DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Lee HJ et al. Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. 2013 Int. J. Biochem. Cell Biol. pmid:24120851
Offman E et al. Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. 2013 Vasc Health Risk Manag pmid:24124374
Mirza M et al. Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. 2013 PLoS ONE pmid:24124525
Daak AA et al. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24095588
Galvao TF et al. Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:23103493
Hegarty B and Parker G Fish oil as a management component for mood disorders - an evolving signal. 2013 Curr Opin Psychiatry pmid:23108232
Ren LJ et al. Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. 2013 Bioprocess Biosyst Eng pmid:23108442
Tsuboi H et al. Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. 2013 Clin Nutr pmid:22901744
Lindberg M et al. Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. 2013 Br. J. Nutr. pmid:22846205
MacLean E et al. n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. 2013 Br. J. Nutr. pmid:22849952
Hajjaji N and Bougnoux P Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. 2013 Cancer Treat. Rev. pmid:22850619
Zong G et al. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. 2013 Eur J Nutr pmid:23179200
Poudyal H et al. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23026492
Hu Y et al. 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. 2013 Carcinogenesis pmid:23066085
Tang Y et al. Proresolution therapy for the treatment of delayed healing of diabetic wounds. 2013 Diabetes pmid:23043160
Izquierdo MS et al. Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. 2013 Br. J. Nutr. pmid:23046500
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Chien KL et al. A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. 2013 BMC Med Res Methodol pmid:23414574
Kasuya F et al. Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. 2013 J Enzyme Inhib Med Chem pmid:22299587
Maskrey BH et al. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. 2013 Mol Nutr Food Res pmid:23417926
Lapillonne A et al. Lipid needs of preterm infants: updated recommendations. 2013 J. Pediatr. pmid:23445847
West AA et al. Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. 2013 Am. J. Clin. Nutr. pmid:23446897
Sánchez-Martín MJ et al. Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. 2013 Chembiochem pmid:23447332
Hjorth E et al. Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. 2013 J. Alzheimers Dis. pmid:23481688
Lee MS et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. 2013 Nutrients pmid:23698161
Snodgrass RG et al. Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. 2013 J. Immunol. pmid:24043885
Yamaguchi M et al. Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. 2013 J Occup Health pmid:23574777
Correia M et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. 2013 PLoS ONE pmid:23577140
Weise C et al. Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. 2013 Pediatr Allergy Immunol pmid:23577592
De Genaro P et al. Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23580485
Hudson AG et al. Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. 2013 Nutr Cancer pmid:23530640
Pacetti D et al. Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). 2013 J. Agric. Food Chem. pmid:23531042
Lee HN et al. Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. 2013 J. Cell. Sci. pmid:23788426
Araújo JR et al. Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. 2013 J. Nutr. Biochem. pmid:23790250
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Xue Z et al. Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. 2013 Nat. Biotechnol. pmid:23873085
Pase MP and Stough C Describing a taxonomy of cognitive processes for clinical trials assessing cognition. 2013 Am. J. Clin. Nutr. pmid:23873682
Kuratko CN et al. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. 2013 Nutrients pmid:23877090
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Vigerust NF et al. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. 2013 Eur J Nutr pmid:22923017
Emmett R et al. Expanding awareness of docosahexaenoic acid during pregnancy. 2013 Nutrients pmid:23549329
Haller MJ et al. Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. 2013 Biol. Blood Marrow Transplant. pmid:23611977
Chen J et al. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. 2013 Food Chem. Toxicol. pmid:23590892
Damsgaard CT et al. n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. 2013 Br. J. Nutr. pmid:23591057
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Dalli J et al. Novel n-3 immunoresolvents: structures and actions. 2013 Sci Rep pmid:23736886
Finlin BS et al. Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. 2013 J. Nutr. Biochem. pmid:23528972
Rashid MA et al. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. 2013 J. Neurochem. pmid:23570577
Shiraishi M et al. Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. 2013 Nutr Res pmid:23746563
Azordegan N et al. Carcinogenesis alters fatty acid profile in breast tissue. 2013 Mol. Cell. Biochem. pmid:23180247
Vaezi R et al. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. 2013 Mar Drugs pmid:24351909
Thomas J et al. Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. 2013 J. Nutr. Biochem. pmid:23746933
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Chang G et al. Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. 2013 Bioresour. Technol. pmid:23747449
Zhang L et al. Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. 2013 Bioresour. Technol. pmid:23751810
Jung SB et al. Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. 2013 Biochem. Biophys. Res. Commun. pmid:23806688
Decsi T and Boehm G trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. 2013 Am. J. Clin. Nutr. pmid:23824720
Lundström SL et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. 2013 Mol Nutr Food Res pmid:23824870
Lohner S et al. Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. 2013 Nutr Res pmid:23827125
Kelly OJ et al. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. 2013 Nutr Res pmid:23827126
García-Sastre A Lessons from lipids in the fight against influenza. 2013 Cell pmid:23827671
Chen HF and Su HM Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. 2013 J. Nutr. Biochem. pmid:22818715
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
Kitson AP et al. Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23764042
Taha AY et al. A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. 2013 Epilepsy Behav pmid:23376336
Collins MA et al. Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. 2013 Neurotox Res pmid:23184649
Ramkumar HL et al. Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. 2013 J. Nutr. pmid:23677863
Nobre ME et al. Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. 2013 Nutr Res pmid:23684444
Xu ZZ et al. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. 2013 Ann. Neurol. pmid:23686636
Flock MR et al. Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. 2013 Diabetes Metab. Res. Rev. pmid:23592441
Nagachinta S and Akoh CC Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. 2013 J. Agric. Food Chem. pmid:23597247
Mortensen K and Tawia S Sustained breastfeeding. 2013 Breastfeed Rev pmid:23600325
Opperman M and Benade S Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. 2013 Cardiovasc J Afr pmid:24240381
Reinders I et al. Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. 2013 Eur J Clin Nutr pmid:24084512
Begum G et al. ER stress and effects of DHA as an ER stress inhibitor. 2013 Transl Stroke Res pmid:24323417
Bjorgvinsdottir L et al. Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? 2013 Cardiology pmid:23948862
Lee AL and Park Y The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. 2013 Ann. Nutr. Metab. pmid:23949659
Metherel AH et al. EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. 2013 Lipids pmid:23949919
Ishikado A et al. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. 2013 PLoS ONE pmid:23936010
Hoshi T et al. Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23940844
Sadli N et al. Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. 2013 Cell. Physiol. Biochem. pmid:23942088
Chung ML et al. Profiling of oxidized lipid products of marine fish under acute oxidative stress. 2013 Food Chem. Toxicol. pmid:23220612
van der Merwe LF et al. Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. 2013 Am. J. Clin. Nutr. pmid:23221579
Betancor MB et al. Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23202658
Crawford MA et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23206328
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Zeilmaker MJ et al. Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. 2013 Food Chem. Toxicol. pmid:22079313
Wu BT et al. Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. 2013 Br. J. Nutr. pmid:22691303
Marcon R et al. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. 2013 J. Immunol. pmid:24038091
Tam VC Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. 2013 Semin. Immunol. pmid:24084369
Fontes-Villalba M et al. African hominin stable isotopic data do not necessarily indicate grass consumption. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24062471
Yusof HM et al. Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. 2013 Mar Drugs pmid:24065166
Stanley WC et al. Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. 2013 J Cardiovasc Transl Res pmid:24065618
Jaudszus A et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. 2013 J. Lipid Res. pmid:23349208
Neuhofer A et al. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. 2013 Diabetes pmid:23349501
Sofi F et al. The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. 2013 Asia Pac J Clin Nutr pmid:23353608
McEwen BJ et al. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. 2013 Semin. Thromb. Hemost. pmid:23329646
Sun SN et al. Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. 2013 Int J Clin Exp Pathol pmid:23330014