DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hypotension D007022 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Heart Failure D006333 36 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Burns D002056 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Cataract D002386 34 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Stroke D020521 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Proteinuria D011507 30 associated lipids
Obesity D009765 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Neuralgia D009437 28 associated lipids
Angina Pectoris D000787 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Hypoxia D000860 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Agren JJ et al. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430389
Chen ZY and Istfan NW Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161587
Daak AA et al. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24095588
Ott J et al. Lipids in critical care medicine. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21546231
Kuipers RS et al. High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763440
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Yoshino S and Ellis EF Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550967
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
Burdge GC Metabolism of alpha-linolenic acid in humans. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16828546
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Chen CT et al. Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19237271
Brenna JT and Salem N Workshop proceedings: DHA as a required nutrient. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19604681
Maki KC et al. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21775113
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Sala-Vila A et al. Influence of dietary source of docosahexaenoic and arachidonic acids on their incorporation into membrane phospholipids of red blood cells in term infants. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16326086
Erdogan H et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253883
Mathieu G et al. Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18579362
Qin X et al. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802938
Green P et al. Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19342208
Wiest MM et al. Plasma fatty acid profiles in autism: a case-control study. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19307110
Antalis CJ et al. Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19217763
Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Horrobin D et al. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711245
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Mueller MJ Isoprostane nomenclature: inherent problems may cause setbacks for the development of the isoprostanoid field. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20034775
Little SJ et al. Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17928211
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
Coetzee M et al. Effects of arachidonic acid, docosahexaenoic acid and prostaglandin E(2) on cell proliferation and morphology of MG-63 and MC3T3-E1 osteoblast-like cells. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17113274
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Murali G et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24332315
Pottala JV et al. Red blood cell fatty acids are associated with depression in a case-control study of adolescents. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464051
Raza Shaikh S and Brown DA Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464052
Engler MM et al. The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10670690
Kim HW et al. Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880477
Gawrisch K et al. Insights from biophysical studies on the role of polyunsaturated fatty acids for function of G-protein coupled membrane receptors. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:19004627
Marcheselli VL et al. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:19931440
Serhan CN Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:19008087
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Leaf A Omega-3 fatty acids and prevention of ventricular fibrillation. 1995 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:7784457
van Goor SA et al. Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20022733
Gregor JI et al. Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16226437
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
Brown AJ et al. Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1836062
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
Frøyland L et al. Hypotriacylglycerolemic component of fish oil. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430383