Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gelsomino G et al. | Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. | 2013 | Mol. Cancer | pmid:24225025 |
Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. | 2013 | Adv Nutr | pmid:24228198 |
Lotrich FE et al. | Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. | 2013 | J Psychosom Res | pmid:24182638 |
Pande G et al. | Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. | 2013 | J. Agric. Food Chem. | pmid:24117100 |
Murphy EJ | A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. | 2013 | J. Neurochem. | pmid:24117623 |
Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
Carlson SJ et al. | The role of the ω-3 fatty acid DHA in the human life cycle. | 2013 | JPEN J Parenter Enteral Nutr | pmid:23192455 |
Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
Lee LK et al. | The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. | 2013 | J. Nutr. Biochem. | pmid:22898566 |
Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
Gao M et al. | Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. | 2013 | J Oleo Sci | pmid:23470441 |
Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
Kimura AK and Kim HY | Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. | 2013 | J. Lipid Res. | pmid:23071296 |
Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
Miller E et al. | A short-term n-3 DPA supplementation study in humans. | 2013 | Eur J Nutr | pmid:22729967 |
Friedman AN et al. | Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. | 2013 | Am. J. Nephrol. | pmid:23816975 |
Zulyniak MA et al. | Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. | 2013 | Metab. Clin. Exp. | pmid:23522836 |
Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
Gódor-Kacsándi A et al. | Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. | 2013 | Acta Physiol Hung | pmid:23524180 |
Yao C et al. | Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. | 2013 | Mol Med Rep | pmid:23799606 |
Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
Al-Farsi YM et al. | Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. | 2013 | Nutrition | pmid:23800562 |
Samieri C et al. | Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. | 2013 | J. Lipid Res. | pmid:23801662 |
Leino O et al. | Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. | 2013 | Food Chem. Toxicol. | pmid:21723361 |
Mizia-Stec K et al. | N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. | 2013 | Cardiol J | pmid:24469870 |
Merendino N et al. | Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. | 2013 | Biomed Res Int | pmid:23762838 |
Hunina LM et al. | [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. | 2013 | Fiziol Zh | pmid:23713352 |
Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
Veszelka S et al. | Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. | 2013 | J. Alzheimers Dis. | pmid:23645098 |
Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
Ramprasath VR et al. | Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. | 2013 | Lipids Health Dis | pmid:24304605 |
Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
Dabkowski ER et al. | Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. | 2013 | Cardiovasc Drugs Ther | pmid:24013804 |
Porta A et al. | Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. | 2013 | Chem. Phys. Lipids | pmid:23895793 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
Takkunen M et al. | Dietary fat in relation to erythrocyte fatty acid composition in men. | 2013 | Lipids | pmid:23975575 |
Qu L et al. | Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. | 2013 | Appl. Biochem. Biotechnol. | pmid:24061873 |
Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |
Siddiqui RA et al. | Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. | 2013 | BMC Cancer | pmid:24034496 |
Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |