DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hypotension D007022 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Heart Failure D006333 36 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Burns D002056 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Cataract D002386 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Memory Disorders D008569 33 associated lipids
Hypothyroidism D007037 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Proteinuria D011507 30 associated lipids
Kidney Diseases D007674 29 associated lipids
Obesity D009765 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Neuralgia D009437 28 associated lipids
Angina Pectoris D000787 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Cholestasis D002779 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Daak AA et al. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24095588
Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
Sayanova O and Napier JA Transgenic oilseed crops as an alternative to fish oils. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21596549
Suzuki R et al. Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12054914
Kruger MC and Schollum LM Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16154334
Chapkin RS et al. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19502020
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
McNamara RK The emerging role of omega-3 fatty acids in psychiatry. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930969
Urquhart P et al. Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487303
Shinto L et al. Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19171471
Freeman MP Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930971
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Gousset-Dupont A et al. The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17229561
Jensen CL and Lapillonne A Docosahexaenoic acid and lactation. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19632101
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Pakala R et al. Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397410
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
Calderon F and Kim HY Role of RXR in neurite outgrowth induced by docosahexaenoic acid. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036800
Rousseau-Ralliard D et al. Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19428232
Michael-Titus AT Omega-3 fatty acids and neurological injury. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036801
Kim W et al. n-3 polyunsaturated fatty acids--physiological relevance of dose. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20188532
Astarita G and Piomelli D Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21543199
Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Qiu X Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538082
Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
de Groot RH et al. Exploratory study into the relation between plasma phospholipid fatty acid status and cognitive performance. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17317131
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Rahman T et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106645
Horrobin D et al. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711245
Block RC et al. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106646
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Honda KL et al. Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25921297
Smit EN et al. Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913225
Mukhopadhyay S et al. Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of guinea pig alveolar apical membranes. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913226
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Hoffmire CA et al. Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22472486
Risé P and Galli C Arachidonic and docosahexaenoic acids differentially affect the expression of fatty acyl-CoA oxidase, protein kinase C and lipid peroxidation in HepG2 cells. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471123
Kuipers RS et al. Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425684
Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
Magnusardottir AR et al. Docosahexaenoic acid in red blood cells of women of reproductive age is positively associated with oral contraceptive use and physical activity. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19071003
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Crawford MA et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23206328
Lokesh BR and Kinsella JE Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846090
Makrides M DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22698951
van Goor SA et al. Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20022733
Gregor JI et al. Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16226437
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780
Polozova A et al. Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16837179