DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mori TA | Dietary n-3 PUFA and CVD: a review of the evidence. | 2014 | Proc Nutr Soc | pmid:24119287 |
| Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
| Burns-Whitmore B et al. | Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. | 2014 | Nutr J | pmid:24673793 |
| Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
| Makrides M et al. | Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation. | 2014 | JAMA | pmid:24794375 |
| Mirakaj V et al. | Vagus nerve controls resolution and pro-resolving mediators of inflammation. | 2014 | J. Exp. Med. | pmid:24863066 |
| Chen R et al. | [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. | 2014 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24796591 |
| Ramon S et al. | The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? | 2014 | J. Immunol. | pmid:25392529 |
| Velten M et al. | Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. | 2014 | J. Nutr. | pmid:24453131 |
| Mereghetti P et al. | A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid. | 2014 | Biochim. Biophys. Acta | pmid:25018005 |
| Lager S et al. | Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25143349 |
| Sato K et al. | Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619. | 2014 | Biol. Pharm. Bull. | pmid:24369179 |
| Nishinaka T et al. | Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. | 2014 | J. Pharmacol. Sci. | pmid:24758921 |
| Nagao K et al. | Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells. | 2014 | J Oleo Sci | pmid:25213447 |
| Nanjappa D et al. | Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. | 2014 | Mar Drugs | pmid:24445306 |
| Begum G et al. | Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. | 2014 | J. Neurosci. | pmid:24599472 |
| Levy BD and Serhan CN | Resolution of acute inflammation in the lung. | 2014 | Annu. Rev. Physiol. | pmid:24313723 |
| Sertoglu E et al. | Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. | 2014 | Chem. Phys. Lipids | pmid:24384240 |
| Stoffel W et al. | Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. | 2014 | EMBO Rep. | pmid:24378641 |
| Jiang M et al. | Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. | 2014 | Mar Drugs | pmid:24608969 |
| Hixson SM et al. | Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. | 2014 | Lipids | pmid:24264359 |
| Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
| Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
| Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
| Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
| Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
| Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
| Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
| Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
| Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
| Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
| Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
| Yu Y et al. | DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. | 2013 | J. Nutr. Biochem. | pmid:23337348 |
| Larson MK et al. | Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23174566 |
| Klingler M et al. | Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. | 2013 | Br. J. Nutr. | pmid:22874641 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. | 2013 | Bioprocess Biosyst Eng | pmid:23053417 |
| Kamolrat T and Gray SR | The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23438435 |
| Kang JX and Gleason ED | Omega-3 Fatty acids and hippocampal neurogenesis in depression. | 2013 | CNS Neurol Disord Drug Targets | pmid:23574158 |
| Montes R et al. | Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. | 2013 | Eur J Clin Nutr | pmid:23549201 |
| Berman DR et al. | Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. | 2013 | Neonatology | pmid:23817197 |
| Devaraj S et al. | Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. | 2013 | Atherosclerosis | pmid:23528830 |
| Xie W et al. | Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. | 2013 | Lab. Invest. | pmid:23857007 |
| Titova OE et al. | Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. | 2013 | Age (Dordr) | pmid:22791395 |
| Schuchardt JP and Hahn A | Bioavailability of long-chain omega-3 fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23676322 |
| Cheng R et al. | Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. | 2013 | World J. Microbiol. Biotechnol. | pmid:23292648 |
| Opperman M and Benade S | Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. | 2013 | Cardiovasc J Afr | pmid:24240381 |
| Rosa A et al. | Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. | 2013 | Food Chem. Toxicol. | pmid:23948356 |
| Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
| Atwell K et al. | Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. | 2013 | J Paediatr Child Health | pmid:23279074 |