DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypotension D007022 41 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Heart Failure D006333 36 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Burns D002056 34 associated lipids
Cataract D002386 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Hypothyroidism D007037 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Proteinuria D011507 30 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Obesity D009765 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Neuralgia D009437 28 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Hypoxia D000860 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Wright TC et al. Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. 2003 J. Dairy Sci. pmid:12703623
Mansour MP et al. The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. 2003 Phytochemistry pmid:12711135
Horrobin D et al. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711245
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. 2003 Harv Heart Lett pmid:12711572
Insua MF et al. Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714666
Rotstein NP et al. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714668
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
Kew S et al. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. 2003 Am. J. Clin. Nutr. pmid:12716684
Wallace FA et al. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. 2003 Br. J. Nutr. pmid:12720588
Mattos R et al. Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. 2003 Biol. Reprod. pmid:12724278
Li H et al. [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. 2000 Wei Sheng Yan Jiu pmid:12725043
Marangell LB et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. 2003 Am J Psychiatry pmid:12727707
Inagaki K et al. Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. 2003 Biosci. Biotechnol. Biochem. pmid:12729021
Berry CB and McBean GJ An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. 2003 Brain Res. pmid:12729959
Thorpe M Infant formula supplemented with DHA: are there benefits? 2003 J Am Diet Assoc pmid:12733531
Sumino H et al. Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. 2003 Endocr. J. pmid:12733709
Cha MC et al. Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. 2002 Nutr Cancer pmid:12734065
Sarkadi-Nagy E et al. The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. 2003 Pediatr. Res. pmid:12736388
Gu X et al. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. 2003 J. Org. Chem. pmid:12737551
Merritt RJ et al. Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. 2003 Food Chem. Toxicol. pmid:12738195
Mashek DG and Grummer RR Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. 2003 J. Dairy Sci. pmid:12741546
Almansa E et al. Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12743726
Armstrong VT et al. Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. 2003 Arch. Biochem. Biophys. pmid:12745257
Llorente AM et al. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. 2003 Am. J. Obstet. Gynecol. pmid:12748510
Sano Y et al. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. 2003 J. Biol. Chem. pmid:12754259
Yusufi AN et al. Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. 2003 J. Lab. Clin. Med. pmid:12761475
de Swaaf ME et al. Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. 2003 J. Biotechnol. pmid:12770501
Harel M and Place AR Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781976
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Beck S et al. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. 2003 J. Biol. Chem. pmid:12782627
Torres CF et al. Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. 2003 Biotechnol. Bioeng. pmid:12783483
Eldho NV et al. Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. 2003 J. Am. Chem. Soc. pmid:12785780
Youssef JA et al. Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. 2003 Free Radic. Biol. Med. pmid:12788483
Del Castillo IC et al. Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. 2003 J. Surg. Res. pmid:12788663
Rodriguez A et al. Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. 2003 Eur J Clin Nutr pmid:12792656
pmid:12794672
Clements KM et al. Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. 2003 Dev Psychobiol pmid:12794779
Hulbert AJ Life, death and membrane bilayers. 2003 J. Exp. Biol. pmid:12796449
Ng R Fish oil therapy in recurrent IgA nephropathy. 2003 Ann. Intern. Med. pmid:12809474
Wang Z Role of redox state in modulation of ion channel function by fatty acids and phospholipids. 2003 Br. J. Pharmacol. pmid:12812990
Judé S et al. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. 2003 Br. J. Pharmacol. pmid:12813005
Erkkilä AT et al. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. 2003 Am. J. Clin. Nutr. pmid:12816772
Chen H et al. EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. 2003 J. Mol. Cell. Cardiol. pmid:12818567
Rojas CV et al. Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12824268
Qian SY et al. Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. 2003 Free Radic. Biol. Med. pmid:12826254
Speake BK et al. Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12827419
Högyes E et al. Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. 2003 Neuroscience pmid:12831859
Hoffman DR et al. Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. 2003 J. Pediatr. pmid:12838196
Strokin M et al. Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. 2003 Br. J. Pharmacol. pmid:12839876
Montgomery C et al. Maternal docosahexaenoic acid supplementation and fetal accretion. 2003 Br. J. Nutr. pmid:12844385