DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Basal Ganglia Diseases D001480 8 associated lipids
Biliary Atresia D001656 4 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Body Weight D001835 333 associated lipids
Bone Diseases, Metabolic D001851 9 associated lipids
Brain Neoplasms D001932 15 associated lipids
Breast Neoplasms D001943 24 associated lipids
Burns D002056 34 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Intracranial Arteriosclerosis D002537 4 associated lipids
Brain Ischemia D002545 89 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
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Freedman SD et al. A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570187
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Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
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Elsherbiny ME et al. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. 2013 Prog. Lipid Res. pmid:23981365
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Domenichiello AF et al. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? 2015 Prog. Lipid Res. pmid:25920364
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Blanchet J et al. Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. 2008 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18471948
Doornbos B et al. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18955102
Blachier F et al. Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis. 1988 Prostaglandins pmid:2834771
Kim HY and Salem N Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. 1989 Prostaglandins pmid:2541468
Mai J et al. A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. 1981 Prostaglandins pmid:6280241
Kim HY et al. Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. 1990 Prostaglandins pmid:2147773
Kim HY et al. Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets. 1990 Prostaglandins pmid:2147774
Fischer S et al. Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. 1987 Prostaglandins pmid:2829279
Hishinuma T et al. Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. 1997 Prostaglandins pmid:9261859
Claeys M et al. Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. 1986 Prostaglandins pmid:2951768
van de Lagemaat M et al. Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21995887
Yi SH et al. A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22000478
Williard DE et al. Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324227
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Yoshino S and Ellis EF Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550967
Martin RE et al. Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324228
Bégin ME et al. Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550969
Smithers LG et al. Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20417081
Aoki N et al. Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550971
Gow RV et al. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19230637
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Dijck-Brouwer DA et al. Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589396
Kris-Etherton PM et al. Dietary reference intakes for DHA and EPA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19525100
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Pakala R et al. Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328332
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Brenna JT and Salem N Workshop proceedings: DHA as a required nutrient. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19604681
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Marsen TA et al. Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1387231
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Rapoport SI et al. Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20226642
Peltier S et al. Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18083359
Saldanha LG et al. Workshop on DHA as a required nutrient: overview. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19643589
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Smithers LG et al. Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951004
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Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
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Qin Q et al. Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:19019647
Chechi K et al. Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20688254
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Alnajjar A et al. Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16650969
Storck Lindholm E et al. Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23273824
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van Goor SA et al. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19118992
Brown AJ et al. Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1836062
Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
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