Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Engström K et al. | Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats. | 2009 | Ups. J. Med. Sci. | pmid:19961266 |
Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
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Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
Xue H et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. | 2006 | Vascul. Pharmacol. | pmid:16616699 |
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Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
Nesbitt GH et al. | Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. | 2003 | Vet. Dermatol. | pmid:12662263 |
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Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
Xia Y et al. | [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. | 2007 | Wei Sheng Yan Jiu | pmid:17953212 |
Gong Q et al. | [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring]. | 2009 | Wei Sheng Yan Jiu | pmid:20047222 |
McDaniel JC et al. | Effect of n-3 oral supplements on the n-6/n-3 ratio in young adults. | 2010 | West J Nurs Res | pmid:19915202 |
Cendrowski W | [MaxEpa in multiple sclerosis]. | 1985 | Wiad. Lek. | pmid:3913158 |
D'Almeida A et al. | Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. | 1992 | Women Health | pmid:1492408 |
Robinson JG et al. | Omega-3 fatty acids and cognitive function in women. | 2010 | Womens Health (Lond) | pmid:20088735 |
Habbel P et al. | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. | 2009 | World J. Gastroenterol. | pmid:19266600 |
Maciejewska D et al. | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. | 2015 | World J. Gastroenterol. | pmid:25574105 |
Sui YH et al. | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | World J. Gastroenterol. | pmid:26937141 |
Cheng R et al. | Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. | 2013 | World J. Microbiol. Biotechnol. | pmid:23292648 |
Lagarde M et al. | Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. | 2001 | World Rev Nutr Diet | pmid:11935951 |
Sato M et al. | Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid. | 2001 | World Rev Nutr Diet | pmid:11935956 |
Hamazaki T et al. | Effect of docosahexaenoic acid on hostility. | 2001 | World Rev Nutr Diet | pmid:11935969 |
Crawford MA et al. | Docosahexaenoic acid and cerebral evolution. | 2001 | World Rev Nutr Diet | pmid:11935972 |
Suzuki H et al. | Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. | 2001 | World Rev Nutr Diet | pmid:11935973 |
Nestel P | Fish oil fatty acids beneficially modulate vascular function. | 2001 | World Rev Nutr Diet | pmid:11935976 |
Leaf A and Kang JX | Omega 3 fatty acids and cardiovascular disease. | 1998 | World Rev Nutr Diet | pmid:9648502 |
Hoffman DR and Birch DG | Omega 3 fatty acid status in patients with retinitis pigmentosa. | 1998 | World Rev Nutr Diet | pmid:9648504 |
Al MD et al. | The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. | 1994 | World Rev Nutr Diet | pmid:7856218 |
Barclay W et al. | Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. | 1998 | World Rev Nutr Diet | pmid:9648505 |
Abril R and Barclay W | Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. | 1998 | World Rev Nutr Diet | pmid:9648506 |
Martinez M | Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. | 1991 | World Rev Nutr Diet | pmid:1828923 |
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Hibbeln JR | Depression, suicide and deficiencies of omega-3 essential fatty acids in modern diets. | 2009 | World Rev Nutr Diet | pmid:19136836 |
Gruszfeld D and Socha P | Early nutrition and health: short- and long-term outcomes. | 2013 | World Rev Nutr Diet | pmid:24029784 |
Przyrembel H and Agostoni C | Growing-up milk: a necessity or marketing? | 2013 | World Rev Nutr Diet | pmid:24029786 |