DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Qu L et al. Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. 2011 Lett. Appl. Microbiol. pmid:21070268
Kim HW et al. Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. 2011 Biochim. Biophys. Acta pmid:21070866
Hashimoto M and Hossain S Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease. 2011 J. Pharmacol. Sci. pmid:21606627
Madden J et al. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. 2011 Annu. Rev. Nutr. pmid:21568708
Musto AE et al. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. 2011 Epilepsia pmid:21569016
Corsetto PA et al. Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. 2011 Lipids Health Dis pmid:21569413
Eckert GP et al. Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. 2011 Biochim. Biophys. Acta pmid:21036142
Bonnet N and Ferrari SL Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. 2011 J. Nutr. Biochem. pmid:21036590
Freeman MP et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. 2011 Menopause pmid:21037490
Chang WK et al. The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake. 2011 Int J Nanomedicine pmid:22072876
Vinayavekhin N and Saghatelian A Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. 2011 J. Am. Chem. Soc. pmid:21973308
Hull MA Omega-3 polyunsaturated fatty acids. 2011 Best Pract Res Clin Gastroenterol pmid:22122770
Wei MY and Jacobson TA Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. 2011 Curr Atheroscler Rep pmid:21975919
Turgut S et al. The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. 2011 J Basic Clin Physiol Pharmacol pmid:22865430
Kumosani TA and Moselhy SS Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. 2011 Hum Exp Toxicol pmid:20488854
Hung ND et al. Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. 2011 Inflammation pmid:20490641
Ruusunen A et al. Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. 2011 Eur J Nutr pmid:20574779
Zeng Y et al. Development of a temperature shift strategy for efficient docosahexaenoic acid production by a marine fungoid protist, Schizochytrium sp. HX-308. 2011 Appl. Biochem. Biotechnol. pmid:21120635
Itakura H et al. Relationships between plasma fatty acid composition and coronary artery disease. 2011 J. Atheroscler. Thromb. pmid:21099130
Sullivan JC et al. Modeling the primary oxidation in commercial fish oil preparations. 2011 Lipids pmid:21104333
Shulse CN and Allen EE Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment. 2011 Environ. Microbiol. pmid:21105981
Koletzko B et al. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. 2011 Am. J. Clin. Nutr. pmid:21106917
Lu FS et al. Oxidative stability of marine phospholipids in the liposomal form and their applications. 2011 Lipids pmid:21088919
Kalupahana NS et al. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. 2011 Adv Nutr pmid:22332072
Wiese DM et al. The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. 2011 Nutr Clin Pract pmid:21775642
Madec S et al. CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. 2011 Drug Metab. Dispos. pmid:21778351
Flachs P et al. Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. 2011 Diabetologia pmid:21779874
Molinari R et al. The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. 2011 Cancer Immunol. Immunother. pmid:21779875
Lai LH et al. [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21781602
Serhan CN and Petasis NA Resolvins and protectins in inflammation resolution. 2011 Chem. Rev. pmid:21766791
Shulse CN and Allen EE Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. 2011 PLoS ONE pmid:21629834
Okpala I et al. Pilot study of omega-3 fatty acid supplements in sickle cell disease. 2011 APMIS pmid:21635551
Hajjaji N et al. Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. 2011 Lipids pmid:21638063
Kuang YL et al. Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β. 2011 Am. J. Clin. Nutr. pmid:21653803
Roqueta-Rivera M et al. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. 2011 Biol. Reprod. pmid:21653892
Nakamoto K et al. Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. 2011 Eur. J. Pharmacol. pmid:21658380
Martin CR et al. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. 2011 J. Pediatr. pmid:21658712
McLaren JE et al. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. 2011 Lipids pmid:21822944
Kawabata T et al. Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. 2011 Lipids Health Dis pmid:21838914
Tian H et al. Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. 2011 Am. J. Pathol. pmid:21839062
Kimura F et al. Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. 2011 Lipids pmid:21901511
Lewis MD et al. Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. 2011 J Clin Psychiatry pmid:21903029
Kuipers RS et al. Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21903369
Weylandt KH et al. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. 2011 Carcinogenesis pmid:21421544
Stapleton RD et al. A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. 2011 Crit. Care Med. pmid:21423000
Kulkarni A et al. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. 2011 PLoS ONE pmid:21423696
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid by a newly isolated microalga, Aurantiochytrium sp. KRS101. 2011 Appl. Biochem. Biotechnol. pmid:21424706
Farias SE et al. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. 2011 J Trauma pmid:21427623
Makhoul Z et al. Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. 2011 Eur J Clin Nutr pmid:21427737
Nelson TL et al. Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. 2011 Eur J Nutr pmid:20706728
Bhatia HS et al. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. 2011 PLoS ONE pmid:22163304
Wagner K et al. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. 2011 Prostaglandins Other Lipid Mediat. pmid:21854866
Park CK et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. 2011 J. Neurosci. pmid:22171045
Zúñiga J et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. 2011 PLoS ONE pmid:22174823
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Song KS et al. Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. 2011 Pancreatology pmid:22213040
Meldrum SJ et al. The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. 2011 Contemp Clin Trials pmid:21718804
D'Alessandro A et al. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. 2011 J Proteomics pmid:21723426
Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
De Franceschi G et al. Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. 2011 J. Biol. Chem. pmid:21527634
Schnebelen C et al. Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. 2011 Nutr Res pmid:21530802
Glew RH et al. Low docosahexaenoic acid in the diet and milk of American Indian women in New Mexico. 2011 J Am Diet Assoc pmid:21515123
Courville AB et al. Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. 2011 Br. J. Nutr. pmid:21521543
Bradbury J Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. 2011 Nutrients pmid:22254110
Ferreira M et al. Effect of the nutritional status of semi-continuous microalgal cultures on the productivity and biochemical composition of Brachionus plicatilis. 2011 Mar. Biotechnol. pmid:21487686
Michaelsen KF et al. Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. 2011 Matern Child Nutr pmid:21366872
Smithers LG et al. Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. 2011 Am. J. Clin. Nutr. pmid:21490140
Sun C et al. DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. 2011 Mol. Biol. Rep. pmid:20383747
Hutchins HL et al. Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. 2011 J. Nutr. Biochem. pmid:20951563
Recchiuti A et al. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. 2011 FASEB J. pmid:20956612
Basselin M et al. Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. 2011 J. Cereb. Blood Flow Metab. pmid:20664612
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Klein CM and Jenkins TC Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. 2011 J. Dairy Sci. pmid:21854940
Miyazawa D et al. Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. 2011 Biomed. Res. pmid:21878731
Mazaki-Tovi M et al. Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. 2011 Am. J. Vet. Res. pmid:21879986
Kim HW et al. Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880477
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Parra-Cabrera S et al. Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. 2011 Matern Child Nutr pmid:21410881
Wang F et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. 2011 Curr. Mol. Med. pmid:21663587
Min Y et al. Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. 2011 Eur J Clin Nutr pmid:21386858
Feucht C and Patel DR Herbal medicines in pediatric neuropsychiatry. 2011 Pediatr. Clin. North Am. pmid:21281847
Galicia-Connolly EZ et al. Complementary, holistic, and integrative medicine: therapies for learning disabilities. 2011 Pediatr Rev pmid:21285298
Nobili V et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. 2011 Arch. Dis. Child. pmid:21233083
Aarsetoey H et al. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. 2011 Lipids pmid:21234696
Salm P et al. Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and arachidonic acid in plasma by high-performance liquid chromatography-tandem mass spectrometry. 2011 Biomed. Chromatogr. pmid:20737653
Ozsoy O et al. The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. 2011 Neurotox Res pmid:21234736
McNamara RK Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? 2011 Schizophr. Res. pmid:21276713
Taoka Y et al. Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304. 2011 J. Biosci. Bioeng. pmid:21216665
Umhau JC Docosahexaenoic acid supplementation and Alzheimer disease. 2011 JAMA pmid:21325181
Nowak M et al. Impact of polyunsaturated fatty acids on oxidized low density lipoprotein-induced U937 cell apoptosis. 2011 J. Atheroscler. Thromb. pmid:21325776
Murphy RA et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. 2011 Cancer pmid:21328326
Valera B et al. Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. 2011 Int J Circumpolar Health pmid:21329579
Furuhjelm C et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. 2011 Pediatr Allergy Immunol pmid:21332799
Sriram K Confusion between gamma-linolenic acid and gamma-linoleic acid. 2011 Crit. Care Med. pmid:22094528
Scott SD et al. Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. 2011 Enzyme Microb. Technol. pmid:22112910
Lecchi C et al. In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. 2011 Vet. J. pmid:20889357
Liu C and Cai WX [Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice]. 2011 Fa Yi Xue Za Zhi pmid:21604451