Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mustafa M et al. | Resolvin D1 protects periodontal ligament. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23864609 |
Gelsomino G et al. | Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. | 2013 | Mol. Cancer | pmid:24225025 |
Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. | 2013 | Adv Nutr | pmid:24228198 |
Amminger GP et al. | Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. | 2013 | Can J Psychiatry | pmid:23870722 |
Ishida T et al. | Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375839 |
Milic I et al. | Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. | 2013 | Anal. Chem. | pmid:23186270 |
Mizwicki MT et al. | 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. | 2013 | J. Alzheimers Dis. | pmid:23186989 |
Carlson SJ et al. | The role of the ω-3 fatty acid DHA in the human life cycle. | 2013 | JPEN J Parenter Enteral Nutr | pmid:23192455 |
Bazan NG et al. | Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107502 |
Fiol-deRoque MA et al. | Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. | 2013 | Biogerontology | pmid:24114505 |
Olson MV et al. | Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. | 2013 | Inflamm. Res. | pmid:24008816 |
Rovito D et al. | Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23168911 |
Sato SB et al. | Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. | 2013 | Biochim. Biophys. Acta | pmid:23085420 |
Marze S et al. | In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. | 2013 | Food Funct | pmid:23086175 |
Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
Liu J et al. | Screening and characterization of Isochrysis strains and optimization of culture conditions for docosahexaenoic acid production. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23423326 |
Metherel AH et al. | Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. | 2013 | Lipids Health Dis | pmid:23425563 |
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. | 2013 | Med Lett Drugs Ther | pmid:23836343 | |
Carlson SE et al. | DHA supplementation and pregnancy outcomes. | 2013 | Am. J. Clin. Nutr. | pmid:23426033 |
Cartiff SE et al. | Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. | 2013 | J. Anim. Sci. | pmid:23463554 |
Kataoka Y et al. | Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. | 2013 | Future Cardiol | pmid:23463969 |
McNamara RK | Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521863 |
Raatz SK et al. | Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. | 2013 | J Acad Nutr Diet | pmid:23351633 |
Goustard-Langelier B et al. | Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. | 2013 | J. Nutr. Biochem. | pmid:23036607 |
Usami M et al. | Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. | 2013 | Clin Nutr | pmid:23068014 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Lu Y et al. | Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. | 2013 | Neuroscience | pmid:23500096 |
Mozaffari-Khosravi H et al. | Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. | 2013 | Eur Neuropsychopharmacol | pmid:22910528 |
Cardenia V et al. | Health-related lipids components of sardine muscle as affected by photooxidation. | 2013 | Food Chem. Toxicol. | pmid:23500769 |
Dalli J et al. | The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. | 2013 | FASEB J. | pmid:23504711 |
Arem H et al. | Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. | 2013 | Eur J Nutr | pmid:22915050 |
Mickleborough TD | Omega-3 polyunsaturated fatty acids in physical performance optimization. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23400626 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
Saha SS and Ghosh M | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. | 2013 | Nutrition | pmid:23422533 |
Rahman MM et al. | DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. | 2013 | Breast Cancer Res. Treat. | pmid:24062211 |
Wijendran V et al. | Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24075244 |
Liu X et al. | Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. | 2013 | Anal. Biochem. | pmid:23850559 |
Khaled M et al. | Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. | 2013 | J. Periodontol. | pmid:23398023 |
Jans JJ et al. | Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. | 2013 | Mol. Genet. Metab. | pmid:23562298 |
Faxén-Irving G et al. | Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. | 2013 | J. Alzheimers Dis. | pmid:23563245 |
Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
Arnold C et al. | Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. | 2013 | JAMA Ophthalmol | pmid:23519529 |
Xu MX et al. | Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. | 2013 | CNS Neurosci Ther | pmid:23521911 |
Guo B et al. | Identification and heterologous expression of a Δ4-fatty acid desaturase gene from Isochrysis sphaerica. | 2013 | J. Microbiol. Biotechnol. | pmid:23851273 |
Zulyniak MA et al. | Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. | 2013 | Metab. Clin. Exp. | pmid:23522836 |
Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
Singh A et al. | Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. | 2013 | PLoS ONE | pmid:23844124 |
Muldoon MF et al. | Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. | 2013 | J. Nutr. | pmid:23884386 |
Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
Aslan M et al. | LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. | 2013 | Lipids Health Dis | pmid:24195588 |
Leino O et al. | Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. | 2013 | Food Chem. Toxicol. | pmid:21723361 |
Zawadzki M et al. | Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. | 2013 | Mar Drugs | pmid:23739042 |
Morel PC et al. | Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. | 2013 | Meat Sci. | pmid:23739265 |
Liu Y et al. | Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:23739309 |
Parletta N et al. | Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23756346 |
Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
Laird BD et al. | Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids. | 2013 | J. Nutr. | pmid:23616502 |
Sala-Vila A et al. | Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. | 2013 | J. Nutr. Biochem. | pmid:23618530 |
Shida T et al. | Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. | 2013 | Int J Pharm | pmid:23618969 |
Berger H et al. | SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. | 2013 | Cancer Res. | pmid:23619236 |
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. | 2013 | JAMA | pmid:23644932 | |
Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
Veszelka S et al. | Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. | 2013 | J. Alzheimers Dis. | pmid:23645098 |
Johnston DT et al. | Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. | 2013 | Nutr Neurosci | pmid:22748167 |
Ravacci GR et al. | Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. | 2013 | J. Nutr. Biochem. | pmid:22749134 |
Adler EM | Of fish oil, rafts, and scrambling things up. | 2013 | J. Gen. Physiol. | pmid:24277599 |
Hashimoto M et al. | Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2013 | Neurochem. Res. | pmid:23963508 |
Tabbaa M et al. | Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. | 2013 | Nutrients | pmid:23966110 |
Szklenar M et al. | Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. | 2013 | J. Vasc. Res. | pmid:23969947 |
Dabkowski ER et al. | Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. | 2013 | Cardiovasc Drugs Ther | pmid:24013804 |
Santos VC et al. | Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23239683 |
O'Sullivan BP et al. | Evolution of pancreatic function during the first year in infants with cystic fibrosis. | 2013 | J. Pediatr. | pmid:23245194 |
Rincón Cervera Mà et al. | Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. | 2013 | J. Biosci. Bioeng. | pmid:23287502 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
Köhnke T et al. | Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. | 2013 | Biomed Res Int | pmid:24083240 |
LluÃs L et al. | Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. | 2013 | Lipids Health Dis | pmid:24083393 |
Nikolakopoulou Z et al. | Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. | 2013 | Carcinogenesis | pmid:23892603 |
Takkunen M et al. | Dietary fat in relation to erythrocyte fatty acid composition in men. | 2013 | Lipids | pmid:23975575 |
Qu L et al. | Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. | 2013 | Appl. Biochem. Biotechnol. | pmid:24061873 |
D'Souza V et al. | Counteracting oxidative stress in pregnancy through modulation of maternal micronutrients and omega-3 fatty acids. | 2013 | Curr. Med. Chem. | pmid:24274816 |
Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |
Fenton JI and McCaskey SJ | Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266210 |
Rogers LK et al. | DHA supplementation: current implications in pregnancy and childhood. | 2013 | Pharmacol. Res. | pmid:23266567 |
Otsuka R et al. | Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. | 2013 | Lipids | pmid:23389403 |
Barbadoro P et al. | Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. | 2013 | Mol Nutr Food Res | pmid:23390041 |
Phang M et al. | Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. | 2013 | J. Nutr. | pmid:23390192 |
Cunnane SC et al. | Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22575581 |
Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
Thom VT et al. | Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. | 2013 | Cell. Physiol. Biochem. | pmid:23988425 |
Gupta A et al. | Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23990167 |
Satkunendrarajah K and Fehlings MG | Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. | 2013 | Exp. Neurol. | pmid:23994716 |
Li Y et al. | Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. | 2013 | Immunity | pmid:24238341 |