DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Keim SA et al. | Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. | 2012 | Matern Child Nutr | pmid:21615865 |
| Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
| Betancor MB et al. | Selenium inclusion decreases oxidative stress indicators and muscle injuries in sea bass larvae fed high-DHA microdiets. | 2012 | Br. J. Nutr. | pmid:22409905 |
| Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
| Sinn N et al. | Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. | 2012 | Br. J. Nutr. | pmid:21929835 |
| Shabrani NC et al. | Polyunsaturated fatty acids confer cryoresistance on megakaryocytes generated from cord blood and also enhance megakaryocyte production from cryopreserved cord blood cells. | 2012 | Cytotherapy | pmid:22250991 |
| Isobe Y et al. | Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. | 2012 | J. Biol. Chem. | pmid:22275352 |
| Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
| Mozaffarian D and Wu JH | (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? | 2012 | J. Nutr. | pmid:22279134 |
| Maki KC and Rains TM | Stearidonic acid raises red blood cell membrane eicosapentaenoic acid. | 2012 | J. Nutr. | pmid:22279138 |
| Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
| Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
| Molloy C et al. | Docosahexaenoic acid and visual functioning in preterm infants: a review. | 2012 | Neuropsychol Rev | pmid:23065239 |
| Kim YJ et al. | Plasma phospholipid fatty acid composition in ischemic stroke: importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. | 2012 | Atherosclerosis | pmid:23044095 |
| Tanaka T et al. | Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. | 2012 | Lipids | pmid:22411689 |
| Bragt MC and Mensink RP | Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21429719 |
| D'Eliseo D et al. | Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression. | 2012 | J. Nutr. Biochem. | pmid:21684140 |
| Ruan D and So SP | Screening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells. | 2012 | BMC Complement Altern Med | pmid:22938033 |
| Lin PY et al. | A meta-analytic review of polyunsaturated fatty acid compositions in dementia. | 2012 | J Clin Psychiatry | pmid:22938939 |
| Shi T et al. | Identification of a novel C22-∆4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. | 2012 | Biotechnol. Lett. | pmid:22941368 |
| Finlin BS et al. | DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. | 2012 | J. Nutr. Biochem. | pmid:21852085 |
| Cortie CH and Else PL | Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. | 2012 | Int J Mol Sci | pmid:23203135 |
| Dong PS et al. | [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. | 2012 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:22883096 |
| Kuang YL et al. | Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. | 2012 | Br. J. Nutr. | pmid:22221450 |
| Whyte C et al. | N-3 long-chain polyunsaturated fatty acids inhibit smooth muscle cell migration by modulating urokinase plasminogen activator receptor through MEK/ERK-dependent and -independent mechanisms. | 2012 | J. Nutr. Biochem. | pmid:22221673 |
| de Velasco PC et al. | Nutritional restriction of omega-3 fatty acids alters topographical fine tuning and leads to a delay in the critical period in the rodent visual system. | 2012 | Exp. Neurol. | pmid:22227060 |
| de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
| Castro-González MI et al. | [Evaluation of ten fish species to be included as part of renal diet, due to their protein, phosphorus and fatty acids content]. | 2012 | Arch Latinoam Nutr | pmid:23610899 |
| Motter AL and Ahern GP | TRPA1 is a polyunsaturated fatty acid sensor in mammals. | 2012 | PLoS ONE | pmid:22723860 |
| Ma Y et al. | DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity. | 2012 | Expert Opin Drug Discov | pmid:22724444 |
| Harris WS et al. | Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. | 2012 | Atherosclerosis | pmid:22727409 |
| Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
| Nakano M et al. | CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. | 2012 | Mol. Pharmacol. | pmid:22772592 |
| Mraz J et al. | Culture of common carp (Cyprinus carpio) with defined flesh quality for prevention of cardiovascular diseases using finishing feeding strategy. | 2012 | Neuro Endocrinol. Lett. | pmid:23183512 |
| Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Cunningham E | Are krill oil supplements a better source of n-3 fatty acids than fish oil supplements? | 2012 | J Acad Nutr Diet | pmid:22459227 |
| Rognlien M et al. | Consumer perception and sensory effect of oxidation in savory-flavored yogurt enriched with n-3 lipids. | 2012 | J. Dairy Sci. | pmid:22459817 |
| Pottala JV et al. | Red blood cell fatty acids are associated with depression in a case-control study of adolescents. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22464051 |
| Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Sahin N et al. | A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. | 2012 | Nutr Neurosci | pmid:23232054 |
| Hughes BH et al. | Fish oil fortification of soft goat cheese. | 2012 | J. Food Sci. | pmid:22309698 |
| Milte CM et al. | Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. | 2012 | Nutrition | pmid:22541055 |
| Dhobale M et al. | Association of brain-derived neurotrophic factor and tyrosine kinase B receptor in pregnancy. | 2012 | Neuroscience | pmid:22542551 |
| Sierra S et al. | Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish. | 2012 | Brain Res. Bull. | pmid:22542883 |
| Tang X et al. | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. | 2012 | Lipids Health Dis | pmid:22676394 |
| Bazan NG et al. | Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. | 2012 | Exp. Neurol. | pmid:22542947 |
| Imam MH and Lindor KD | Primary sclerosing cholangitis: providing a safe and effective treatment. | 2012 | Expert Rev Gastroenterol Hepatol | pmid:22646247 |
| Galicia-Connolly E et al. | Complementary, holistic, and integrative medicine: therapies for neurodevelopment in preterm infants. | 2012 | Pediatr Rev | pmid:22659260 |