Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Luquain C et al. | Bis(monoacylglycerol) phosphate in rat uterine stromal cells: structural characterization and specific esterification of docosahexaenoic acid. | 2000 | Biochem. J. | pmid:11042136 |
Garcia HS et al. | Synthesis of glycerides containing n-3 fatty acids and conjugated linoleic acid by solvent-free acidolysis of fish oil. | 2000 | Biotechnol. Bioeng. | pmid:11042555 |
Gerber MJ et al. | Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. | 2000 | J Am Diet Assoc | pmid:11043701 |
Hosokawa M et al. | Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation. | 2000 | J. Agric. Food Chem. | pmid:11052698 |
Surai PF et al. | Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. | 2000 | J. Reprod. Fertil. | pmid:11058441 |
Pakala R et al. | Vascular smooth muscle cells preloaded with eicosapentaenoic acid and docosahexaenoic acid fail to respond to serotonin stimulation. | 2000 | Atherosclerosis | pmid:11058699 |
Salem ML et al. | N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. | 2000 Sep-Oct | Anticancer Res. | pmid:11062743 |
Sherman MP | Human milk, fatty acids, and the immune response: a new glimpse. | 2000 | Am. J. Clin. Nutr. | pmid:11063429 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Smit EN et al. | Docosahexaenoic acid (DHA) status of breastfed malnourished infants and their mothers in North Pakistan. | 2000 | Adv. Exp. Med. Biol. | pmid:11065099 |
Lauritizen L et al. | Dietary fish and the docosahexaenoic acid (DHA) content of human milk. | 2000 | Adv. Exp. Med. Biol. | pmid:11065103 |
Savino F et al. | Arachidonic (AA) and docosahexaenoic (DHA) acid content in healthy infants fed with an HA milk formula supplemented with LCPUFA and in breast fed infants. | 2000 | Adv. Exp. Med. Biol. | pmid:11065107 |
Decsi T et al. | Low contribution of docosahexaenoic acid to the fatty acid composition of mature human milk in Hungary. | 2000 | Adv. Exp. Med. Biol. | pmid:11065108 |
Lopez-Alarcon M et al. | Illness-induced anorexia in the breast-fed infants. Role of IL-1beta and TNF-alpha. | 2000 | Adv. Exp. Med. Biol. | pmid:11065112 |
Lim SY and Suzuki H | Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice. | 2000 | Int J Vitam Nutr Res | pmid:11068705 |
Totland GK et al. | Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. | 2000 | Biol. Cell | pmid:11071041 |
Contreras MA et al. | Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. | 2000 | J. Neurochem. | pmid:11080190 |
Moriguchi T et al. | Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. | 2000 | J. Neurochem. | pmid:11080210 |
Diep QN et al. | Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. | 2000 | Hypertension | pmid:11082155 |
Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
Rissanen T et al. | Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. | 2000 | Circulation | pmid:11094031 |
Freedman SD et al. | Fatty acids in cystic fibrosis. | 2000 | Curr Opin Pulm Med | pmid:11100964 |
Lapillonne A et al. | The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. | 2000 | Pediatr. Res. | pmid:11102555 |
Wang M et al. | Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. | 2000 | Cancer Res. | pmid:11103817 |
Ikemoto A et al. | Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. | 2000 | Lipids | pmid:11104017 |
Decsi T et al. | Fatty acid composition of human milk in Hungary. | 2000 | Acta Paediatr. | pmid:11106060 |
Baldessarini RJ et al. | Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. | 2001 | Neuropsychopharmacology | pmid:11106876 |
Mezzano D et al. | Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. | 2000 | Thromb. Res. | pmid:11108902 |
Song JH et al. | Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. | 2000 | J. Nutr. | pmid:11110863 |
Auestad N | Infant nutrition--brain development--disease in later life. An introduction. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111164 |
Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
Stockard JE et al. | Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111168 |
de Urquiza AM et al. | Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. | 2000 | Science | pmid:11118147 |
Haban P et al. | Supplementation with long-chain n-3 fatty acids in non-insulin-dependent diabetes mellitus (NIDDM) patients leads to the lowering of oleic acid content in serum phospholipids. | 2000 | Eur J Nutr | pmid:11131366 |
Harel M et al. | Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. | 2000 | Lipids | pmid:11132186 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Sorbera LA et al. | Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). | 2001 | Biol. Reprod. | pmid:11133697 |
Mizota A et al. | Protective effects of dietary docosahexaenoic acid against kainate-induced retinal degeneration in rats. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11133871 |
Lauritzen L et al. | The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. | 2001 Jan-Mar | Prog. Lipid Res. | pmid:11137568 |
Reich EE et al. | Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Am. J. Pathol. | pmid:11141503 |
Hoffman DR et al. | Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11144440 |
Yokoyama A et al. | Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:11146390 |
Nagakura T et al. | Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. | 2000 | Eur. Respir. J. | pmid:11153584 |
Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
Otto SJ et al. | Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. | 2001 | Am. J. Clin. Nutr. | pmid:11157328 |
Williams C et al. | Stereoacuity at age 3.5 y in children born full-term is associated with prenatal and postnatal dietary factors: a report from a population-based cohort study. | 2001 | Am. J. Clin. Nutr. | pmid:11157330 |
Brand A et al. | Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. | 2001 | J. Neurochem. | pmid:11158263 |