Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pisani LF et al. | In vitro modulatory effect of omega-3 polyunsaturated fatty acid (EPA and DHA) on phagocytosis and ROS production of goat neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19395090 |
Lecchi C et al. | In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. | 2011 | Vet. J. | pmid:20889357 |
Filburn CR and Griffin D | Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. | 2005 | Vet. Ther. | pmid:15906268 |
Semenova EM and Converse CA | Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. | 2003 | Vision Res. | pmid:14611942 |
Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
Ter-Karapetian VA | [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. | 1994 | Voen Med Zh | pmid:8165800 |
Gladyshev MI et al. | [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. | 2006 | Vopr Pitan | pmid:16739608 |
Sergienko AA et al. | [Effects of docosahexaenoic and eicosapentaenoic acids on the state of metabolites of the prostacyclin I2--thromboxane A2 system in streptozotocin diabetes mellitus]. | 1992 Mar-Apr | Vopr Pitan | pmid:1387492 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Wu K et al. | [Effects of phytohormones on growth and DHA production by Thraustochytrium roseum]. | 2003 | Wei Sheng Wu Xue Bao | pmid:16276880 |