Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Croasdell A et al. | Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. | 2016 | J. Immunol. | pmid:26843331 |
Abdulnour RE et al. | Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. | 2016 | Mucosal Immunol | pmid:26647716 |
López-Luna P et al. | Fate of orally administered radioactive fatty acids in the late-pregnant rat. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26714850 |
Wang ZQ et al. | Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. | 2016 | J. Cardiovasc. Pharmacol. | pmid:26657886 |
Viola JR et al. | Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. | 2016 | Circ. Res. | pmid:27531933 |
Georgieva R et al. | Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. | 2016 | Langmuir | pmid:26794691 |
Inoue Y et al. | Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. | 2016 | Crit. Care Med. | pmid:26509319 |
Nagai T et al. | Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. | 2016 | PLoS ONE | pmid:27824904 |
Lu Y et al. | Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. | 2016 | Biosens Bioelectron | pmid:26710343 |
Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
Suzuki-Kemuriyama N et al. | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2016 | PLoS ONE | pmid:27333187 |
Kim SM et al. | Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. | 2016 | EBioMedicine | pmid:27322464 |
Gold DR et al. | Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. | 2016 | Contemp Clin Trials | pmid:26784651 |
Fialkow J | Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. | 2016 | Am J Cardiovasc Drugs | pmid:27138439 |
Wong BH et al. | Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. | 2016 | J. Biol. Chem. | pmid:27008858 |
Gao J et al. | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. | 2016 | Int. J. Dev. Neurosci. | pmid:26639559 |
Pinçon A et al. | Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. | 2016 | J. Nutr. Biochem. | pmid:27239755 |
Dagorn F et al. | Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. | 2016 | Mar Drugs | pmid:27231919 |
Seeger DR and Murphy EJ | Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. | 2016 | Lipids | pmid:26797754 |
Tran DQ et al. | Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. | 2016 | Mol. Cell. Endocrinol. | pmid:26923440 |
Bernhard W et al. | Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. | 2016 | Eur J Nutr | pmid:26363610 |
Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
Heskey CE et al. | Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. | 2016 | Am. J. Clin. Nutr. | pmid:26912497 |
Mason RP et al. | Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. | 2016 | Biochim. Biophys. Acta | pmid:27718370 |
Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
Revuelta M et al. | Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. | 2016 | Brain Pathol. | pmid:25990815 |
Kuda O et al. | Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. | 2016 | Diabetes | pmid:27313314 |
Kim KH et al. | Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. | 2016 | Int J Chron Obstruct Pulmon Dis | pmid:27313451 |
Barden A et al. | n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. | 2016 | Nutrients | pmid:27007392 |
Gharekhani A et al. | Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. | 2016 | Iran J Kidney Dis | pmid:27721230 |
Zhao Q et al. | Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung. | 2016 | J Transl Med | pmid:27009328 |
Midtbø LK et al. | Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. | 2015 | J. Nutr. Biochem. | pmid:25776459 |
Croasdell A et al. | Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26301452 |
Qin Y et al. | Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | 2015 | PLoS ONE | pmid:26226139 |
Orr SK et al. | Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25770181 |
Rossi S et al. | Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages. | 2015 | Mediators Inflamm. | pmid:25684860 |
Lastrucci C et al. | Molecular and cellular profiles of the resolution phase in a damage-associated molecular pattern (DAMP)-mediated peritonitis model and revelation of leukocyte persistence in peritoneal tissues. | 2015 | FASEB J. | pmid:25609430 |
Akagi D et al. | Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. | 2015 | FASEB J. | pmid:25777995 |
Dorninger F et al. | Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. | 2015 | Biochim. Biophys. Acta | pmid:25463479 |
Barden AE et al. | Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirin. | 2015 | Am. J. Clin. Nutr. | pmid:26561623 |
Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
Filipcikova R et al. | Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23446211 |
Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
Linhartova P and Sampels S | Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. | 2015 | Lipids Health Dis | pmid:26627047 |
Park HG et al. | The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. | 2015 | FASEB J. | pmid:26065859 |
Lim JY et al. | Biological Roles of Resolvins and Related Substances in the Resolution of Pain. | 2015 | Biomed Res Int | pmid:26339646 |
Schwager J et al. | ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. | 2015 | Biomed Res Int | pmid:26301248 |
Katakura M et al. | Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. | 2015 | PLoS ONE | pmid:26485038 |
Cotogni P et al. | The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients. | 2015 | Biomed Res Int | pmid:26301250 |
Kawakami Y et al. | Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. | 2015 | Nutr J | pmid:25896182 |