DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Uveitis D014605 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Brain Neoplasms D001932 15 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Choline Deficiency D002796 16 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Blister D001768 16 associated lipids
Vascular Diseases D014652 16 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Brain Infarction D020520 17 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Carcinoma D002277 18 associated lipids
Down Syndrome D004314 18 associated lipids
Pregnancy Complications D011248 19 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Refsum Disease D012035 19 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Anemia D000740 21 associated lipids
Cachexia D002100 21 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Erythema D004890 22 associated lipids
Periodontitis D010518 22 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Hypoxia D000860 23 associated lipids
Birth Weight D001724 23 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Neuralgia D009437 28 associated lipids
Obesity D009765 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Proteinuria D011507 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Cataract D002386 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Burns D002056 34 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Heart Failure D006333 36 associated lipids
Lung Diseases D008171 37 associated lipids
Peritonitis D010538 38 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Hypotension D007022 41 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Asthma D001249 52 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Lagarde M et al. Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. 2001 World Rev Nutr Diet pmid:11935951
Sato M et al. Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid. 2001 World Rev Nutr Diet pmid:11935956
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Al MD et al. The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. 1994 World Rev Nutr Diet pmid:7856218
Bazan NG et al. Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. 1994 World Rev Nutr Diet pmid:7871812
Anderson RE et al. The accretion of docosahexaenoic acid in the retina. 1994 World Rev Nutr Diet pmid:7871813
von Houwelingen AC and Hornstra G Trans fatty acids in early human development. 1994 World Rev Nutr Diet pmid:7871822
Martinez M Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. 1994 World Rev Nutr Diet pmid:7871835
Martinez M Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. 1991 World Rev Nutr Diet pmid:1828923
SanGiovanni JP et al. Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration. 2009 World Rev Nutr Diet pmid:19136842
Gruszfeld D and Socha P Early nutrition and health: short- and long-term outcomes. 2013 World Rev Nutr Diet pmid:24029784
Przyrembel H and Agostoni C Growing-up milk: a necessity or marketing? 2013 World Rev Nutr Diet pmid:24029786
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
McDaniel JC et al. Omega-3 fatty acids effect on wound healing. 2008 May-Jun Wound Repair Regen pmid:18471252
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kimura S [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. 2000 Yakugaku Zasshi pmid:10920715
Nishinaka T et al. [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. 2013 Yakugaku Zasshi pmid:23649389
Okuyama H [Need to change the direction of cholesterol-related medication--a problem of great urgency]. 2005 Yakugaku Zasshi pmid:16272805
Ishiguro J et al. [Effects of ethyl eicosapentaenoate (EPA-E) and its metabolite on the drug and fatty acid metabolizing enzyme systems in rat liver]. 1988 Yakugaku Zasshi pmid:2841446
Li QC et al. [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. 1997 Yao Xue Xue Bao pmid:11596318
Qi AD et al. [Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]. 1992 Yao Xue Xue Bao pmid:1442036
Schmitt Y and Schneider H [The effect of highly unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology during their administration to patients undergoing chronic hemodialysis treatment]. 1993 Z Ernahrungswiss pmid:8237080
Wechsler JG et al. [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. 1989 Z Gastroenterol pmid:2756729
Gohlke H [Prevention of coronary disease and sudden death by nutrition]. 2004 Z Kardiol pmid:15021992
Obukhova GP et al. [A neuromorphological analysis of the motor area of the cerebral cortex in rat pups subjected to prenatal exposure to normal and pathological blood serum]. 1992 Jul-Aug Zh. Evol. Biokhim. Fiziol. pmid:1455957
Wu Q et al. [Effect of combination of docosahexaenoic acid and fluorouracil on human gastric carcinoma cell strain MGC803]. 2010 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:20236591
Chen R et al. [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. 2014 Zhonghua Jie He He Hu Xi Za Zhi pmid:24796591
Wang RX et al. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21624312
Lai LH et al. [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21781602
Dong PS et al. [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. 2012 Zhonghua Xin Xue Guan Bing Za Zhi pmid:22883096
Wang RX et al. [Effects of docosahexaenoic acid on action potential and transient outward potassium current on ventricular myocytes of Sprague-Dawley rat]. 2009 Zhonghua Xin Xue Guan Bing Za Zhi pmid:19719983
Lu G [The role of n-3 polyunsaturated fatty acid on coronary heart disease]. 1990 Zhonghua Xin Xue Guan Bing Za Zhi pmid:2150806
Hu SX and Yang JN [Biological effects of docosahexaenoic acid on the retina]. 2003 Zhonghua Yan Ke Za Zhi pmid:12894762
Yu XJ et al. [Effect of omega-3 long-chain polyunsaturated fatty acids on the cultured oligodendrocyte precursor cells]. 2009 Zhonghua Yi Xue Za Zhi pmid:19563717
Feng XG et al. [Antitumor effect of DHA compound in vitro and in vivo and its mechanism]. 2010 Zhonghua Zhong Liu Za Zhi pmid:20819480