DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vyncke KE et al. | Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. | 2013 | Nutrition | pmid:23312763 |
| Yu Y et al. | DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. | 2013 | J. Nutr. Biochem. | pmid:23337348 |
| Xu J et al. | Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. | 2013 | FEBS J. | pmid:24128189 |
| Kimura R et al. | DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. | 2013 | J. Lipid Res. | pmid:24133194 |
| Méndez L et al. | Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. | 2013 | Free Radic. Biol. Med. | pmid:23159545 |
| Cooke M et al. | Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. | 2013 | Mol. Cell. Endocrinol. | pmid:23159987 |
| Al-Hilal M et al. | Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. | 2013 | J. Lipid Res. | pmid:23160180 |
| Walker CG et al. | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. | 2013 | Nutrition | pmid:23102888 |
| Kondo T et al. | Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. | 2013 | Cell Stem Cell | pmid:23434393 |
| GarcÃa-Layana A et al. | Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. | 2013 | Nutrients | pmid:23434908 |
| Williams JJ et al. | N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. | 2013 | PLoS ONE | pmid:23437099 |
| Mayer-Davis EJ et al. | Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. | 2013 | Diabetes Care | pmid:23801797 |
| Kaur G et al. | Orally administered [¹â´C]DPA and [¹â´C]DHA are metabolised differently to [¹â´C]EPA in rats. | 2013 | Br. J. Nutr. | pmid:22578196 |
| Dangour AD and Allen E | Do omega-3 fats boost brain function in adults? Are we any closer to an answer? | 2013 | Am. J. Clin. Nutr. | pmid:23535110 |
| Kitamura F et al. | Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. | 2013 | J Oleo Sci | pmid:23535307 |
| Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
| Fukui M et al. | EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. | 2013 | J. Cell. Biochem. | pmid:22903547 |
| Stark MJ et al. | Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. | 2013 | Reproduction | pmid:23813449 |
| Rupp TP et al. | Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. | 2013 | Cardiology | pmid:23816637 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Wu Z et al. | Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. | 2013 | Brain Res. Bull. | pmid:23817050 |
| Zhang G et al. | Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23553837 |
| Santos-Soto IJ et al. | Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. | 2013 | PLoS ONE | pmid:24349072 |
| Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
| Terrando N et al. | Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. | 2013 | FASEB J. | pmid:23709617 |
| Fietkau R et al. | A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. | 2013 | Cancer | pmid:23765693 |
| Jiang LH et al. | Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. | 2013 | Pharm Biol | pmid:23767459 |
| Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
| Kagan ML et al. | Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. | 2013 | Lipids Health Dis | pmid:23855409 |
| Lee HN and Surh YJ | Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. | 2013 | Biochem. Pharmacol. | pmid:23856291 |
| Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
| Eickmeier O et al. | Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. | 2013 | Mucosal Immunol | pmid:22785226 |
| Hamaoka N et al. | Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. | 2013 | J. Food Sci. | pmid:23915081 |
| Jing K et al. | Omega-3 polyunsaturated fatty acids and cancer. | 2013 | Anticancer Agents Med Chem | pmid:23919748 |
| Pagán A et al. | Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23921142 |
| Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
| Trofimiuk E and Braszko JJ | Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. | 2013 | Physiol. Behav. | pmid:23672853 |
| Harris WS et al. | Omega-3 fatty acids and cardiovascular disease: new developments and applications. | 2013 | Postgrad Med | pmid:24200766 |
| Ding N et al. | Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. | 2013 | J Oleo Sci | pmid:24200935 |
| Yee LD et al. | The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. | 2013 | Mol Nutr Food Res | pmid:23213007 |
| Kilpinen L et al. | Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. | 2013 | J. Lipid Res. | pmid:23271708 |
| Becerir C et al. | The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. | 2013 | J Enzyme Inhib Med Chem | pmid:22591320 |
| Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |
| Andrade-Vieira R et al. | Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. | 2013 | Cancer Biol. Ther. | pmid:24025358 |
| Leggieri E et al. | Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. | 2013 | Minerva Pediatr. | pmid:24051972 |
| Li D et al. | Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. | 2013 | Mucosal Immunol | pmid:23462912 |
| Zou Z et al. | Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. | 2013 | J. Lipid Res. | pmid:24052576 |
| Song X et al. | Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. | 2013 | J. Agric. Food Chem. | pmid:24053543 |
| Nobili V et al. | The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. | 2013 | J Med Food | pmid:24074360 |
| Uusitalo L et al. | Fatty acids in serum and diet--a canonical correlation analysis among toddlers. | 2013 | Matern Child Nutr | pmid:22066932 |