Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wright TC et al. | Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. | 2003 | J. Dairy Sci. | pmid:12703623 |
Mansour MP et al. | The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. | 2003 | Phytochemistry | pmid:12711135 |
Horrobin D et al. | The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711245 |
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. | 2003 | Harv Heart Lett | pmid:12711572 | |
Insua MF et al. | Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714666 |
Rotstein NP et al. | Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714668 |
James MJ et al. | Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12716664 |
Kew S et al. | Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. | 2003 | Am. J. Clin. Nutr. | pmid:12716684 |
Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
Marangell LB et al. | A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. | 2003 | Am J Psychiatry | pmid:12727707 |
Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
Berry CB and McBean GJ | An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. | 2003 | Brain Res. | pmid:12729959 |
Thorpe M | Infant formula supplemented with DHA: are there benefits? | 2003 | J Am Diet Assoc | pmid:12733531 |
Sumino H et al. | Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. | 2003 | Endocr. J. | pmid:12733709 |
Cha MC et al. | Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. | 2002 | Nutr Cancer | pmid:12734065 |
Sarkadi-Nagy E et al. | The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. | 2003 | Pediatr. Res. | pmid:12736388 |
Gu X et al. | Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. | 2003 | J. Org. Chem. | pmid:12737551 |
Merritt RJ et al. | Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. | 2003 | Food Chem. Toxicol. | pmid:12738195 |
Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
Almansa E et al. | Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12743726 |
Armstrong VT et al. | Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. | 2003 | Arch. Biochem. Biophys. | pmid:12745257 |
Llorente AM et al. | Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. | 2003 | Am. J. Obstet. Gynecol. | pmid:12748510 |
Sano Y et al. | A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. | 2003 | J. Biol. Chem. | pmid:12754259 |
Yusufi AN et al. | Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. | 2003 | J. Lab. Clin. Med. | pmid:12761475 |
de Swaaf ME et al. | Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. | 2003 | J. Biotechnol. | pmid:12770501 |
Harel M and Place AR | Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12781976 |
Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
Torres CF et al. | Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. | 2003 | Biotechnol. Bioeng. | pmid:12783483 |
Eldho NV et al. | Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. | 2003 | J. Am. Chem. Soc. | pmid:12785780 |
Youssef JA et al. | Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. | 2003 | Free Radic. Biol. Med. | pmid:12788483 |
Del Castillo IC et al. | Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. | 2003 | J. Surg. Res. | pmid:12788663 |
Rodriguez A et al. | Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | 2003 | Eur J Clin Nutr | pmid:12792656 |
pmid:12794672 | ||||
Clements KM et al. | Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. | 2003 | Dev Psychobiol | pmid:12794779 |
Hulbert AJ | Life, death and membrane bilayers. | 2003 | J. Exp. Biol. | pmid:12796449 |
Ng R | Fish oil therapy in recurrent IgA nephropathy. | 2003 | Ann. Intern. Med. | pmid:12809474 |
Wang Z | Role of redox state in modulation of ion channel function by fatty acids and phospholipids. | 2003 | Br. J. Pharmacol. | pmid:12812990 |
Judé S et al. | Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. | 2003 | Br. J. Pharmacol. | pmid:12813005 |
Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
Chen H et al. | EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818567 |
Rojas CV et al. | Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12824268 |
Qian SY et al. | Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12826254 |
Speake BK et al. | Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12827419 |
Högyes E et al. | Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. | 2003 | Neuroscience | pmid:12831859 |
Hoffman DR et al. | Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. | 2003 | J. Pediatr. | pmid:12838196 |
Strokin M et al. | Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. | 2003 | Br. J. Pharmacol. | pmid:12839876 |
Montgomery C et al. | Maternal docosahexaenoic acid supplementation and fetal accretion. | 2003 | Br. J. Nutr. | pmid:12844385 |