. Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. 2017 PLoS ONE pmid:28723961
Chatterjee A et al. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. 2014 PLoS ONE pmid:25409514
Abe E et al. Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. 2014 PLoS ONE pmid:25090090
Mulder KA et al. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. 2014 PLoS ONE pmid:24427279
Shulse CN and Allen EE Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. 2011 PLoS ONE pmid:21629834
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Xue B et al. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. 2012 PLoS ONE pmid:23071533
Kisos H et al. Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. 2012 PLoS ONE pmid:23077527
Joseph MS et al. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. 2012 PLoS ONE pmid:22911773
Correia M et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. 2013 PLoS ONE pmid:23577140
Bonilla DL et al. Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis. 2010 PLoS ONE pmid:20526363
Kulkarni A et al. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. 2011 PLoS ONE pmid:21423696
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Bhatia HS et al. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. 2011 PLoS ONE pmid:22163304
Singh A et al. Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 2013 PLoS ONE pmid:23844124
Arsenault D et al. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. 2011 PLoS ONE pmid:21383850
Zúñiga J et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. 2011 PLoS ONE pmid:22174823
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Lee Y et al. Analysis of endogenous lipids during intestinal wound healing. 2017 PLoS ONE pmid:28800645
Virtanen JK et al. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. 2012 PLoS ONE pmid:22815906
Nobili V et al. Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. 2014 PLoS ONE pmid:24505350
Katakura M et al. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. 2015 PLoS ONE pmid:26485038
Astarita G et al. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. 2010 PLoS ONE pmid:20838618
Giroud S et al. Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). 2013 PLoS ONE pmid:23650545
Turk HF et al. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. 2012 PLoS ONE pmid:22761867
Khairallah RJ et al. Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. 2012 PLoS ONE pmid:22479624
Fecchio C et al. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. 2013 PLoS ONE pmid:24312431
Kang KS et al. Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. 2010 PLoS ONE pmid:20421971
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Ishikado A et al. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. 2013 PLoS ONE pmid:23936010
Nuez-Ortín WG et al. Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. 2016 PLoS ONE pmid:27556399
Zhao Y et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. 2011 PLoS ONE pmid:21246057
Alsharari ZD et al. Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. 2017 PLoS ONE pmid:28125662
Khaddaj-Mallat R et al. Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. 2016 PLoS ONE pmid:27935998
Zhao Z et al. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. 2016 PLoS ONE pmid:27880795
Gladine C et al. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. 2014 PLoS ONE pmid:24558496
Park J et al. Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. 2014 PLoS ONE pmid:24465474
Xiao G et al. Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. 2013 PLoS ONE pmid:24066055
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Labrousse VF et al. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. 2012 PLoS ONE pmid:22662127
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Mottola G et al. Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. 2017 PLoS ONE pmid:28362840
de Waal H et al. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. 2014 PLoS ONE pmid:24475144
Eickmeier O et al. Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis. 2017 PLoS ONE pmid:28158236
Desai A et al. Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. 2014 PLoS ONE pmid:24475126
Correia M et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. 2012 PLoS ONE pmid:22529974