DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee HJ et al. | Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. | 2013 | Int. J. Biochem. Cell Biol. | pmid:24120851 |
| Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
| Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
| Galvao TF et al. | Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23103493 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Yang YC et al. | Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. | 2013 | J. Nutr. Biochem. | pmid:22901690 |
| Tsuboi H et al. | Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. | 2013 | Clin Nutr | pmid:22901744 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
| Drover JR et al. | Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. | 2013 | Early Hum. Dev. | pmid:23411369 |
| Sundrani D et al. | Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. | 2013 | Reproduction | pmid:23412981 |
| Chien KL et al. | A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. | 2013 | BMC Med Res Methodol | pmid:23414574 |
| Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
| Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. | 2013 | Bioprocess Biosyst Eng | pmid:23053417 |
| Hjorth E et al. | Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. | 2013 | J. Alzheimers Dis. | pmid:23481688 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Kang JX and Gleason ED | Omega-3 Fatty acids and hippocampal neurogenesis in depression. | 2013 | CNS Neurol Disord Drug Targets | pmid:23574158 |
| Yamaguchi M et al. | Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. | 2013 | J Occup Health | pmid:23574777 |
| Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
| Berberovic E et al. | Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23480524 |
| Lee HN et al. | Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. | 2013 | J. Cell. Sci. | pmid:23788426 |
| Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
| Montes R et al. | Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. | 2013 | Eur J Clin Nutr | pmid:23549201 |
| Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
| Devaraj S et al. | Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. | 2013 | Atherosclerosis | pmid:23528830 |
| Finlin BS et al. | Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. | 2013 | J. Nutr. Biochem. | pmid:23528972 |
| Wu JH et al. | Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. | 2013 | J Am Heart Assoc | pmid:24145742 |
| Végran F et al. | Socs3 induction by PPARγ restrains cancer-promoting inflammation. | 2013 | Cell Cycle | pmid:23803735 |
| Bruno MJ et al. | Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. | 2013 | Faraday Discuss. | pmid:23805753 |
| Jung SB et al. | Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23806688 |
| Qu L et al. | Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. | 2013 | Bioprocess Biosyst Eng | pmid:23673897 |
| Schuchardt JP and Hahn A | Bioavailability of long-chain omega-3 fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23676322 |
| Kitson AP et al. | Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23764042 |
| Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
| Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
| Ostapchenko VG et al. | Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. | 2013 | J. Neurochem. | pmid:23651058 |
| Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
| Opperman M and Benade S | Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. | 2013 | Cardiovasc J Afr | pmid:24240381 |
| Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
| Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
| Rosa A et al. | Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. | 2013 | Food Chem. Toxicol. | pmid:23948356 |
| Fogagnolo Mauricio A et al. | Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. | 2013 | Clin Nutr | pmid:23218947 |
| Nobili V et al. | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23220074 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Zeilmaker MJ et al. | Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. | 2013 | Food Chem. Toxicol. | pmid:22079313 |
| Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
| Borghetti G et al. | Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. | 2013 | Braz. J. Med. Biol. Res. | pmid:24036940 |
| Denis I et al. | Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. | 2013 | Ageing Res. Rev. | pmid:23395782 |
| Yan Y et al. | Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. | 2013 | Bioresour. Technol. | pmid:23347925 |
| Jaudszus A et al. | Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. | 2013 | J. Lipid Res. | pmid:23349208 |