Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Burdge GC | The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. | 1998 | Biochem. Soc. Trans. | pmid:9649756 |
Edwards R et al. | Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients. | 1998 | Biochem. Soc. Trans. | pmid:9649817 |
Monia ZA et al. | Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653768 |
Jolly CA et al. | Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654402 |
Kelley DS et al. | Dietary docosahexaenoic acid and immunocompetence in young healthy men. | 1998 | Lipids | pmid:9655370 |
Young C et al. | Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. | 1998 | Neurosci. Lett. | pmid:9655627 |
Hansen RA et al. | Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. | 1998 | Am. J. Vet. Res. | pmid:9659553 |
Grimsgaard S et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9665096 |
Hagve TA et al. | Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. | 1998 | Scand. J. Clin. Lab. Invest. | pmid:9670342 |
Martinez M and Vazquez E | MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders. | 1998 | Neurology | pmid:9674774 |
Guarini P et al. | Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. | 1998 | Inflammation | pmid:9675609 |
Nasa Y et al. | Long-term supplementation with eicosapentaenoic acid salvages cardiomyocytes from hypoxia/reoxygenation-induced injury in rats fed with fish-oil-deprived diet. | 1998 | Jpn. J. Pharmacol. | pmid:9681570 |
Connor WE et al. | Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. | 1998 | J. Lipid Res. | pmid:9684743 |
Infante JP and Huszagh VA | Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids. | 1998 | FEBS Lett. | pmid:9684854 |
Clandinin MT et al. | Docosahexaenoic acid increases thyroid-stimulating hormone concentration in male and adrenal corticotrophic hormone concentration in female weanling rats. | 1998 | J. Nutr. | pmid:9687541 |
de la Presa-Owens S et al. | Addition of triglycerides with arachidonic acid or docosahexaenoic acid to infant formula has tissue- and lipid class-specific effects on fatty acids and hepatic desaturase activities in formula-fed piglets. | 1998 | J. Nutr. | pmid:9687559 |
Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
Jarocka-Cyrta E et al. | Early dietary experience influences ontogeny of intestine in response to dietary lipid changes in later life. | 1998 | Am. J. Physiol. | pmid:9688652 |
Ohinata H et al. | Effect of dietary docosahexaenoic acid on in vitro thermogenesis and fatty acid compositions of brown adipose tissue. | 1998 | Jpn. J. Physiol. | pmid:9689148 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Campbell FM et al. | Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. | 1998 | Life Sci. | pmid:9698032 |
Birch EE et al. | Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. | 1998 | Pediatr. Res. | pmid:9702915 |
Shikano M et al. | 1a-docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9704018 |
Oudot F et al. | Polyunsaturated fatty acids influence prostanoid synthesis in vascular endothelial cells under hypoxia and reoxygenation. | 1998 | Int J Vitam Nutr Res | pmid:9706502 |
Petroni A et al. | The beta-oxidation of arachidonic acid and the synthesis of docosahexaenoic acid are selectively and consistently altered in skin fibroblasts from three Zellweger patients versus X-adrenoleukodystrophy, Alzheimer and control subjects. | 1998 | Neurosci. Lett. | pmid:9708853 |
Hawkins RA et al. | Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. | 1998 | J. Pathol. | pmid:9713361 |
Hibbeln JR et al. | Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. | 1998 | Biol. Psychiatry | pmid:9715354 |
Hibbeln JR et al. | A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. | 1998 | Biol. Psychiatry | pmid:9715355 |
Watkins SM et al. | Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. | 1998 | J. Lipid Res. | pmid:9717717 |
Birbes H et al. | Protein kinase C inhibitors stimulate arachidonic and docosahexaenoic acids release from uterine stromal cells through a Ca2+-independent pathway. | 1998 | FEBS Lett. | pmid:9720928 |
Kimura S et al. | Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9730013 |
Waldron MK et al. | Role of long-chain polyunsaturated n-3 fatty acids in the development of the nervous system of dogs and cats. | 1998 | J. Am. Vet. Med. Assoc. | pmid:9731252 |
Prisco D et al. | Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. | 1998 | Thromb. Res. | pmid:9733153 |
Decsi T et al. | Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: results from a randomized clinical trial. | 1998 | Ann. Nutr. Metab. | pmid:9745105 |
Crabtree JT et al. | Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. | 1998 | Mol. Cell. Biochem. | pmid:9746226 |
Suzuki A et al. | Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. | 1998 | J Pharm Sci | pmid:9758676 |
Mitchell DC et al. | Why is docosahexaenoic acid essential for nervous system function? | 1998 | Biochem. Soc. Trans. | pmid:9765880 |
Andriamampandry M et al. | Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K. | 1998 | C. R. Acad. Sci. III, Sci. Vie | pmid:9766191 |
Lii CK et al. | Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774170 |
Macleod JC et al. | The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsaturated fatty acids. | 1998 | Eur. J. Pharmacol. | pmid:9774258 |
Jenski LJ et al. | The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro. | 1998 | Lipids | pmid:9778134 |
Ikeda I et al. | Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. | 1998 | Lipids | pmid:9778137 |
Maurage C et al. | Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants. | 1998 | Biol. Neonate | pmid:9784633 |
Morley R | Nutrition and cognitive development. | 1998 | Nutrition | pmid:9785354 |
Rodriguez A et al. | Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks. | 1998 | Am. J. Obstet. Gynecol. | pmid:9790399 |
Scott DT et al. | Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? | 1998 | Pediatrics | pmid:9794989 |
Menard CR et al. | Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. | 1998 | J. Neurochem. | pmid:9798942 |
Kubo K et al. | Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9805370 |
Schofield M et al. | Cholesterol versus cholesterol sulfate: effects on properties of phospholipid bilayers containing docosahexaenoic acid. | 1998 | Chem. Phys. Lipids | pmid:9807808 |
Price SA and Tisdale MJ | Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid. | 1998 | Cancer Res. | pmid:9809986 |