Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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van de Lagemaat M et al. | Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21995887 |
Williard DE et al. | Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324227 |
Martin RE et al. | Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324228 |
Sayanova O and Napier JA | Transgenic oilseed crops as an alternative to fish oils. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21596549 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
Dijck-Brouwer DA et al. | Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589396 |
Lapillonne A and Jensen CL | Reevaluation of the DHA requirement for the premature infant. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19577914 |
Graf BA et al. | Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20580213 |
McNamara RK | The emerging role of omega-3 fatty acids in psychiatry. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930969 |
Shinto L et al. | Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19171471 |
Freeman MP | Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930971 |
Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
Jensen CL and Lapillonne A | Docosahexaenoic acid and lactation. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19632101 |
Gustafson KM et al. | Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23433688 |
Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
Peltier S et al. | Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083359 |
Brenna JT and Diau GY | The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18023566 |
Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Michael-Titus AT | Omega-3 fatty acids and neurological injury. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036801 |
Plourde M et al. | Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036804 |
Calon F and Cole G | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18037281 |
Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
Pifferi F et al. | n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18042368 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
Astarita G and Piomelli D | Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21543199 |
Nyuar KB et al. | Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23706881 |
Wittwer J and Hersberger M | The two faces of the 15-lipoxygenase in atherosclerosis. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17869078 |
Manna S et al. | Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18614344 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Honda KL et al. | Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25921297 |
Kearns SD and Haag M | The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445489 |
Gow RV et al. | Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664595 |
Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
Chechi K et al. | Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20688254 |
Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
Lokesh BR and Kinsella JE | Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846090 |
Makrides M | DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22698951 |
Van Biervliet S et al. | Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18276127 |
Matsumoto K et al. | Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8302921 |
Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |
Otto SJ et al. | Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907133 |
Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
Bryhn M et al. | The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16806871 |